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- W2134072971 abstract "The ketogenic diet and its newer variants are clinically useful in treating epilepsy. They can also have antiepileptogenic properties and can eventually have a role in treating other neurologic and nonneurologic conditions. Despite being nearly a century old, identifying the molecular underpinnings of the ketogenic diet has been challenging. However, recent studies provide experimental evidence for 4 distinct mechanisms that could contribute to the antiseizure and other beneficial effects of these diets. These mechanisms include carbohydrate reduction, activation of adenosine triphosphate (ATP)-sensitive potassium channels by mitochondrial metabolism, inhibition of the mammalian target of rapamycin pathway, and inhibition of glutamatergic excitatory synaptic transmission." @default.
- W2134072971 created "2016-06-24" @default.
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- W2134072971 date "2013-05-13" @default.
- W2134072971 modified "2023-10-01" @default.
- W2134072971 title "How Does the Ketogenic Diet Work? Four Potential Mechanisms" @default.
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- W2134072971 doi "https://doi.org/10.1177/0883073813487598" @default.
- W2134072971 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3971996" @default.
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