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- W2134028992 abstract "Stimulation of human epithelial cells with IL-1 (10 ng/ml) + UVB radiation results in sustained NFκB activation caused by continuous IKKβ phosphorylation. We have recently published a strictly reduced ordinary differential equation model elucidating the involved mechanisms. Here, we compare model extensions for low IL-1 doses (0.5 ng/ml), where delayed IKKβ phosphorylation is observed. The extended model including a positive regulatory element, most likely auto-ubiquitination of TRAF6, reproduces the observed experimental data most convincingly. The extension is shown to be consistent with the original model and contains very sensitive processes which may serve as potential intervention targets." @default.
- W2134028992 created "2016-06-24" @default.
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- W2134028992 date "2011-06-17" @default.
- W2134028992 modified "2023-09-23" @default.
- W2134028992 title "Modeling time delay in the NFκB signaling pathway following low dose IL-1 stimulation" @default.
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- W2134028992 doi "https://doi.org/10.1186/1687-4153-2011-3" @default.
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