FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134157025> ?p ?o ?g. }

• W2134157025 abstract "Single-molecule experiments on polymeric DNA show that the molecule can be overstretched at nearly constant force by about 70% beyond its relaxed contour length. In this publication we use steered molecular dynamics (MD) simulation to study the effect of structural defects on force-extension curves and structures at high elongation in a 30 base pair duplex pulled by its torsionally unconstrained 5' -5' ends. The defect-free duplex shows a plateau in the force-extension curve at 120 pN in which large segments with inclined and paired bases (S-DNA) near both ends of the duplex coexist with a central B-type segment separated from the former by small denaturation bubbles. In the presence of a base mismatch or a nick, force-extension curves are very similar to the ones of the defect-free duplex. For the duplex with a base mismatch, S-type segments with highly inclined base pairs are not observed; rather, the overstretched duplex consists of B-type segments separated by denaturation bubbles. The nicked duplex evolves, via a two-step transition, into a two-domain structure characterized by a large S-type segment coexisting with several short S-type segments which are separated by short denaturation bubbles. Our results suggest that in the presence of nicks the force-extension curve of highly elongated duplex DNA might reflect locally highly inhomogeneous stretching." @default.
• W2134157025 created "2016-06-24" @default.
• W2134157025 creator A5054435430 @default.
• W2134157025 creator A5065859286 @default.
• W2134157025 date "2009-10-22" @default.
• W2134157025 modified "2023-10-14" @default.
• W2134157025 title "Overstretching of a 30 bp DNA duplex studied with steered molecular dynamics simulation: Effects of structural defects on structure and force-extension relation" @default.
• W2134157025 cites W1607200676 @default.
• W2134157025 cites W1969971166 @default.
• W2134157025 cites W1977246752 @default.
• W2134157025 cites W1980722147 @default.
• W2134157025 cites W1981742364 @default.
• W2134157025 cites W1987542305 @default.
• W2134157025 cites W1993581676 @default.
• W2134157025 cites W1996756349 @default.
• W2134157025 cites W1998196091 @default.
• W2134157025 cites W2011120754 @default.
• W2134157025 cites W2032289589 @default.
• W2134157025 cites W2035236521 @default.
• W2134157025 cites W2038532826 @default.
• W2134157025 cites W2041241290 @default.
• W2134157025 cites W2047961001 @default.
• W2134157025 cites W2062061353 @default.
• W2134157025 cites W2068386280 @default.
• W2134157025 cites W2069123478 @default.
• W2134157025 cites W2081407528 @default.
• W2134157025 cites W2082753131 @default.
• W2134157025 cites W2108242211 @default.
• W2134157025 cites W2116934953 @default.
• W2134157025 cites W2120110930 @default.
• W2134157025 cites W2136729627 @default.
• W2134157025 cites W2144631354 @default.
• W2134157025 cites W2149302226 @default.
• W2134157025 cites W2159777706 @default.
• W2134157025 cites W2171268876 @default.
• W2134157025 doi "https://doi.org/10.1140/epje/i2009-10524-5" @default.
• W2134157025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19847465" @default.
• W2134157025 hasPublicationYear "2009" @default.
• W2134157025 type Work @default.
• W2134157025 sameAs 2134157025 @default.
• W2134157025 citedByCount "16" @default.
• W2134157025 countsByYear W21341570252013 @default.
• W2134157025 countsByYear W21341570252014 @default.
• W2134157025 countsByYear W21341570252016 @default.
• W2134157025 countsByYear W21341570252017 @default.
• W2134157025 countsByYear W21341570252019 @default.
• W2134157025 countsByYear W21341570252020 @default.
• W2134157025 countsByYear W21341570252022 @default.
• W2134157025 countsByYear W21341570252023 @default.
• W2134157025 crossrefType "journal-article" @default.
• W2134157025 hasAuthorship W2134157025A5054435430 @default.
• W2134157025 hasAuthorship W2134157025A5065859286 @default.
• W2134157025 hasBestOaLocation W21341570252 @default.
• W2134157025 hasConcept C112950240 @default.
• W2134157025 hasConcept C12554922 @default.
• W2134157025 hasConcept C13965031 @default.
• W2134157025 hasConcept C147597530 @default.
• W2134157025 hasConcept C159467904 @default.
• W2134157025 hasConcept C159985019 @default.
• W2134157025 hasConcept C185581394 @default.
• W2134157025 hasConcept C185592680 @default.
• W2134157025 hasConcept C192562407 @default.
• W2134157025 hasConcept C2776923230 @default.
• W2134157025 hasConcept C33947775 @default.
• W2134157025 hasConcept C552990157 @default.
• W2134157025 hasConcept C55493867 @default.
• W2134157025 hasConcept C59593255 @default.
• W2134157025 hasConcept C8010536 @default.
• W2134157025 hasConcept C86803240 @default.
• W2134157025 hasConcept C99611785 @default.
• W2134157025 hasConceptScore W2134157025C112950240 @default.
• W2134157025 hasConceptScore W2134157025C12554922 @default.
• W2134157025 hasConceptScore W2134157025C13965031 @default.
• W2134157025 hasConceptScore W2134157025C147597530 @default.
• W2134157025 hasConceptScore W2134157025C159467904 @default.
• W2134157025 hasConceptScore W2134157025C159985019 @default.
• W2134157025 hasConceptScore W2134157025C185581394 @default.
• W2134157025 hasConceptScore W2134157025C185592680 @default.
• W2134157025 hasConceptScore W2134157025C192562407 @default.
• W2134157025 hasConceptScore W2134157025C2776923230 @default.
• W2134157025 hasConceptScore W2134157025C33947775 @default.
• W2134157025 hasConceptScore W2134157025C552990157 @default.
• W2134157025 hasConceptScore W2134157025C55493867 @default.
• W2134157025 hasConceptScore W2134157025C59593255 @default.
• W2134157025 hasConceptScore W2134157025C8010536 @default.
• W2134157025 hasConceptScore W2134157025C86803240 @default.
• W2134157025 hasConceptScore W2134157025C99611785 @default.
• W2134157025 hasIssue "3" @default.
• W2134157025 hasLocation W21341570251 @default.
• W2134157025 hasLocation W21341570252 @default.
• W2134157025 hasLocation W21341570253 @default.
• W2134157025 hasOpenAccess W2134157025 @default.
• W2134157025 hasPrimaryLocation W21341570251 @default.
• W2134157025 hasRelatedWork W1995372961 @default.
• W2134157025 hasRelatedWork W2008718114 @default.
• W2134157025 hasRelatedWork W2014555734 @default.
• W2134157025 hasRelatedWork W2041863280 @default.
• W2134157025 hasRelatedWork W2071099229 @default.
• W2134157025 hasRelatedWork W2090615979 @default.
• W2134157025 hasRelatedWork W2097784309 @default.

• next