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• W2134041885 abstract "There is controversy regarding a potential increased risk of lymphoma in patients with atopic dermatitis (AD).To assess the risk of lymphoma and the role of topical treatments in patients with AD.A systematic literature search and a separate meta-analysis were performed on case control and cohort studies.Of the 3979 articles retrieved, 24 references met the inclusion criteria. In cohort studies, the risk of lymphoma was slightly increased, with a relative risk (RR) of 1.43 (95% confidence interval [CI], 1.12-1.81). In case control studies, no significant increased risk of lymphoma was found, with an odds ratio (OR) of 1.18 (95% CI, 0.94-1.47). Severity of AD was a significant risk factor. Highly potent topical steroids were associated with an increased risk of lymphoma. For topical calcineurin inhibitors (TCIs), a significant association between tacrolimus and mostly skin lymphoma was found in 1 study.Confusion between severe AD and cutaneous T-cell lymphoma may account for part of the increased risk of lymphoma in patients with AD.This systematic literature review shows a slightly increased risk of lymphoma in patients with AD. Severity of AD appears to be a significant risk factor. The role of topical steroids and TCIs is unlikely to be significant." @default.
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• W2134041885 date "2015-06-01" @default.
• W2134041885 modified "2023-10-16" @default.
• W2134041885 title "Risk of lymphoma in patients with atopic dermatitis and the role of topical treatment: A systematic review and meta-analysis" @default.
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• W2134041885 doi "https://doi.org/10.1016/j.jaad.2015.02.1116" @default.
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