FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134026908> ?p ?o ?g. }

• W2134026908 endingPage "375" @default.
• W2134026908 startingPage "369" @default.
• W2134026908 abstract "Arylamine <i>N</i>-acetyltransferases (NATs; EC 2.3.1.5) catalyze both the <i>N</i>-acetylation and <i>O</i>-acetylation of arylamines and <i>N</i>-hydroxyarylamines. Humans possess two functional <i>N</i>-acetyltransferase genes, <i>NAT1</i> and <i>NAT2</i>, as well as a nonfunctional pseudogene, <i>NATP</i>. Previous studies have identified <i>Nat1</i> and <i>Nat2</i> genes in the rat. In this study, we identified and characterized a third rat <i>N</i>-acetyltransferase gene (<i>Nat3</i>) consisting of a single open reading frame of 870 base pairs encoding a 290-amino acid protein, analogous to the previously identified human and rat <i>N</i>-acetyltransferase genes. Rat <i>Nat3</i> nucleotide sequence was 77.2 and 75.9% identical to human <i>NAT1</i> and <i>NAT2</i>, respectively. Rat Nat3 amino acid sequence was 68.6 and 67.2% identical to human NAT1 and NAT2, respectively. Rat <i>Nat1</i>, <i>Nat2</i>, and <i>Nat3</i> were each cloned and recombinantly expressed in <i>Escherichia coli</i>. Recombinant rat Nat3 exhibited thermostability intermediate between recombinant rat Nat1 and Nat2. Recombinant rat Nat3 was functional and catalyzed the <i>N</i>-acetylation of several arylamine substrates, including 3-ethylaniline, 3,5-dimethylaniline, 5-aminosalicylic acid, 4-aminobiphenyl, 4,4′-methylenedianiline, 4,4′-methylenebis(2-chloroaniline), and 2-aminofluorene, and the <i>O</i>-acetylation of <i>N</i>-hydroxy-4-aminobiphenyl. The relative affinities of arylamine carcinogens such as 4-aminobiphenyl, <i>N</i>-hydroxy-4-aminobiphenyl, and 2-aminofluorene for <i>N</i>- and <i>O</i>-acetylation via recombinant rat Nat3 were comparable with recombinant rat Nat1 and higher than for recombinant rat Nat2. This study is the first to report a third arylamine <i>N</i>-acetyltransferase isozyme with significant functional capacity." @default.
• W2134026908 created "2016-06-24" @default.
• W2134026908 creator A5014517451 @default.
• W2134026908 creator A5057713019 @default.
• W2134026908 creator A5086028523 @default.
• W2134026908 date "2006-07-07" @default.
• W2134026908 modified "2023-10-12" @default.
• W2134026908 title "Identification and Characterization of Functional Rat Arylamine <i>N</i>-Acetyltransferase 3: Comparisons with Rat Arylamine <i>N</i>-Acetyltransferases 1 and 2" @default.
• W2134026908 cites W1569071713 @default.
• W2134026908 cites W1882310631 @default.
• W2134026908 cites W1906630699 @default.
• W2134026908 cites W1913137623 @default.
• W2134026908 cites W1969021925 @default.
• W2134026908 cites W1975920595 @default.
• W2134026908 cites W1978494123 @default.
• W2134026908 cites W1980571658 @default.
• W2134026908 cites W1983116428 @default.
• W2134026908 cites W1983740032 @default.
• W2134026908 cites W1992819762 @default.
• W2134026908 cites W1996423252 @default.
• W2134026908 cites W2024057264 @default.
• W2134026908 cites W2042503727 @default.
• W2134026908 cites W2045492912 @default.
• W2134026908 cites W2053867451 @default.
• W2134026908 cites W2062426104 @default.
• W2134026908 cites W2063160368 @default.
• W2134026908 cites W2064234321 @default.
• W2134026908 cites W2069890113 @default.
• W2134026908 cites W2083944497 @default.
• W2134026908 cites W2084185692 @default.
• W2134026908 cites W2093714545 @default.
• W2134026908 cites W2095256997 @default.
• W2134026908 cites W2096525273 @default.
• W2134026908 cites W2126469789 @default.
• W2134026908 cites W2128635872 @default.
• W2134026908 cites W2128739919 @default.
• W2134026908 cites W2136145671 @default.
• W2134026908 cites W2136491105 @default.
• W2134026908 cites W2138916948 @default.
• W2134026908 cites W2149298729 @default.
• W2134026908 cites W2160043058 @default.
• W2134026908 cites W2160219745 @default.
• W2134026908 cites W2182953926 @default.
• W2134026908 cites W2415326388 @default.
• W2134026908 cites W4245803912 @default.
• W2134026908 cites W4293247451 @default.
• W2134026908 cites W626666553 @default.
• W2134026908 doi "https://doi.org/10.1124/jpet.106.108399" @default.
• W2134026908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16829624" @default.
• W2134026908 hasPublicationYear "2006" @default.
• W2134026908 type Work @default.
• W2134026908 sameAs 2134026908 @default.
• W2134026908 citedByCount "28" @default.
• W2134026908 countsByYear W21340269082012 @default.
• W2134026908 countsByYear W21340269082014 @default.
• W2134026908 countsByYear W21340269082015 @default.
• W2134026908 countsByYear W21340269082016 @default.
• W2134026908 countsByYear W21340269082017 @default.
• W2134026908 countsByYear W21340269082018 @default.
• W2134026908 countsByYear W21340269082020 @default.
• W2134026908 crossrefType "journal-article" @default.
• W2134026908 hasAuthorship W2134026908A5014517451 @default.
• W2134026908 hasAuthorship W2134026908A5057713019 @default.
• W2134026908 hasAuthorship W2134026908A5086028523 @default.
• W2134026908 hasConcept C104317684 @default.
• W2134026908 hasConcept C119157956 @default.
• W2134026908 hasConcept C153911025 @default.
• W2134026908 hasConcept C167625842 @default.
• W2134026908 hasConcept C185592680 @default.
• W2134026908 hasConcept C2778328694 @default.
• W2134026908 hasConcept C2778340702 @default.
• W2134026908 hasConcept C2779649592 @default.
• W2134026908 hasConcept C2910274206 @default.
• W2134026908 hasConcept C40767141 @default.
• W2134026908 hasConcept C47289529 @default.
• W2134026908 hasConcept C515207424 @default.
• W2134026908 hasConcept C547475151 @default.
• W2134026908 hasConcept C55493867 @default.
• W2134026908 hasConcept C86803240 @default.
• W2134026908 hasConceptScore W2134026908C104317684 @default.
• W2134026908 hasConceptScore W2134026908C119157956 @default.
• W2134026908 hasConceptScore W2134026908C153911025 @default.
• W2134026908 hasConceptScore W2134026908C167625842 @default.
• W2134026908 hasConceptScore W2134026908C185592680 @default.
• W2134026908 hasConceptScore W2134026908C2778328694 @default.
• W2134026908 hasConceptScore W2134026908C2778340702 @default.
• W2134026908 hasConceptScore W2134026908C2779649592 @default.
• W2134026908 hasConceptScore W2134026908C2910274206 @default.
• W2134026908 hasConceptScore W2134026908C40767141 @default.
• W2134026908 hasConceptScore W2134026908C47289529 @default.
• W2134026908 hasConceptScore W2134026908C515207424 @default.
• W2134026908 hasConceptScore W2134026908C547475151 @default.
• W2134026908 hasConceptScore W2134026908C55493867 @default.
• W2134026908 hasConceptScore W2134026908C86803240 @default.
• W2134026908 hasIssue "1" @default.
• W2134026908 hasLocation W21340269081 @default.
• W2134026908 hasLocation W21340269082 @default.
• W2134026908 hasOpenAccess W2134026908 @default.

• next