Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133997960> ?p ?o ?g. }
- W2133997960 endingPage "1720" @default.
- W2133997960 startingPage "1711" @default.
- W2133997960 abstract "Memory T lymphocytes proliferate in vivo in the absence of antigen maintaining a pool of central memory T cells (T(CM)) and effector memory T cells (T(EM)) with distinct effector function and homing capacity. We compared human CD4(+) naive T, T(CM), and T(EM) cells for their capacity to proliferate in response to cytokines, that have been implicated in T cell homeostasis. Interleukin (IL)-7 and IL-15 expanded with very high efficiency T(EM), while T(CM) were less responsive and naive T cells failed to respond. Dendritic cells (DCs) and DC-derived cytokines allowed naive T cells to proliferate selectively in response to IL-4, and potently boosted the response of T(CM) to IL-7 and IL-15 by increasing the expression of the IL-2/IL-15Rbeta and the common gamma chain (gamma(c)). The extracellular signal regulated kinase and the p38 mitogen-activated protein (MAP) kinases were selectively required for TCR and cytokine-driven proliferation, respectively. Importantly, in cytokine-driven cultures, some of the proliferating T(CM) differentiated to T(EM)-like cells acquiring effector function and switching chemokine receptor expression from CCR7 to CCR5. The sustained antigen-independent generation of T(EM) from a pool of T(CM) cells provides a plausible mechanism for the maintenance of a polyclonal and functionally diverse repertoire of human CD4(+) memory T cells." @default.
- W2133997960 created "2016-06-24" @default.
- W2133997960 creator A5020503463 @default.
- W2133997960 creator A5047171254 @default.
- W2133997960 creator A5059965999 @default.
- W2133997960 date "2001-12-10" @default.
- W2133997960 modified "2023-10-16" @default.
- W2133997960 title "Cytokine-driven Proliferation and Differentiation of Human Naive, Central Memory, and Effector Memory CD4+ T Cells" @default.
- W2133997960 cites W1521515468 @default.
- W2133997960 cites W1537543309 @default.
- W2133997960 cites W1544307647 @default.
- W2133997960 cites W1585450293 @default.
- W2133997960 cites W1601504908 @default.
- W2133997960 cites W1610017743 @default.
- W2133997960 cites W1763148533 @default.
- W2133997960 cites W1946381923 @default.
- W2133997960 cites W1964036834 @default.
- W2133997960 cites W1966432380 @default.
- W2133997960 cites W1972626855 @default.
- W2133997960 cites W1979751962 @default.
- W2133997960 cites W1980785340 @default.
- W2133997960 cites W1981480494 @default.
- W2133997960 cites W1997196319 @default.
- W2133997960 cites W1999685520 @default.
- W2133997960 cites W2001036909 @default.
- W2133997960 cites W2003717645 @default.
- W2133997960 cites W2004143904 @default.
- W2133997960 cites W2006027051 @default.
- W2133997960 cites W2006981670 @default.
- W2133997960 cites W2008366157 @default.
- W2133997960 cites W2009630518 @default.
- W2133997960 cites W2022477357 @default.
- W2133997960 cites W2025465431 @default.
- W2133997960 cites W2028091596 @default.
- W2133997960 cites W2039505354 @default.
- W2133997960 cites W2040066315 @default.
- W2133997960 cites W2040532931 @default.
- W2133997960 cites W2045720698 @default.
- W2133997960 cites W2047528341 @default.
- W2133997960 cites W2047945116 @default.
- W2133997960 cites W2048565768 @default.
- W2133997960 cites W2054678965 @default.
- W2133997960 cites W2055555686 @default.
- W2133997960 cites W2062892166 @default.
- W2133997960 cites W2079135245 @default.
- W2133997960 cites W2081097093 @default.
- W2133997960 cites W2091217693 @default.
- W2133997960 cites W2095905668 @default.
- W2133997960 cites W2107225522 @default.
- W2133997960 cites W2121870374 @default.
- W2133997960 cites W2125650988 @default.
- W2133997960 cites W2130098661 @default.
- W2133997960 cites W2131746203 @default.
- W2133997960 cites W2136358628 @default.
- W2133997960 cites W2137384756 @default.
- W2133997960 cites W2158270563 @default.
- W2133997960 cites W2160430737 @default.
- W2133997960 cites W2163955606 @default.
- W2133997960 cites W2270208951 @default.
- W2133997960 cites W4211059834 @default.
- W2133997960 cites W4249383241 @default.
- W2133997960 doi "https://doi.org/10.1084/jem.194.12.1711" @default.
- W2133997960 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2193568" @default.
- W2133997960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11748273" @default.
- W2133997960 hasPublicationYear "2001" @default.
- W2133997960 type Work @default.
- W2133997960 sameAs 2133997960 @default.
- W2133997960 citedByCount "515" @default.
- W2133997960 countsByYear W21339979602012 @default.
- W2133997960 countsByYear W21339979602013 @default.
- W2133997960 countsByYear W21339979602014 @default.
- W2133997960 countsByYear W21339979602015 @default.
- W2133997960 countsByYear W21339979602016 @default.
- W2133997960 countsByYear W21339979602017 @default.
- W2133997960 countsByYear W21339979602018 @default.
- W2133997960 countsByYear W21339979602019 @default.
- W2133997960 countsByYear W21339979602020 @default.
- W2133997960 countsByYear W21339979602021 @default.
- W2133997960 countsByYear W21339979602022 @default.
- W2133997960 countsByYear W21339979602023 @default.
- W2133997960 crossrefType "journal-article" @default.
- W2133997960 hasAuthorship W2133997960A5020503463 @default.
- W2133997960 hasAuthorship W2133997960A5047171254 @default.
- W2133997960 hasAuthorship W2133997960A5059965999 @default.
- W2133997960 hasBestOaLocation W21339979601 @default.
- W2133997960 hasConcept C116484652 @default.
- W2133997960 hasConcept C120642132 @default.
- W2133997960 hasConcept C129374314 @default.
- W2133997960 hasConcept C131665280 @default.
- W2133997960 hasConcept C148125776 @default.
- W2133997960 hasConcept C154317977 @default.
- W2133997960 hasConcept C19317047 @default.
- W2133997960 hasConcept C202751555 @default.
- W2133997960 hasConcept C203014093 @default.
- W2133997960 hasConcept C2775982045 @default.
- W2133997960 hasConcept C2776090121 @default.
- W2133997960 hasConcept C2777367678 @default.
- W2133997960 hasConcept C2778690821 @default.