Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134031196> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2134031196 endingPage "896" @default.
- W2134031196 startingPage "891" @default.
- W2134031196 abstract "Protein engineering of the beta-propeller protein aimed at enhancing the structural stability of the protein was carried out using a monomeric single domain beta-propeller protein, Salmonella typhimurium sialidase, as a model. Ala53 and Ala69 each located at strands B and C of the W1 motif were mutated to Leu and Val, respectively, to increase the hydrophobic interaction between W1 and W6 motifs. The mutants showed enhanced stability towards guanidine hydrochloride and thermal unfolding. Ala53Leu showed higher stability, probably owing to the capability of the mutated Leu to interact extensively with more residues involved in the hydrophobic interactions between the terminal W-motifs. The mutations, which are located far from the active site, have no significant effect on the enzymatic properties. The strategy to enhance the stability proposed here might be applied to the other beta-propeller proteins." @default.
- W2134031196 created "2016-06-24" @default.
- W2134031196 creator A5013641148 @default.
- W2134031196 creator A5029088690 @default.
- W2134031196 date "2001-11-01" @default.
- W2134031196 modified "2023-10-09" @default.
- W2134031196 title "Increasing the hydrophobic interaction between terminal W-motifs enhances the stability of Salmonella typhimurium sialidase. A general strategy for the stabilization of β-propeller protein fold" @default.
- W2134031196 cites W1588329959 @default.
- W2134031196 cites W1969995117 @default.
- W2134031196 cites W1976767025 @default.
- W2134031196 cites W1984198411 @default.
- W2134031196 cites W1995352629 @default.
- W2134031196 cites W1998707947 @default.
- W2134031196 cites W2006933779 @default.
- W2134031196 cites W2013504852 @default.
- W2134031196 cites W2020365928 @default.
- W2134031196 cites W2026258231 @default.
- W2134031196 cites W2027009946 @default.
- W2134031196 cites W2030390780 @default.
- W2134031196 cites W2052280808 @default.
- W2134031196 cites W2071138716 @default.
- W2134031196 cites W2100564865 @default.
- W2134031196 cites W2112862159 @default.
- W2134031196 cites W2125294668 @default.
- W2134031196 cites W2125717174 @default.
- W2134031196 cites W2136906322 @default.
- W2134031196 cites W2163268673 @default.
- W2134031196 cites W2163895770 @default.
- W2134031196 doi "https://doi.org/10.1093/protein/14.11.891" @default.
- W2134031196 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11742108" @default.
- W2134031196 hasPublicationYear "2001" @default.
- W2134031196 type Work @default.
- W2134031196 sameAs 2134031196 @default.
- W2134031196 citedByCount "9" @default.
- W2134031196 countsByYear W21340311962015 @default.
- W2134031196 countsByYear W21340311962016 @default.
- W2134031196 crossrefType "journal-article" @default.
- W2134031196 hasAuthorship W2134031196A5013641148 @default.
- W2134031196 hasAuthorship W2134031196A5029088690 @default.
- W2134031196 hasBestOaLocation W21340311961 @default.
- W2134031196 hasConcept C104317684 @default.
- W2134031196 hasConcept C11804247 @default.
- W2134031196 hasConcept C143065580 @default.
- W2134031196 hasConcept C147816474 @default.
- W2134031196 hasConcept C181199279 @default.
- W2134031196 hasConcept C185592680 @default.
- W2134031196 hasConcept C2779463914 @default.
- W2134031196 hasConcept C2781065037 @default.
- W2134031196 hasConcept C523546767 @default.
- W2134031196 hasConcept C54355233 @default.
- W2134031196 hasConcept C55493867 @default.
- W2134031196 hasConcept C86803240 @default.
- W2134031196 hasConcept C90260826 @default.
- W2134031196 hasConceptScore W2134031196C104317684 @default.
- W2134031196 hasConceptScore W2134031196C11804247 @default.
- W2134031196 hasConceptScore W2134031196C143065580 @default.
- W2134031196 hasConceptScore W2134031196C147816474 @default.
- W2134031196 hasConceptScore W2134031196C181199279 @default.
- W2134031196 hasConceptScore W2134031196C185592680 @default.
- W2134031196 hasConceptScore W2134031196C2779463914 @default.
- W2134031196 hasConceptScore W2134031196C2781065037 @default.
- W2134031196 hasConceptScore W2134031196C523546767 @default.
- W2134031196 hasConceptScore W2134031196C54355233 @default.
- W2134031196 hasConceptScore W2134031196C55493867 @default.
- W2134031196 hasConceptScore W2134031196C86803240 @default.
- W2134031196 hasConceptScore W2134031196C90260826 @default.
- W2134031196 hasIssue "11" @default.
- W2134031196 hasLocation W21340311961 @default.
- W2134031196 hasLocation W21340311962 @default.
- W2134031196 hasOpenAccess W2134031196 @default.
- W2134031196 hasPrimaryLocation W21340311961 @default.
- W2134031196 hasRelatedWork W1990659752 @default.
- W2134031196 hasRelatedWork W1998793182 @default.
- W2134031196 hasRelatedWork W2132182152 @default.
- W2134031196 hasRelatedWork W2139575802 @default.
- W2134031196 hasRelatedWork W2326910020 @default.
- W2134031196 hasRelatedWork W2356986014 @default.
- W2134031196 hasRelatedWork W2419373478 @default.
- W2134031196 hasRelatedWork W2608959436 @default.
- W2134031196 hasRelatedWork W3126804609 @default.
- W2134031196 hasRelatedWork W4286855210 @default.
- W2134031196 hasVolume "14" @default.
- W2134031196 isParatext "false" @default.
- W2134031196 isRetracted "false" @default.
- W2134031196 magId "2134031196" @default.
- W2134031196 workType "article" @default.