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• W2133871036 abstract "To effectively obtain tumour-specific markers, fractionated proteins obtained using reversed-phase high-performance liquid chromatography for patient-matched pre- and postoperative sera from bladder cancer patients were compared by two-dimensional gel electrophoresis. The usefulness of the identified proteins was confirmed immunohistochemically. S100A8 and S100A9 were identified as tumour-associated proteins. The increased immunoreactive expression of S100A8 protein was associated with bladder wall muscle invasion of the tumour and cancer-specific survival (p<0.05), and the increased immunoreactive expression of S100A9 protein was associated with the tumour grade (p<0.05). In addition, increased expressions of both proteins was associated with recurrence-free survival at a median follow-up of 32.9 months (both p<0.05). On multivariate analysis, the expression of S100A8 was a significant predictor of recurrence (p<0.05). These findings may help to identify biologically aggressive tumors and, thus, patients who might benefit from more intensive adjuvant therapy." @default.
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• W2133871036 date "2010-07-27" @default.
• W2133871036 modified "2023-10-02" @default.
• W2133871036 title "Proteomic study of sera from patients with bladder cancer: usefulness of S100A8 and S100A9 proteins." @default.
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• W2133871036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20656984" @default.
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