Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133973371> ?p ?o ?g. }
- W2133973371 endingPage "1478" @default.
- W2133973371 startingPage "1468" @default.
- W2133973371 abstract "Neurobehavioral symptoms are frequently reported in patients with diabetes. Nevertheless, the characterization of the specific symptom dimensions that develop in diabetic patients with respect to disease phenotype and treatment status remains obscure. This study comparatively assessed fatigue symptoms and cognitive performance using a dimensional approach in 21 patients with insulin-treated type 1 diabetes, 24 type 2 diabetic patients either insulin-free or undergoing insulin treatment for at least six months, and 15 healthy subjects. Specific dimensions of fatigue were assessed using the Multidimensional-Fatigue-Inventory (MFI). Cognitive performance on tests of choice reaction time, pattern recognition memory and spatial planning was evaluated using the Cambridge-Neuropsychological-Automated-Battery (CANTAB). Body mass index (BMI) and glycated-hemoglobin (HbA1C) concentrations were collected, as well as information on diabetes complications and disease duration. Patients with type 2 diabetes, regardless of insulin treatment status, exhibited higher scores of fatigue, primarily in the dimensions of general and physical fatigue as well as reduced activity. Cognitive alterations, in the form of longer reaction times and impaired spatial planning, were also detected in type 2 diabetic patients treated with insulin. These alterations were overall unrelated to glucose control, as reflected in HbA1C levels, and were not explained by complications and duration of diabetes. No specific alteration was measured in type 1 diabetic patients who exhibited fatigue scores and cognitive performance comparable to healthy participants. While associated with fatigue, increased BMI did not significantly account for the relationship of type 2 diabetes with general fatigue and physical fatigue. BMI, however, modulated the association of type 2 diabetes with reduced activity and the association of insulin-treated type 2 diabetes with psychomotor slowing. These findings reveal specific fatigue and cognitive symptoms in patients with type 2 diabetes and suggest the involvement of differential pathophysiological processes." @default.
- W2133973371 created "2016-06-24" @default.
- W2133973371 creator A5054040611 @default.
- W2133973371 creator A5062064926 @default.
- W2133973371 creator A5069181444 @default.
- W2133973371 creator A5070522156 @default.
- W2133973371 creator A5076246432 @default.
- W2133973371 creator A5080253120 @default.
- W2133973371 creator A5083204765 @default.
- W2133973371 date "2012-09-01" @default.
- W2133973371 modified "2023-09-26" @default.
- W2133973371 title "Fatigue and cognitive symptoms in patients with diabetes: Relationship with disease phenotype and insulin treatment" @default.
- W2133973371 cites W1627446849 @default.
- W2133973371 cites W1963734433 @default.
- W2133973371 cites W1969065116 @default.
- W2133973371 cites W1970665848 @default.
- W2133973371 cites W1975537939 @default.
- W2133973371 cites W1976313368 @default.
- W2133973371 cites W1987088208 @default.
- W2133973371 cites W1993642953 @default.
- W2133973371 cites W1998099581 @default.
- W2133973371 cites W1998429379 @default.
- W2133973371 cites W2003239266 @default.
- W2133973371 cites W2004045452 @default.
- W2133973371 cites W2005149888 @default.
- W2133973371 cites W2013952491 @default.
- W2133973371 cites W2015131633 @default.
- W2133973371 cites W2025272839 @default.
- W2133973371 cites W2031920964 @default.
- W2133973371 cites W2035121795 @default.
- W2133973371 cites W2044248209 @default.
- W2133973371 cites W2045948263 @default.
- W2133973371 cites W2055174117 @default.
- W2133973371 cites W2057702509 @default.
- W2133973371 cites W2057920967 @default.
- W2133973371 cites W2063105320 @default.
- W2133973371 cites W2063139961 @default.
- W2133973371 cites W2068185418 @default.
- W2133973371 cites W2072184805 @default.
- W2133973371 cites W2073097524 @default.
- W2133973371 cites W2073717326 @default.
- W2133973371 cites W2073977794 @default.
- W2133973371 cites W2076725316 @default.
- W2133973371 cites W2080205372 @default.
- W2133973371 cites W2099660567 @default.
- W2133973371 cites W2107406042 @default.
- W2133973371 cites W2107884508 @default.
- W2133973371 cites W2109006772 @default.
- W2133973371 cites W2120479022 @default.
- W2133973371 cites W2120861740 @default.
- W2133973371 cites W2121339320 @default.
- W2133973371 cites W2125598893 @default.
- W2133973371 cites W2131823335 @default.
- W2133973371 cites W2132072073 @default.
- W2133973371 cites W2132520944 @default.
- W2133973371 cites W2136800398 @default.
- W2133973371 cites W2137404207 @default.
- W2133973371 cites W2140634406 @default.
- W2133973371 cites W2145451941 @default.
- W2133973371 cites W2147572724 @default.
- W2133973371 cites W2148462509 @default.
- W2133973371 cites W2156600347 @default.
- W2133973371 cites W2156640925 @default.
- W2133973371 cites W2166722689 @default.
- W2133973371 cites W2168269952 @default.
- W2133973371 cites W2171969403 @default.
- W2133973371 cites W2316108515 @default.
- W2133973371 doi "https://doi.org/10.1016/j.psyneuen.2012.01.016" @default.
- W2133973371 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22370460" @default.
- W2133973371 hasPublicationYear "2012" @default.
- W2133973371 type Work @default.
- W2133973371 sameAs 2133973371 @default.
- W2133973371 citedByCount "34" @default.
- W2133973371 countsByYear W21339733712012 @default.
- W2133973371 countsByYear W21339733712013 @default.
- W2133973371 countsByYear W21339733712014 @default.
- W2133973371 countsByYear W21339733712015 @default.
- W2133973371 countsByYear W21339733712016 @default.
- W2133973371 countsByYear W21339733712017 @default.
- W2133973371 countsByYear W21339733712018 @default.
- W2133973371 countsByYear W21339733712019 @default.
- W2133973371 countsByYear W21339733712020 @default.
- W2133973371 countsByYear W21339733712021 @default.
- W2133973371 countsByYear W21339733712022 @default.
- W2133973371 countsByYear W21339733712023 @default.
- W2133973371 crossrefType "journal-article" @default.
- W2133973371 hasAuthorship W2133973371A5054040611 @default.
- W2133973371 hasAuthorship W2133973371A5062064926 @default.
- W2133973371 hasAuthorship W2133973371A5069181444 @default.
- W2133973371 hasAuthorship W2133973371A5070522156 @default.
- W2133973371 hasAuthorship W2133973371A5076246432 @default.
- W2133973371 hasAuthorship W2133973371A5080253120 @default.
- W2133973371 hasAuthorship W2133973371A5083204765 @default.
- W2133973371 hasConcept C118552586 @default.
- W2133973371 hasConcept C126322002 @default.
- W2133973371 hasConcept C134018914 @default.
- W2133973371 hasConcept C14216870 @default.
- W2133973371 hasConcept C169900460 @default.