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- W2133999780 abstract "Chimeric antigen receptor (CAR) based immunotherapy has been under development for the last 25 years and is now a promising new treatment modality in the field of cancer immunotherapy. The approach involves genetically engineering T cells to target malignant cells through expression of a bespoke fusion receptor that couples an HLA-independent antigen recognition domain to one or more intracellular T-cell activating modules. Multiple clinical trials are now underway in several centers to investigate CAR T-cell immunotherapy of diverse hematologic and solid tumor types. The most successful results have been achieved in the treatment of patients with B-cell malignancies, in whom several complete and durable responses have been achieved. This review focuses on the preclinical and clinical development of CAR T-cell immunotherapy of solid cancers, targeted against members of the ErbB family." @default.
- W2133999780 created "2016-06-24" @default.
- W2133999780 creator A5046363597 @default.
- W2133999780 creator A5053670839 @default.
- W2133999780 date "2015-03-01" @default.
- W2133999780 modified "2023-09-28" @default.
- W2133999780 title "ErbB-targeted CAR T-cell immunotherapy of cancer" @default.
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- W2133999780 doi "https://doi.org/10.2217/imt.14.120" @default.
- W2133999780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25804476" @default.
- W2133999780 hasPublicationYear "2015" @default.
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