Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134076892> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2134076892 endingPage "204" @default.
- W2134076892 startingPage "201" @default.
- W2134076892 abstract "A broad spectrum caspase inhibitor reduces hypoxic ischemic brain injury. We hypothesized that a specific caspase-9 inhibitor would provide similar protection. Seven-day-old rat pups had the right carotid artery ligated, then were subjected to 2.5 h of 8% oxygen. Caspase-9 activity in the right cortex was measured enzymatically. Caspase-9 activity was increased at 6, 12, and 24 h after injury. LEHD-CHO is a specific cell permeable caspase-9 inhibitor. LEHD-CHO given intracerebroventricularly (i.c.v.) into the brain after the hypoxic period eliminated the increase in caspase-9 activity. The greatest effect was at a dose of 50 microg/pup (1.6 micromol/kg). Fifty-two pups were randomly assigned to receive 50 microg/pup of i.c.v. LEHD-CHO or vehicle immediately after the hypoxic period. The loss of cortical neurons in the right hemisphere 22 days after injury was 52.0+/-8% in the vehicle treated animals, and 25+/-9% in the LEHD-CHO treated animals (P<0.05). Inhibiting caspase-9 activity reduces loss of neurons after brain injury." @default.
- W2134076892 created "2016-06-24" @default.
- W2134076892 creator A5003872298 @default.
- W2134076892 creator A5075733194 @default.
- W2134076892 creator A5077684366 @default.
- W2134076892 date "2003-07-01" @default.
- W2134076892 modified "2023-09-27" @default.
- W2134076892 title "Inhibiting caspase-9 after injury reduces hypoxic ischemic neuronal injury in the cortex in the newborn rat" @default.
- W2134076892 cites W1974172653 @default.
- W2134076892 cites W2004568898 @default.
- W2134076892 cites W2034135331 @default.
- W2134076892 cites W2058889292 @default.
- W2134076892 cites W2072847038 @default.
- W2134076892 cites W2075255898 @default.
- W2134076892 cites W2087971085 @default.
- W2134076892 cites W2090673332 @default.
- W2134076892 cites W2136967026 @default.
- W2134076892 cites W2411726279 @default.
- W2134076892 cites W4236487956 @default.
- W2134076892 cites W43210285 @default.
- W2134076892 doi "https://doi.org/10.1016/s0304-3940(03)00466-x" @default.
- W2134076892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12812840" @default.
- W2134076892 hasPublicationYear "2003" @default.
- W2134076892 type Work @default.
- W2134076892 sameAs 2134076892 @default.
- W2134076892 citedByCount "22" @default.
- W2134076892 countsByYear W21340768922012 @default.
- W2134076892 countsByYear W21340768922019 @default.
- W2134076892 countsByYear W21340768922022 @default.
- W2134076892 crossrefType "journal-article" @default.
- W2134076892 hasAuthorship W2134076892A5003872298 @default.
- W2134076892 hasAuthorship W2134076892A5075733194 @default.
- W2134076892 hasAuthorship W2134076892A5077684366 @default.
- W2134076892 hasConcept C12519072 @default.
- W2134076892 hasConcept C126322002 @default.
- W2134076892 hasConcept C134018914 @default.
- W2134076892 hasConcept C185592680 @default.
- W2134076892 hasConcept C190283241 @default.
- W2134076892 hasConcept C2781064879 @default.
- W2134076892 hasConcept C2987047532 @default.
- W2134076892 hasConcept C31573885 @default.
- W2134076892 hasConcept C42219234 @default.
- W2134076892 hasConcept C55493867 @default.
- W2134076892 hasConcept C71924100 @default.
- W2134076892 hasConcept C98274493 @default.
- W2134076892 hasConcept C98424977 @default.
- W2134076892 hasConceptScore W2134076892C12519072 @default.
- W2134076892 hasConceptScore W2134076892C126322002 @default.
- W2134076892 hasConceptScore W2134076892C134018914 @default.
- W2134076892 hasConceptScore W2134076892C185592680 @default.
- W2134076892 hasConceptScore W2134076892C190283241 @default.
- W2134076892 hasConceptScore W2134076892C2781064879 @default.
- W2134076892 hasConceptScore W2134076892C2987047532 @default.
- W2134076892 hasConceptScore W2134076892C31573885 @default.
- W2134076892 hasConceptScore W2134076892C42219234 @default.
- W2134076892 hasConceptScore W2134076892C55493867 @default.
- W2134076892 hasConceptScore W2134076892C71924100 @default.
- W2134076892 hasConceptScore W2134076892C98274493 @default.
- W2134076892 hasConceptScore W2134076892C98424977 @default.
- W2134076892 hasIssue "3" @default.
- W2134076892 hasLocation W21340768921 @default.
- W2134076892 hasLocation W21340768922 @default.
- W2134076892 hasOpenAccess W2134076892 @default.
- W2134076892 hasPrimaryLocation W21340768921 @default.
- W2134076892 hasRelatedWork W1977139249 @default.
- W2134076892 hasRelatedWork W1980109110 @default.
- W2134076892 hasRelatedWork W1995713671 @default.
- W2134076892 hasRelatedWork W2043846492 @default.
- W2134076892 hasRelatedWork W2152442751 @default.
- W2134076892 hasRelatedWork W2355416043 @default.
- W2134076892 hasRelatedWork W2359087903 @default.
- W2134076892 hasRelatedWork W2487472729 @default.
- W2134076892 hasRelatedWork W2563843266 @default.
- W2134076892 hasRelatedWork W2748952813 @default.
- W2134076892 hasVolume "344" @default.
- W2134076892 isParatext "false" @default.
- W2134076892 isRetracted "false" @default.
- W2134076892 magId "2134076892" @default.
- W2134076892 workType "article" @default.