Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134156907> ?p ?o ?g. }
- W2134156907 abstract "The ubiquitin-proteasome and autophagy-lysosome pathways are the two major routes of protein and organelle clearance. The role of the proteasome pathway in mammalian muscle has not been examined in vivo. In this study, we report that the muscle-specific deletion of a crucial proteasomal gene, Rpt3, resulted in profound muscle growth defects and a decrease in force production in mice. Specifically, developing muscles in conditional Rpt3-knockout animals showed dysregulated proteasomal activity. The autophagy pathway was upregulated, but the process of autophagosome formation was impaired. A microscopic analysis revealed the accumulation of basophilic inclusions and disorganization of the sarcomeres in young adult mice. Our results suggest that appropriate proteasomal activity is important for muscle growth and for maintaining myofiber integrity in collaboration with autophagy pathways. The deletion of a component of the proteasome complex contributed to myofiber degeneration and weakness in muscle disorders that are characterized by the accumulation of abnormal inclusions." @default.
- W2134156907 created "2016-06-24" @default.
- W2134156907 creator A5028146410 @default.
- W2134156907 creator A5028839003 @default.
- W2134156907 creator A5028898683 @default.
- W2134156907 creator A5042826860 @default.
- W2134156907 creator A5053778844 @default.
- W2134156907 creator A5061304175 @default.
- W2134156907 creator A5061509682 @default.
- W2134156907 creator A5062628353 @default.
- W2134156907 creator A5062883848 @default.
- W2134156907 creator A5066941256 @default.
- W2134156907 creator A5069055172 @default.
- W2134156907 creator A5073117349 @default.
- W2134156907 creator A5076017842 @default.
- W2134156907 creator A5077794725 @default.
- W2134156907 creator A5080721839 @default.
- W2134156907 creator A5090377816 @default.
- W2134156907 date "2014-01-01" @default.
- W2134156907 modified "2023-10-16" @default.
- W2134156907 title "Proteasome dysfunction induces muscle growth defects and protein aggregation" @default.
- W2134156907 cites W1509912990 @default.
- W2134156907 cites W1523693806 @default.
- W2134156907 cites W1528922106 @default.
- W2134156907 cites W1558226015 @default.
- W2134156907 cites W1965470471 @default.
- W2134156907 cites W1965609474 @default.
- W2134156907 cites W1966524514 @default.
- W2134156907 cites W1970110195 @default.
- W2134156907 cites W1971857747 @default.
- W2134156907 cites W1972597570 @default.
- W2134156907 cites W1973963032 @default.
- W2134156907 cites W1977946208 @default.
- W2134156907 cites W1978668631 @default.
- W2134156907 cites W1979007603 @default.
- W2134156907 cites W1985534077 @default.
- W2134156907 cites W1987807233 @default.
- W2134156907 cites W1993741004 @default.
- W2134156907 cites W2011640487 @default.
- W2134156907 cites W2021598579 @default.
- W2134156907 cites W2024946243 @default.
- W2134156907 cites W2025665129 @default.
- W2134156907 cites W2028450839 @default.
- W2134156907 cites W2033797333 @default.
- W2134156907 cites W2035088786 @default.
- W2134156907 cites W2036787961 @default.
- W2134156907 cites W2043251964 @default.
- W2134156907 cites W2044961049 @default.
- W2134156907 cites W2056607803 @default.
- W2134156907 cites W2062922078 @default.
- W2134156907 cites W2063043143 @default.
- W2134156907 cites W2074911710 @default.
- W2134156907 cites W2075197751 @default.
- W2134156907 cites W2077863341 @default.
- W2134156907 cites W2078192607 @default.
- W2134156907 cites W2082442359 @default.
- W2134156907 cites W2088821814 @default.
- W2134156907 cites W2094014129 @default.
- W2134156907 cites W2106554287 @default.
- W2134156907 cites W2109714653 @default.
- W2134156907 cites W2109716633 @default.
- W2134156907 cites W2119399459 @default.
- W2134156907 cites W2126937565 @default.
- W2134156907 cites W2128677681 @default.
- W2134156907 cites W2132524516 @default.
- W2134156907 cites W2136000647 @default.
- W2134156907 cites W2136187443 @default.
- W2134156907 cites W2139772062 @default.
- W2134156907 cites W2141424523 @default.
- W2134156907 cites W2144385565 @default.
- W2134156907 cites W2159796957 @default.
- W2134156907 cites W2161158602 @default.
- W2134156907 cites W2167512318 @default.
- W2134156907 cites W2169448756 @default.
- W2134156907 cites W2602035017 @default.
- W2134156907 doi "https://doi.org/10.1242/jcs.150961" @default.
- W2134156907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4265737" @default.
- W2134156907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25380823" @default.
- W2134156907 hasPublicationYear "2014" @default.
- W2134156907 type Work @default.
- W2134156907 sameAs 2134156907 @default.
- W2134156907 citedByCount "49" @default.
- W2134156907 countsByYear W21341569072015 @default.
- W2134156907 countsByYear W21341569072016 @default.
- W2134156907 countsByYear W21341569072017 @default.
- W2134156907 countsByYear W21341569072018 @default.
- W2134156907 countsByYear W21341569072019 @default.
- W2134156907 countsByYear W21341569072020 @default.
- W2134156907 countsByYear W21341569072021 @default.
- W2134156907 countsByYear W21341569072022 @default.
- W2134156907 countsByYear W21341569072023 @default.
- W2134156907 crossrefType "journal-article" @default.
- W2134156907 hasAuthorship W2134156907A5028146410 @default.
- W2134156907 hasAuthorship W2134156907A5028839003 @default.
- W2134156907 hasAuthorship W2134156907A5028898683 @default.
- W2134156907 hasAuthorship W2134156907A5042826860 @default.
- W2134156907 hasAuthorship W2134156907A5053778844 @default.
- W2134156907 hasAuthorship W2134156907A5061304175 @default.
- W2134156907 hasAuthorship W2134156907A5061509682 @default.
- W2134156907 hasAuthorship W2134156907A5062628353 @default.