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• W2134029042 endingPage "1322" @default.
• W2134029042 startingPage "1317" @default.
• W2134029042 abstract "Objective— The di-leucine motif exists in the intracellular domains of certain cell surface receptors, participating in the receptor-mediated endocytosis. The present study was aimed at determining the role of the di-leucine motif in class A scavenger receptor (SR-A)-mediated ligand endocytosis. Methods and Results— cDNA coding for a mutant (SR-A mutant N3132LM) with deletion of the di-leucine structure was transfected into Chinese hamster ovary (CHO) cells. Compared with wild-type SR-A–expressing cells, the cells expressing the SR-A mutant N3132LM showed a significant decrease in uptake but almost no change in binding of the SR-A ligand acetylated low-density lipoprotein (AcLDL). Western blot analysis revealed coimmunoprecipitation of SR-A mutant and clathrin from the lysates of the mutant but not wild-type CHO cells, suggesting that AcLDL-bound SR-A mutant N3132LM is associated with the clathrin-coated pit of cellular membrane. Removal of the first 27 amino acid residues from the SR-A N-terminus further reduced AcLDL uptake by the cells with the di-leucine motif mutation. Conclusions— The di-leucine motif of SR-A intracellular domain contributes to the SR-A–mediated cellular internalization of AcLDL. Di-leucine pair exists in the cytoplasmic domain of class A scavenger receptor. The cells expressing di-leucine mutants showed decreased uptake and unchanged binding of AcLDL. The di-leucine pair was not associated to coated pits. It suggests that di-leucine motif acts as a signal sequence to mediate SR-A into cell." @default.
• W2134029042 created "2016-06-24" @default.
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• W2134029042 date "2006-06-01" @default.
• W2134029042 modified "2023-10-17" @default.
• W2134029042 title "The Di-Leucine Motif Contributes to Class A Scavenger Receptor-Mediated Internalization of Acetylated Lipoproteins" @default.
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• W2134029042 doi "https://doi.org/10.1161/01.atv.0000220171.50282.0c" @default.
• W2134029042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16574888" @default.
• W2134029042 hasPublicationYear "2006" @default.
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