Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133898983> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2133898983 endingPage "619" @default.
- W2133898983 startingPage "615" @default.
- W2133898983 abstract "We determined the in vitro cytotoxic activity of the sesquiterpene lactone endoperoxide artemisinin (1) and some chemically prepared derivatives, which have been found to display cytotoxicity to cloned murine Ehrlich ascites tumour (EAT) cells and human HeLa cells and against murine bone marrow using a clonogenic assay for committed progenitor cells of the granulocyte-monocyte lineage (CFU-GM assay). Comparing artemisinin (1) to deoxyartemisinin (2), the endoperoxide group appeared to play a role in cytotoxicity to CFU-GM cells. Dimers of dihydroartemisinin and dihydrodeoxyartemisinin revealed that the stereochemistry of the ether linkage of the dimers was a more important determinant for this cytotoxic activity. The nonsymmetrical dimer of dihydroartemisinin (3) and the corresponding endoperoxide-lacking dimer of dihydrodeoxyartemisinin (5) were equally cytotoxic to CFU-GM cells. Despite the differences between both systems, it may be stated that most compounds displayed higher cytotoxicity to CFU-GM cells than to EAT cells. Dimers of dihydroartemisinin (3, 4) were selected as potential antitumour compounds and subjected to the National Cancer Institute drug-screening programme consisting of about sixty human cancer cell lines derived from nine different tissues. Both compounds displayed the same specific cytotoxicity pattern. Throughout the screen dimer 3 was more active than 4." @default.
- W2133898983 created "2016-06-24" @default.
- W2133898983 creator A5008887864 @default.
- W2133898983 creator A5010685831 @default.
- W2133898983 creator A5012872511 @default.
- W2133898983 creator A5031435238 @default.
- W2133898983 creator A5049305222 @default.
- W2133898983 creator A5054513755 @default.
- W2133898983 creator A5065831809 @default.
- W2133898983 creator A5069078301 @default.
- W2133898983 creator A5082432706 @default.
- W2133898983 date "1998-10-01" @default.
- W2133898983 modified "2023-09-26" @default.
- W2133898983 title "Artemisinin-Derived Sesquiterpene Lactones as Potential Antitumour Compounds: Cytotoxic Action against Bone Marrow and Tumour Cells" @default.
- W2133898983 doi "https://doi.org/10.1055/s-2006-957533" @default.
- W2133898983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9810267" @default.
- W2133898983 hasPublicationYear "1998" @default.
- W2133898983 type Work @default.
- W2133898983 sameAs 2133898983 @default.
- W2133898983 citedByCount "84" @default.
- W2133898983 countsByYear W21338989832012 @default.
- W2133898983 countsByYear W21338989832013 @default.
- W2133898983 countsByYear W21338989832014 @default.
- W2133898983 countsByYear W21338989832015 @default.
- W2133898983 countsByYear W21338989832016 @default.
- W2133898983 countsByYear W21338989832017 @default.
- W2133898983 countsByYear W21338989832018 @default.
- W2133898983 countsByYear W21338989832019 @default.
- W2133898983 countsByYear W21338989832020 @default.
- W2133898983 countsByYear W21338989832021 @default.
- W2133898983 countsByYear W21338989832022 @default.
- W2133898983 crossrefType "journal-article" @default.
- W2133898983 hasAuthorship W2133898983A5008887864 @default.
- W2133898983 hasAuthorship W2133898983A5010685831 @default.
- W2133898983 hasAuthorship W2133898983A5012872511 @default.
- W2133898983 hasAuthorship W2133898983A5031435238 @default.
- W2133898983 hasAuthorship W2133898983A5049305222 @default.
- W2133898983 hasAuthorship W2133898983A5054513755 @default.
- W2133898983 hasAuthorship W2133898983A5065831809 @default.
- W2133898983 hasAuthorship W2133898983A5069078301 @default.
- W2133898983 hasAuthorship W2133898983A5082432706 @default.
- W2133898983 hasConcept C109316439 @default.
- W2133898983 hasConcept C117262875 @default.
- W2133898983 hasConcept C153911025 @default.
- W2133898983 hasConcept C154317977 @default.
- W2133898983 hasConcept C185592680 @default.
- W2133898983 hasConcept C202751555 @default.
- W2133898983 hasConcept C203014093 @default.
- W2133898983 hasConcept C2776120307 @default.
- W2133898983 hasConcept C2776211264 @default.
- W2133898983 hasConcept C2777366897 @default.
- W2133898983 hasConcept C2778048844 @default.
- W2133898983 hasConcept C2778371730 @default.
- W2133898983 hasConcept C2779243328 @default.
- W2133898983 hasConcept C2780007613 @default.
- W2133898983 hasConcept C2781160685 @default.
- W2133898983 hasConcept C55493867 @default.
- W2133898983 hasConcept C71240020 @default.
- W2133898983 hasConcept C86803240 @default.
- W2133898983 hasConcept C98274493 @default.
- W2133898983 hasConceptScore W2133898983C109316439 @default.
- W2133898983 hasConceptScore W2133898983C117262875 @default.
- W2133898983 hasConceptScore W2133898983C153911025 @default.
- W2133898983 hasConceptScore W2133898983C154317977 @default.
- W2133898983 hasConceptScore W2133898983C185592680 @default.
- W2133898983 hasConceptScore W2133898983C202751555 @default.
- W2133898983 hasConceptScore W2133898983C203014093 @default.
- W2133898983 hasConceptScore W2133898983C2776120307 @default.
- W2133898983 hasConceptScore W2133898983C2776211264 @default.
- W2133898983 hasConceptScore W2133898983C2777366897 @default.
- W2133898983 hasConceptScore W2133898983C2778048844 @default.
- W2133898983 hasConceptScore W2133898983C2778371730 @default.
- W2133898983 hasConceptScore W2133898983C2779243328 @default.
- W2133898983 hasConceptScore W2133898983C2780007613 @default.
- W2133898983 hasConceptScore W2133898983C2781160685 @default.
- W2133898983 hasConceptScore W2133898983C55493867 @default.
- W2133898983 hasConceptScore W2133898983C71240020 @default.
- W2133898983 hasConceptScore W2133898983C86803240 @default.
- W2133898983 hasConceptScore W2133898983C98274493 @default.
- W2133898983 hasIssue "07" @default.
- W2133898983 hasLocation W21338989831 @default.
- W2133898983 hasOpenAccess W2133898983 @default.
- W2133898983 hasPrimaryLocation W21338989831 @default.
- W2133898983 hasRelatedWork W1609553144 @default.
- W2133898983 hasRelatedWork W2020052983 @default.
- W2133898983 hasRelatedWork W2133898983 @default.
- W2133898983 hasRelatedWork W2155481772 @default.
- W2133898983 hasRelatedWork W2162842262 @default.
- W2133898983 hasRelatedWork W2167107610 @default.
- W2133898983 hasRelatedWork W2261856173 @default.
- W2133898983 hasRelatedWork W2386043378 @default.
- W2133898983 hasRelatedWork W2891501243 @default.
- W2133898983 hasRelatedWork W3118679168 @default.
- W2133898983 hasVolume "64" @default.
- W2133898983 isParatext "false" @default.
- W2133898983 isRetracted "false" @default.
- W2133898983 magId "2133898983" @default.
- W2133898983 workType "article" @default.