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• W2134176045 abstract "Eukaryotes have evolved complex cellular responses to double-stranded RNA. The quantities of short interfering RNA (siRNA) can be determined rapidly by using 96-well arrays of the carnation Italian ringspot virus (CIRV) p19 protein, which binds double-stranded siRNAs with nanomolar affinity and discriminates siRNA according to length. Two compounds were found to inhibit siRNA binding to CIRV p19 by alkylating active-site cysteine residues (see diagram). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z603284_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article." @default.
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• W2134176045 date "2007-03-02" @default.
• W2134176045 modified "2023-10-17" @default.
• W2134176045 title "Inhibition of siRNA Binding to a p19 Viral Suppressor of RNA Silencing by Cysteine Alkylation" @default.
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• W2134176045 doi "https://doi.org/10.1002/anie.200603284" @default.
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