Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134186952> ?p ?o ?g. }
- W2134186952 endingPage "1541" @default.
- W2134186952 startingPage "1531" @default.
- W2134186952 abstract "Abstract Traumatic brain injury (TBI) is a significant public health problem in the United States. Despite preclinical success of various drugs, to date all clinical trials investigating potential therapeutics have failed. Recently, sex steroid hormones have sparked interest as possible neuroprotective agents after traumatic injury. One of these is 17β-estradiol (E2), the most abundant and potent endogenous vertebrate estrogen. The goal of our study was to investigate the acute potential protective effects of E2 or the specific G protein-coupled estrogen receptor 1 (GPER) agonist G-1 when administered in an intravenous bolus dose 1 hour post-injury in the lateral fluid percussion (LFP) rodent model of TBI. The results of this study show that, when assessed at 24 hours post-injury, E2 or G-1 confers protection in adult male rats subjected to LFP brain injury. Specifically, we found that an acute bolus dose of E2 or G-1 administered intravenously 1 hour post-TBI significantly increases neuronal survival in the ipsilateral CA 2/3 region of the hippocampus and decreases neuronal degeneration and apoptotic cell death in both the ipsilateral cortex and CA 2/3 region of the hippocampus. We also report a significant reduction in astrogliosis in the ipsilateral cortex, hilus, and CA 2/3 region of the hippocampus. Finally, these effects were observed to be chiefly dose-dependent for E2, with the 5 mg/kg dose generating a more robust level of protection. Our findings further elucidate estrogenic compounds as a clinically relevant pharmacotherapeutic strategy for treatment of secondary injury following TBI, and intriguingly, reveal a novel potential therapeutic target in GPER." @default.
- W2134186952 created "2016-06-24" @default.
- W2134186952 creator A5012098881 @default.
- W2134186952 creator A5022588042 @default.
- W2134186952 creator A5082848118 @default.
- W2134186952 creator A5085171919 @default.
- W2134186952 creator A5090005178 @default.
- W2134186952 date "2013-09-01" @default.
- W2134186952 modified "2023-10-02" @default.
- W2134186952 title "17<i>β</i>-Estradiol Confers Protection after Traumatic Brain Injury in the Rat and Involves Activation of G Protein-Coupled Estrogen Receptor 1" @default.
- W2134186952 cites W1545243252 @default.
- W2134186952 cites W1606732951 @default.
- W2134186952 cites W1965316850 @default.
- W2134186952 cites W1970991292 @default.
- W2134186952 cites W1971213127 @default.
- W2134186952 cites W1973124350 @default.
- W2134186952 cites W1974915539 @default.
- W2134186952 cites W1977529472 @default.
- W2134186952 cites W1977864670 @default.
- W2134186952 cites W1984187734 @default.
- W2134186952 cites W1984259765 @default.
- W2134186952 cites W1985762058 @default.
- W2134186952 cites W199598560 @default.
- W2134186952 cites W1996393215 @default.
- W2134186952 cites W1998695362 @default.
- W2134186952 cites W1999934730 @default.
- W2134186952 cites W2013661047 @default.
- W2134186952 cites W2014890825 @default.
- W2134186952 cites W2017181431 @default.
- W2134186952 cites W2020019327 @default.
- W2134186952 cites W2021742640 @default.
- W2134186952 cites W2024344832 @default.
- W2134186952 cites W2026337413 @default.
- W2134186952 cites W2037638880 @default.
- W2134186952 cites W2040053467 @default.
- W2134186952 cites W2041183073 @default.
- W2134186952 cites W2045557070 @default.
- W2134186952 cites W2045964757 @default.
- W2134186952 cites W2050410777 @default.
- W2134186952 cites W2051600991 @default.
- W2134186952 cites W2051638429 @default.
- W2134186952 cites W2054642828 @default.
- W2134186952 cites W2059794064 @default.
- W2134186952 cites W2066333062 @default.
- W2134186952 cites W2073814752 @default.
- W2134186952 cites W2075443461 @default.
- W2134186952 cites W2077915411 @default.
- W2134186952 cites W2080245596 @default.
- W2134186952 cites W2081319561 @default.
- W2134186952 cites W2081727473 @default.
- W2134186952 cites W2084865057 @default.
- W2134186952 cites W2084969905 @default.
- W2134186952 cites W2090505019 @default.
- W2134186952 cites W2096665423 @default.
- W2134186952 cites W2101600318 @default.
- W2134186952 cites W2101676857 @default.
- W2134186952 cites W2102314603 @default.
- W2134186952 cites W2116455640 @default.
- W2134186952 cites W2120770581 @default.
- W2134186952 cites W2129309010 @default.
- W2134186952 cites W2129858888 @default.
- W2134186952 cites W2136414795 @default.
- W2134186952 cites W2138364951 @default.
- W2134186952 cites W2140179339 @default.
- W2134186952 cites W2146152680 @default.
- W2134186952 cites W2146373526 @default.
- W2134186952 cites W2147783395 @default.
- W2134186952 cites W2154414488 @default.
- W2134186952 cites W2155723654 @default.
- W2134186952 cites W2159148254 @default.
- W2134186952 cites W2160464746 @default.
- W2134186952 cites W2162258317 @default.
- W2134186952 cites W2163508877 @default.
- W2134186952 cites W2165807863 @default.
- W2134186952 cites W2170728568 @default.
- W2134186952 cites W2736091234 @default.
- W2134186952 cites W4251522453 @default.
- W2134186952 cites W4297069145 @default.
- W2134186952 doi "https://doi.org/10.1089/neu.2013.2854" @default.
- W2134186952 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3751264" @default.
- W2134186952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23659385" @default.
- W2134186952 hasPublicationYear "2013" @default.
- W2134186952 type Work @default.
- W2134186952 sameAs 2134186952 @default.
- W2134186952 citedByCount "79" @default.
- W2134186952 countsByYear W21341869522014 @default.
- W2134186952 countsByYear W21341869522015 @default.
- W2134186952 countsByYear W21341869522016 @default.
- W2134186952 countsByYear W21341869522017 @default.
- W2134186952 countsByYear W21341869522018 @default.
- W2134186952 countsByYear W21341869522019 @default.
- W2134186952 countsByYear W21341869522020 @default.
- W2134186952 countsByYear W21341869522021 @default.
- W2134186952 countsByYear W21341869522022 @default.
- W2134186952 countsByYear W21341869522023 @default.
- W2134186952 crossrefType "journal-article" @default.
- W2134186952 hasAuthorship W2134186952A5012098881 @default.
- W2134186952 hasAuthorship W2134186952A5022588042 @default.