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• W2133939009 endingPage "1348" @default.
• W2133939009 startingPage "1343" @default.
• W2133939009 abstract "Mycobacterium bovis is the causative agent of bovine tuberculosis, a disease that is increasing in incidence in United Kingdom cattle herds. In addition to increasing economic losses, the rise in bovine tuberculosis poses a human health risk. There is an urgent requirement for effective strategies for disease eradication; this will likely involve vaccination in conjunction with current test and slaughter policies. A policy involving vaccination would require an accurate diagnosis of M. bovis-infected animals and the potential to distinguish these animals from vaccinates. Currently used diagnostic tests, the skin test and gamma interferon (IFN-gamma) blood test, have a sensitivity of up to 95%. A further complication is that M. bovis BCG-vaccinated animals are also scored positive by these tests. We tested the hypothesis that the quantification of IFN-gamma-producing lymphocytes by flow cytometric analysis of intracellular IFN-gamma expression would provide a more accurate discrimination of M. bovis-infected animals from BCG vaccinates. Significant numbers of IFN-gamma-expressing CD4+ T cells were detected following culture of heparinized blood from M. bovis-infected animals, but not from BCG vaccinates, with purified protein derived from M. bovis (PPD-B) or live mycobacteria. Only 1 of 17 BCG-vaccinated animals had a significant number of CD4+ T lymphocytes expressing IFN-gamma, compared with 21/22 M. bovis-infected animals. This assay could allow an accurate diagnosis of M. bovis and allow the discrimination of BCG-vaccinated cattle from infected cattle." @default.
• W2133939009 created "2016-06-24" @default.
• W2133939009 creator A5016868088 @default.
• W2133939009 creator A5052535501 @default.
• W2133939009 creator A5073650344 @default.
• W2133939009 date "2006-12-01" @default.
• W2133939009 modified "2023-09-23" @default.
• W2133939009 title "Flow Cytometric Detection of Gamma Interferon Can Effectively Discriminate<i>Mycobacterium bovis</i>BCG-Vaccinated Cattle from<i>M. bovis</i>-Infected Cattle" @default.
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• W2133939009 doi "https://doi.org/10.1128/cvi.00291-06" @default.
• W2133939009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1694452" @default.
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