Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134160513> ?p ?o ?g. }
- W2134160513 endingPage "273" @default.
- W2134160513 startingPage "266" @default.
- W2134160513 abstract "Oxidative stress is now recognized as a major predisposing factor in the pathogenesis of COPD. Existing therapies for COPD are ineffective at halting disease progression, with bronchodilators being the mainstay of pharmacotherapy, providing symptomatic relief only. It is, therefore, important for a better understanding of the underlying mechanisms by which oxidative stress drives disease pathogenesis to develop novel and more effective therapies. Antioxidant capacity in COPD is substantially reduced as a result of cigarette smoking and exacerbations, with oxidative stress persisting long after the cessation of cigarette smoking or exacerbation, due to the continued production of reactive oxygen species from endogenous sources. We discuss (1) how oxidative stress arises in the lung, (2) how it is neutralized, (3) what genetic factors may predispose to the development of COPD, and (4) how this impacts inflammation and autoimmunity in the development of emphysema and small airways disease. Finally, various strategies have been considered to neutralize the increased oxidative burden present in COPD. This review highlights why current antioxidant strategies have so far failed and what promising alternatives are on the horizon. Moreover, a number of studies have shown that there is no single magic bullet to combat oxidative stress, but instead a combination therapy, targeting oxidative stress in the various subcellular compartments, may prove to be more effective in COPD." @default.
- W2134160513 created "2016-06-24" @default.
- W2134160513 creator A5011492305 @default.
- W2134160513 creator A5030258071 @default.
- W2134160513 date "2013-07-01" @default.
- W2134160513 modified "2023-10-16" @default.
- W2134160513 title "Oxidative Stress in COPD" @default.
- W2134160513 cites W1517798087 @default.
- W2134160513 cites W1560738700 @default.
- W2134160513 cites W1909558445 @default.
- W2134160513 cites W1941094264 @default.
- W2134160513 cites W1965865448 @default.
- W2134160513 cites W1968668179 @default.
- W2134160513 cites W1972495472 @default.
- W2134160513 cites W1975228172 @default.
- W2134160513 cites W1977273234 @default.
- W2134160513 cites W1980244548 @default.
- W2134160513 cites W1985002063 @default.
- W2134160513 cites W1985122732 @default.
- W2134160513 cites W1989700731 @default.
- W2134160513 cites W1990646040 @default.
- W2134160513 cites W2010511107 @default.
- W2134160513 cites W2015867310 @default.
- W2134160513 cites W2025222765 @default.
- W2134160513 cites W2029196664 @default.
- W2134160513 cites W2032347563 @default.
- W2134160513 cites W2035078285 @default.
- W2134160513 cites W2037064225 @default.
- W2134160513 cites W2039640602 @default.
- W2134160513 cites W2040499888 @default.
- W2134160513 cites W2040821832 @default.
- W2134160513 cites W2041056515 @default.
- W2134160513 cites W2043250256 @default.
- W2134160513 cites W2043811030 @default.
- W2134160513 cites W2043954494 @default.
- W2134160513 cites W2044433987 @default.
- W2134160513 cites W2045749557 @default.
- W2134160513 cites W2049587500 @default.
- W2134160513 cites W2051806959 @default.
- W2134160513 cites W2052211411 @default.
- W2134160513 cites W2052567913 @default.
- W2134160513 cites W2053517795 @default.
- W2134160513 cites W2063106464 @default.
- W2134160513 cites W2063761001 @default.
- W2134160513 cites W2069582801 @default.
- W2134160513 cites W2070580570 @default.
- W2134160513 cites W2077811143 @default.
- W2134160513 cites W2083493283 @default.
- W2134160513 cites W2086779725 @default.
- W2134160513 cites W2087861952 @default.
- W2134160513 cites W2089097264 @default.
- W2134160513 cites W2100995455 @default.
- W2134160513 cites W2101773788 @default.
- W2134160513 cites W2105408775 @default.
- W2134160513 cites W2105843214 @default.
- W2134160513 cites W2108983987 @default.
- W2134160513 cites W2116125235 @default.
- W2134160513 cites W2117560139 @default.
- W2134160513 cites W2117975450 @default.
- W2134160513 cites W2123266507 @default.
- W2134160513 cites W2127938597 @default.
- W2134160513 cites W2128399547 @default.
- W2134160513 cites W2131241278 @default.
- W2134160513 cites W2131436543 @default.
- W2134160513 cites W2131437805 @default.
- W2134160513 cites W2134106278 @default.
- W2134160513 cites W2134724878 @default.
- W2134160513 cites W2136123560 @default.
- W2134160513 cites W2137200414 @default.
- W2134160513 cites W2138537778 @default.
- W2134160513 cites W2139909190 @default.
- W2134160513 cites W2141055635 @default.
- W2134160513 cites W2143786412 @default.
- W2134160513 cites W2144266634 @default.
- W2134160513 cites W2145466675 @default.
- W2134160513 cites W2148263031 @default.
- W2134160513 cites W2149796281 @default.
- W2134160513 cites W2161607615 @default.
- W2134160513 cites W2163984817 @default.
- W2134160513 cites W2166947338 @default.
- W2134160513 cites W2168959461 @default.
- W2134160513 cites W2168998401 @default.
- W2134160513 doi "https://doi.org/10.1378/chest.12-2664" @default.
- W2134160513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23880677" @default.
- W2134160513 hasPublicationYear "2013" @default.
- W2134160513 type Work @default.
- W2134160513 sameAs 2134160513 @default.
- W2134160513 citedByCount "526" @default.
- W2134160513 countsByYear W21341605132013 @default.
- W2134160513 countsByYear W21341605132014 @default.
- W2134160513 countsByYear W21341605132015 @default.
- W2134160513 countsByYear W21341605132016 @default.
- W2134160513 countsByYear W21341605132017 @default.
- W2134160513 countsByYear W21341605132018 @default.
- W2134160513 countsByYear W21341605132019 @default.
- W2134160513 countsByYear W21341605132020 @default.
- W2134160513 countsByYear W21341605132021 @default.
- W2134160513 countsByYear W21341605132022 @default.