FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134097600> ?p ?o ?g. }

• W2134097600 endingPage "226" @default.
• W2134097600 startingPage "214" @default.
• W2134097600 abstract "ABSTRACT Intravenous drug addiction is known to be associated with an inordinate morbidity and mortality. As our previous report had identified an immune phenotype consistent with accelerated ageing, we wished to investigate how much of this change may have been related to chronic viral hepatitis. A total of 12 409 clinical pathology results from the period 1995–2007 were reviewed. To control for the differences in age, only patients less than 48 years of age were considered. A total of 636 substance use disorder (SUD) and 6103 non‐SUD (N‐SUD) patients were studied. They had comparable ages (mean ± SD 31.32 ± 6.90 versus 31.57 ± 9.23, P ‐value not significant), but the SUD group had more males (74.37% versus 53.20%, P < 0.001). For most of the changes examined splitting the two SUD groups into hepatitis C positive (HCV+) and hepatitis C negative (HCV−) demonstrated that the majority of the described changes were most marked in the HCV+ group. The globulins were higher in the HCV+ group and the albumin was lower and fell more markedly with age than in N‐SUD or HCV− (all P < 0.001). The globulin/albumin ratio was significantly higher in HCV+ than HCV− or N‐SUD (both P < 0.0001) and rose more with age. These changes were paralleled by the ESR, elevations in the CRP and lymphocyte count. Transaminases were elevated in SUD and HCV+ groups compared with N‐SUD (all P < 0.02). At multivariate analysis ESR, lymphocyte count, dual hepatitis B and C seropositivity, AST and HCVAb were significant predictors of the serum globulin level and accounted for 21% of the variance. These data extend our earlier report and show that much of the immunosenescent phenotype of SUD, encompassing the known immunosuppression and the observed immunostimulation, is statistically related to chronic viral hepatitis. Important theoretical and practical management (vaccination) implications ensue." @default.
• W2134097600 created "2016-06-24" @default.
• W2134097600 creator A5082376941 @default.
• W2134097600 date "2009-03-05" @default.
• W2134097600 modified "2023-10-10" @default.
• W2134097600 title "Chronic viral hepatitis is a significant contributor to the immunosenescent phenotype of parenteral drug addiction" @default.
• W2134097600 cites W1509651230 @default.
• W2134097600 cites W1536144403 @default.
• W2134097600 cites W1546769430 @default.
• W2134097600 cites W1972098762 @default.
• W2134097600 cites W1981368806 @default.
• W2134097600 cites W1981947814 @default.
• W2134097600 cites W1982088059 @default.
• W2134097600 cites W1985423778 @default.
• W2134097600 cites W1987631879 @default.
• W2134097600 cites W1990826584 @default.
• W2134097600 cites W1991489334 @default.
• W2134097600 cites W1999387878 @default.
• W2134097600 cites W2001536268 @default.
• W2134097600 cites W2002969023 @default.
• W2134097600 cites W2003356209 @default.
• W2134097600 cites W2009494912 @default.
• W2134097600 cites W2015565638 @default.
• W2134097600 cites W2018300031 @default.
• W2134097600 cites W2018365780 @default.
• W2134097600 cites W2020371789 @default.
• W2134097600 cites W2026101939 @default.
• W2134097600 cites W2026180657 @default.
• W2134097600 cites W2029358527 @default.
• W2134097600 cites W2034310547 @default.
• W2134097600 cites W2041368098 @default.
• W2134097600 cites W2044193462 @default.
• W2134097600 cites W2049018645 @default.
• W2134097600 cites W2058709767 @default.
• W2134097600 cites W2059864370 @default.
• W2134097600 cites W2064342046 @default.
• W2134097600 cites W2065996123 @default.
• W2134097600 cites W2066892097 @default.
• W2134097600 cites W2076463185 @default.
• W2134097600 cites W2078585226 @default.
• W2134097600 cites W2082402714 @default.
• W2134097600 cites W2084237578 @default.
• W2134097600 cites W2085767270 @default.
• W2134097600 cites W2091273397 @default.
• W2134097600 cites W2092881530 @default.
• W2134097600 cites W2096059629 @default.
• W2134097600 cites W2103338170 @default.
• W2134097600 cites W2112122296 @default.
• W2134097600 cites W2112781452 @default.
• W2134097600 cites W2115473812 @default.
• W2134097600 cites W2118740249 @default.
• W2134097600 cites W2119025201 @default.
• W2134097600 cites W2131605289 @default.
• W2134097600 cites W2147126871 @default.
• W2134097600 cites W2151428930 @default.
• W2134097600 cites W2153840275 @default.
• W2134097600 cites W2157886160 @default.
• W2134097600 cites W2161265633 @default.
• W2134097600 cites W2166490118 @default.
• W2134097600 cites W2166704790 @default.
• W2134097600 cites W2167590969 @default.
• W2134097600 cites W2168242208 @default.
• W2134097600 cites W4236078445 @default.
• W2134097600 doi "https://doi.org/10.1111/j.1369-1600.2008.00123.x" @default.
• W2134097600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18811680" @default.
• W2134097600 hasPublicationYear "2009" @default.
• W2134097600 type Work @default.
• W2134097600 sameAs 2134097600 @default.
• W2134097600 citedByCount "10" @default.
• W2134097600 countsByYear W21340976002012 @default.
• W2134097600 countsByYear W21340976002017 @default.
• W2134097600 countsByYear W21340976002018 @default.
• W2134097600 countsByYear W21340976002021 @default.
• W2134097600 crossrefType "journal-article" @default.
• W2134097600 hasAuthorship W2134097600A5082376941 @default.
• W2134097600 hasBestOaLocation W21340976001 @default.
• W2134097600 hasConcept C118552586 @default.
• W2134097600 hasConcept C126322002 @default.
• W2134097600 hasConcept C203014093 @default.
• W2134097600 hasConcept C2522874641 @default.
• W2134097600 hasConcept C2776029263 @default.
• W2134097600 hasConcept C2776408679 @default.
• W2134097600 hasConcept C2776455275 @default.
• W2134097600 hasConcept C2777761686 @default.
• W2134097600 hasConcept C40010229 @default.
• W2134097600 hasConcept C48856860 @default.
• W2134097600 hasConcept C71924100 @default.
• W2134097600 hasConcept C81358767 @default.
• W2134097600 hasConcept C90924648 @default.
• W2134097600 hasConceptScore W2134097600C118552586 @default.
• W2134097600 hasConceptScore W2134097600C126322002 @default.
• W2134097600 hasConceptScore W2134097600C203014093 @default.
• W2134097600 hasConceptScore W2134097600C2522874641 @default.
• W2134097600 hasConceptScore W2134097600C2776029263 @default.
• W2134097600 hasConceptScore W2134097600C2776408679 @default.
• W2134097600 hasConceptScore W2134097600C2776455275 @default.
• W2134097600 hasConceptScore W2134097600C2777761686 @default.
• W2134097600 hasConceptScore W2134097600C40010229 @default.

• next