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- W2134143236 abstract "β-Diguetoxin-Dc1a (Dc1a) is a toxin from the desert bush spider Diguetia canities that incapacitates insects at concentrations that are non-toxic to mammals. Dc1a promotes opening of German cockroach voltage-gated sodium (Nav) channels (BgNav1), whereas human Nav channels are insensitive. Here, by transplanting commonly targeted S3b-S4 paddle motifs within BgNav1 voltage sensors into Kv2.1, we find that Dc1a interacts with the domain II voltage sensor. In contrast, Dc1a has little effect on sodium currents mediated by PaNav1 channels from the American cockroach even though their domain II paddle motifs are identical. When exploring regions responsible for PaNav1 resistance to Dc1a, we identified two residues within the BgNav1 domain II S1-S2 loop that when mutated to their PaNav1 counterparts drastically reduce toxin susceptibility. Overall, our results reveal a distinct region within insect Nav channels that helps determine Dc1a sensitivity, a concept that will be valuable for the design of insect-selective insecticides." @default.
- W2134143236 created "2016-06-24" @default.
- W2134143236 creator A5005178664 @default.
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- W2134143236 date "2014-07-11" @default.
- W2134143236 modified "2023-10-14" @default.
- W2134143236 title "A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a" @default.
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- W2134143236 cites W1970718997 @default.
- W2134143236 cites W1970796358 @default.
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- W2134143236 cites W2000054304 @default.
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- W2134143236 cites W2002527974 @default.
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- W2134143236 cites W2007907068 @default.
- W2134143236 cites W2013765116 @default.
- W2134143236 cites W2015664193 @default.
- W2134143236 cites W2016068689 @default.
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- W2134143236 cites W2045629573 @default.
- W2134143236 cites W2046364225 @default.
- W2134143236 cites W2047433025 @default.
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- W2134143236 cites W2053039841 @default.
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- W2134143236 doi "https://doi.org/10.1038/ncomms5350" @default.
- W2134143236 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4115291" @default.
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- W2134143236 hasPublicationYear "2014" @default.
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