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- W2134138329 abstract "Gene targeting was used to produce mice deficient in intercellular adhesion molecule 1 (ICAM-1) or CD54, an immunoglobulin-like cell adhesion molecule that binds beta 2 integrins. Homozygous deficient animals develop normally, are fertile, and have a moderate granulocytosis. The nature of the mutation, RNA analysis, and immunostaining are consistent with complete loss of surface expression of ICAM-1. Deficient mice exhibit prominent abnormalities of inflammatory responses including impaired neutrophil emigration in response to chemical peritonitis and decreased contact hypersensitivity to 2,4-dinitrofluorobenzene. Mutant cells provided negligible stimulation in the mixed lymphocyte reaction, although they proliferated normally as responder cells. These mutant animals will be extremely valuable for examining the role of ICAM-1 and its counterreceptors in inflammatory disease processes and atherosclerosis." @default.
- W2134138329 created "2016-06-24" @default.
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- W2134138329 date "1993-09-15" @default.
- W2134138329 modified "2023-10-17" @default.
- W2134138329 title "Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1." @default.
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- W2134138329 doi "https://doi.org/10.1073/pnas.90.18.8529" @default.
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