Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134023650> ?p ?o ?g. }
- W2134023650 endingPage "280" @default.
- W2134023650 startingPage "267" @default.
- W2134023650 abstract "Ficolin-1 (M), ficolin-2 (L), ficolin-3 (H) and mannan-binding lectin (MBL) activate the complement system and have opsonic activity. The specificity of ficolin-3 is poorly characterized and currently limited to a few ligands only. We present new specific targets for human ficolin-3, identified among lipopolysaccharides (LPSs, endotoxin) of Hafnia alvei. The interaction was restricted to LPSs of four strains: 23, Polish Collection of Microorganisms (PCM) 1200, PCM 1203 and PCM 1205 and limited to their O-specific polysaccharides (O-specific PSs) composed of different numbers of oligosaccharide (OS) repeating units (RUs). Moreover, these LPS/ficolin-3 complexes activated the lectin pathway of complement in a C4b-deposition assay in a calcium- and magnesium-dependent way. A neoglycoconjugate of the O-specific PS fraction of H. alvei 1200 LPS with bovine serum albumin (BSA) was prepared and used as a tool for the determination of ficolin-3 concentration and activity in serum. To confirm a structure of the O-specific PS 1200 selected for the conjugate preparation, structural analysis was performed on a series of O-specific PSs released by the mild acid hydrolysis of the LPS. The isolated O-specific PSs, showing the different length distributions, were devoid of a major part of the core OS region and had Hep-Kdo disaccharide at a reducing end. The neoglycoconjugate was a highly selective tool for the determination of ficolin-3 concentration and activity in serum (lectin pathway activation in the C4b deposition assay) and was not affected by MBL, ficolin-1 and ficolin-2 or natural antibodies." @default.
- W2134023650 created "2016-06-24" @default.
- W2134023650 creator A5008762439 @default.
- W2134023650 creator A5009306852 @default.
- W2134023650 creator A5020375164 @default.
- W2134023650 creator A5050765185 @default.
- W2134023650 creator A5055343750 @default.
- W2134023650 creator A5065945272 @default.
- W2134023650 creator A5067613836 @default.
- W2134023650 creator A5083485864 @default.
- W2134023650 date "2011-09-02" @default.
- W2134023650 modified "2023-10-10" @default.
- W2134023650 title "New functional ligands for ficolin-3 among lipopolysaccharides of Hafnia alvei" @default.
- W2134023650 cites W1589924427 @default.
- W2134023650 cites W1611779324 @default.
- W2134023650 cites W1894781817 @default.
- W2134023650 cites W1961321585 @default.
- W2134023650 cites W1966052933 @default.
- W2134023650 cites W1971164742 @default.
- W2134023650 cites W1978786706 @default.
- W2134023650 cites W1985064057 @default.
- W2134023650 cites W1986616655 @default.
- W2134023650 cites W1988351744 @default.
- W2134023650 cites W1994164445 @default.
- W2134023650 cites W2005131788 @default.
- W2134023650 cites W2013839711 @default.
- W2134023650 cites W2015351663 @default.
- W2134023650 cites W2015371417 @default.
- W2134023650 cites W2023682375 @default.
- W2134023650 cites W2024541829 @default.
- W2134023650 cites W2037239046 @default.
- W2134023650 cites W2037775811 @default.
- W2134023650 cites W2042243650 @default.
- W2134023650 cites W2042245036 @default.
- W2134023650 cites W2042740495 @default.
- W2134023650 cites W2043045389 @default.
- W2134023650 cites W2045312983 @default.
- W2134023650 cites W2046286932 @default.
- W2134023650 cites W2057150696 @default.
- W2134023650 cites W2057217334 @default.
- W2134023650 cites W2057649456 @default.
- W2134023650 cites W2064718789 @default.
- W2134023650 cites W2066582706 @default.
- W2134023650 cites W2066863938 @default.
- W2134023650 cites W2073417974 @default.
- W2134023650 cites W2076355231 @default.
- W2134023650 cites W2079413893 @default.
- W2134023650 cites W2083783493 @default.
- W2134023650 cites W2084138453 @default.
- W2134023650 cites W2085277204 @default.
- W2134023650 cites W2085526527 @default.
- W2134023650 cites W2089135776 @default.
- W2134023650 cites W2090162049 @default.
- W2134023650 cites W2091575744 @default.
- W2134023650 cites W2093471951 @default.
- W2134023650 cites W2100837269 @default.
- W2134023650 cites W2108563067 @default.
- W2134023650 cites W2120947093 @default.
- W2134023650 cites W2129991557 @default.
- W2134023650 cites W2147985190 @default.
- W2134023650 cites W2155705671 @default.
- W2134023650 cites W2171747026 @default.
- W2134023650 cites W2172296955 @default.
- W2134023650 cites W2220554655 @default.
- W2134023650 cites W4234317413 @default.
- W2134023650 doi "https://doi.org/10.1093/glycob/cwr119" @default.
- W2134023650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21890891" @default.
- W2134023650 hasPublicationYear "2011" @default.
- W2134023650 type Work @default.
- W2134023650 sameAs 2134023650 @default.
- W2134023650 citedByCount "37" @default.
- W2134023650 countsByYear W21340236502012 @default.
- W2134023650 countsByYear W21340236502013 @default.
- W2134023650 countsByYear W21340236502014 @default.
- W2134023650 countsByYear W21340236502015 @default.
- W2134023650 countsByYear W21340236502016 @default.
- W2134023650 countsByYear W21340236502018 @default.
- W2134023650 countsByYear W21340236502019 @default.
- W2134023650 countsByYear W21340236502020 @default.
- W2134023650 countsByYear W21340236502021 @default.
- W2134023650 countsByYear W21340236502022 @default.
- W2134023650 crossrefType "journal-article" @default.
- W2134023650 hasAuthorship W2134023650A5008762439 @default.
- W2134023650 hasAuthorship W2134023650A5009306852 @default.
- W2134023650 hasAuthorship W2134023650A5020375164 @default.
- W2134023650 hasAuthorship W2134023650A5050765185 @default.
- W2134023650 hasAuthorship W2134023650A5055343750 @default.
- W2134023650 hasAuthorship W2134023650A5065945272 @default.
- W2134023650 hasAuthorship W2134023650A5067613836 @default.
- W2134023650 hasAuthorship W2134023650A5083485864 @default.
- W2134023650 hasBestOaLocation W21340236501 @default.
- W2134023650 hasConcept C108625454 @default.
- W2134023650 hasConcept C111684460 @default.
- W2134023650 hasConcept C124594742 @default.
- W2134023650 hasConcept C159654299 @default.
- W2134023650 hasConcept C171279029 @default.
- W2134023650 hasConcept C185592680 @default.
- W2134023650 hasConcept C189413060 @default.