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• W2133885246 abstract "The respiratory chain or oxidative phosphorylation system (OxPhos) generates most of the chemical energy (ATP) used by our cells. The cytochrome c oxidase (CcO) is one of three protein complexes of OxPhos building up a proton gradient across the inner mitochondrial membrane, which is ultimately used by the ATP synthase to produce ATP. We present molecular dynamic simulations of CcO in a mimic of the mitochondrial membrane and identify precise binding sites of cardiolipin (CL, signature phospholipid of mitochondria) on the protein surface. Two of these CL binding sites reveal pathways linking CLs to the entrance of the D and H proton channels across CcO. CLs being able to carry protons our results strongly support an involvement of CLs in the proton delivery machinery to CcO. The ubiquitous nature of CL interactions with the components of the OxPhos suggests that this delivery mechanism might extend to the other respiratory complexes." @default.
• W2133885246 created "2016-06-24" @default.
• W2133885246 creator A5016032865 @default.
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• W2133885246 date "2013-02-12" @default.
• W2133885246 modified "2023-10-03" @default.
• W2133885246 title "Identification of cardiolipin binding sites on cytochrome c oxidase at the entrance of proton channels" @default.
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• W2133885246 doi "https://doi.org/10.1038/srep01263" @default.
• W2133885246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3579182" @default.
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• W2133885246 hasPublicationYear "2013" @default.
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