FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133913547> ?p ?o ?g. }

• W2133913547 endingPage "136" @default.
• W2133913547 startingPage "132" @default.
• W2133913547 abstract "Chloroform has been shown to induce hepatocellular carcinomas in female B6C3F1 mice when administered by gavage, but not when given in drinking water. When administered in corn oil at the carcinogenic doses of 238 and 477 mg/kg, chloroform induced necrosis and sustained regenerative cell proliferation in the liver. To investigate the mode of action of tumor induction in the target cells, the ability of chloroform to induce unscheduled DNA synthesis (UDS) was examined in the in vitro and in vivo hepatocyte DNA repair assays. In the in vitro assay, primary hepatocyte cultures from female B6C3F1 mice were incubated with concentrations from 0.01 to 10 mM chloroform in the presence of 3H-thymidine. UDS was assessed by quantitative autoradiography. No induction of DNA repair was observed at any concentration. In the in vivo assay, animals were treated by gavage with 238 and 477 mg/kg chloroform in corn oil. Primary hepatocyte cultures were prepared 2 and 12 hr later, incubated with 3H-thymidine, and assessed for induction of UDS as above. No DNA repair activity was seen at either dose or at either timepoint. These negative results in the target organ are consistent with the concept that neither chloroform nor its metabolites are directly DNA reactive and that the carcinogenicity of chloroform is secondary to induced cytolethality and regenerative cell proliferation. © 1994 Wiley-Liss, Inc." @default.
• W2133913547 created "2016-06-24" @default.
• W2133913547 creator A5016170068 @default.
• W2133913547 creator A5017536476 @default.
• W2133913547 creator A5034120377 @default.
• W2133913547 date "1994-01-01" @default.
• W2133913547 modified "2023-10-16" @default.
• W2133913547 title "Lack of chloroform-induced DNA repair in vitro and in vivo in hepatocytes of female B6C3F1 mice" @default.
• W2133913547 cites W145522988 @default.
• W2133913547 cites W1523328993 @default.
• W2133913547 cites W1966670939 @default.
• W2133913547 cites W1980538953 @default.
• W2133913547 cites W1981661411 @default.
• W2133913547 cites W1991385782 @default.
• W2133913547 cites W1999497573 @default.
• W2133913547 cites W2000184823 @default.
• W2133913547 cites W2020036576 @default.
• W2133913547 cites W2035594562 @default.
• W2133913547 cites W2037382441 @default.
• W2133913547 cites W2041469915 @default.
• W2133913547 cites W2044613533 @default.
• W2133913547 cites W2063887332 @default.
• W2133913547 cites W2067219855 @default.
• W2133913547 cites W2076594361 @default.
• W2133913547 cites W2083984690 @default.
• W2133913547 cites W2090503172 @default.
• W2133913547 cites W2142233850 @default.
• W2133913547 cites W348052533 @default.
• W2133913547 cites W4231648772 @default.
• W2133913547 doi "https://doi.org/10.1002/em.2850230210" @default.
• W2133913547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8143701" @default.
• W2133913547 hasPublicationYear "1994" @default.
• W2133913547 type Work @default.
• W2133913547 sameAs 2133913547 @default.
• W2133913547 citedByCount "33" @default.
• W2133913547 countsByYear W21339135472012 @default.
• W2133913547 crossrefType "journal-article" @default.
• W2133913547 hasAuthorship W2133913547A5016170068 @default.
• W2133913547 hasAuthorship W2133913547A5017536476 @default.
• W2133913547 hasAuthorship W2133913547A5034120377 @default.
• W2133913547 hasConcept C114246631 @default.
• W2133913547 hasConcept C134018914 @default.
• W2133913547 hasConcept C134935766 @default.
• W2133913547 hasConcept C143425029 @default.
• W2133913547 hasConcept C153911025 @default.
• W2133913547 hasConcept C178790620 @default.
• W2133913547 hasConcept C185592680 @default.
• W2133913547 hasConcept C202751555 @default.
• W2133913547 hasConcept C207001950 @default.
• W2133913547 hasConcept C2776200302 @default.
• W2133913547 hasConcept C2777108182 @default.
• W2133913547 hasConcept C2778206080 @default.
• W2133913547 hasConcept C2781144210 @default.
• W2133913547 hasConcept C29730261 @default.
• W2133913547 hasConcept C43617362 @default.
• W2133913547 hasConcept C54355233 @default.
• W2133913547 hasConcept C552990157 @default.
• W2133913547 hasConcept C55493867 @default.
• W2133913547 hasConcept C62112901 @default.
• W2133913547 hasConcept C64241487 @default.
• W2133913547 hasConcept C86803240 @default.
• W2133913547 hasConceptScore W2133913547C114246631 @default.
• W2133913547 hasConceptScore W2133913547C134018914 @default.
• W2133913547 hasConceptScore W2133913547C134935766 @default.
• W2133913547 hasConceptScore W2133913547C143425029 @default.
• W2133913547 hasConceptScore W2133913547C153911025 @default.
• W2133913547 hasConceptScore W2133913547C178790620 @default.
• W2133913547 hasConceptScore W2133913547C185592680 @default.
• W2133913547 hasConceptScore W2133913547C202751555 @default.
• W2133913547 hasConceptScore W2133913547C207001950 @default.
• W2133913547 hasConceptScore W2133913547C2776200302 @default.
• W2133913547 hasConceptScore W2133913547C2777108182 @default.
• W2133913547 hasConceptScore W2133913547C2778206080 @default.
• W2133913547 hasConceptScore W2133913547C2781144210 @default.
• W2133913547 hasConceptScore W2133913547C29730261 @default.
• W2133913547 hasConceptScore W2133913547C43617362 @default.
• W2133913547 hasConceptScore W2133913547C54355233 @default.
• W2133913547 hasConceptScore W2133913547C552990157 @default.
• W2133913547 hasConceptScore W2133913547C55493867 @default.
• W2133913547 hasConceptScore W2133913547C62112901 @default.
• W2133913547 hasConceptScore W2133913547C64241487 @default.
• W2133913547 hasConceptScore W2133913547C86803240 @default.
• W2133913547 hasIssue "2" @default.
• W2133913547 hasLocation W21339135471 @default.
• W2133913547 hasLocation W21339135472 @default.
• W2133913547 hasOpenAccess W2133913547 @default.
• W2133913547 hasPrimaryLocation W21339135471 @default.
• W2133913547 hasRelatedWork W1555395060 @default.
• W2133913547 hasRelatedWork W2029370209 @default.
• W2133913547 hasRelatedWork W2029484071 @default.
• W2133913547 hasRelatedWork W2048682946 @default.
• W2133913547 hasRelatedWork W2049529530 @default.
• W2133913547 hasRelatedWork W2082053239 @default.
• W2133913547 hasRelatedWork W2133913547 @default.
• W2133913547 hasRelatedWork W2430808823 @default.
• W2133913547 hasRelatedWork W2767941096 @default.
• W2133913547 hasRelatedWork W4296502137 @default.
• W2133913547 hasVolume "23" @default.

• next