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• W2133961805 endingPage "721" @default.
• W2133961805 startingPage "715" @default.
• W2133961805 abstract "In humans, approximately 90% of saliva is secreted by the 3 major salivary glands: the parotid (PG), the submandibular (SMG), and the sublingual glands (SLG). Even though it is known that all 3 major salivary glands secrete saliva by a Cl - -dependent mechanism, salivary secretion rates differ greatly among these glands. The goal of this study was to gain insight into the properties of the ion-transporting pathways in acinar cells that might account for the differences among the major salivary glands. Pilocarpine-induced saliva was simultaneously collected in vivo from the 3 major salivary glands of mice. When normalized by gland weight, the amount of saliva secreted by the PG was more than 2-fold larger than that obtained from the SMG and SLG. At the cellular level, carbachol induced an increase in the intracellular [Ca 2+ ] that was more than 2-fold larger in PG and SMG than in SLG acinar cells. Carbachol-stimulated Cl - efflux and the protein levels of the Ca 2+ -activated Cl - channel TMEM16A, the major apical Cl - efflux pathway in salivary acinar cells, were significantly greater in PG compared with SMG and SLG. In addition, we evaluated the transporter activity of the Na + -K + -2Cl - cotransporters (NKCC1) and anion exchangers (AE), the 2 primary basolateral Cl - uptake mechanisms in acinar cells. The SMG NKCC1 activity was about twice that of the PG and more than 12-fold greater than that of the SLG. AE activity was similar in PG and SLG, and both PG and SLG AE activity was about 2-fold larger than that of SMG. In summary, the salivation kinetics of the 3 major glands are distinct, and these differences can be explained by the unique functional properties of each gland related to Cl - movement, including the transporter activities of the Cl - uptake and efflux pathways, and intracellular Ca 2+ mobilization." @default.
• W2133961805 created "2016-06-24" @default.
• W2133961805 creator A5055277847 @default.
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• W2133961805 date "2015-02-13" @default.
• W2133961805 modified "2023-10-16" @default.
• W2133961805 title "Functional Differences in the Acinar Cells of the Murine Major Salivary Glands" @default.
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• W2133961805 doi "https://doi.org/10.1177/0022034515570943" @default.
• W2133961805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4502782" @default.
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• W2133961805 hasPublicationYear "2015" @default.
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