Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134187603> ?p ?o ?g. }
- W2134187603 endingPage "575" @default.
- W2134187603 startingPage "570" @default.
- W2134187603 abstract "The cellular receptor for Epstein-Barr virus (EBV) is the type 2 complement receptor, CD21. At initial infection, EBV virion glycoproteins gp350 and gp220 bind to CD21. We report here that the cross-linking of CD21 by gp350/220 results in increased amounts of interleukin 6 (IL-6) RNA and IL-6 protein. This effect could be blocked with anti-gp350/220 and anti-CD21 monoclonal antibodies. Induction of IL-6 in B cells by EBV could be mimicked by treatment with the protein kinase C (PKC) activator phorbol 12,13-dibutyrate but not with the calcium ionophore ionomycin. IL-6 induction by EBV was inhibited with the PKC-specific inhibitor bisindolylmaleimide or the protein tyrosine kinase inhibitors methyl 2,5-dihydroxycinnamate and herbimycin A, indicating that the induction of IL-6 following CD21 cross-linking is mediated through PKC- and protein tyrosine kinase-dependent pathways." @default.
- W2134187603 created "2016-06-24" @default.
- W2134187603 creator A5017186738 @default.
- W2134187603 creator A5059704436 @default.
- W2134187603 creator A5065954062 @default.
- W2134187603 creator A5074508362 @default.
- W2134187603 date "1996-01-01" @default.
- W2134187603 modified "2023-10-18" @default.
- W2134187603 title "Induction of interleukin-6 after stimulation of human B-cell CD21 by Epstein-Barr virus glycoproteins gp350 and gp220" @default.
- W2134187603 cites W122909865 @default.
- W2134187603 cites W1464260600 @default.
- W2134187603 cites W1500732610 @default.
- W2134187603 cites W1501353479 @default.
- W2134187603 cites W1524173502 @default.
- W2134187603 cites W1560812794 @default.
- W2134187603 cites W1569792747 @default.
- W2134187603 cites W1585469912 @default.
- W2134187603 cites W1602152102 @default.
- W2134187603 cites W1642607010 @default.
- W2134187603 cites W1755902553 @default.
- W2134187603 cites W1777081626 @default.
- W2134187603 cites W1839088367 @default.
- W2134187603 cites W1943277847 @default.
- W2134187603 cites W1972624990 @default.
- W2134187603 cites W1983466527 @default.
- W2134187603 cites W2001123146 @default.
- W2134187603 cites W2012150565 @default.
- W2134187603 cites W2014588425 @default.
- W2134187603 cites W2035501359 @default.
- W2134187603 cites W2037148516 @default.
- W2134187603 cites W2040653220 @default.
- W2134187603 cites W204290839 @default.
- W2134187603 cites W2047193748 @default.
- W2134187603 cites W2063170571 @default.
- W2134187603 cites W2068013575 @default.
- W2134187603 cites W2076214287 @default.
- W2134187603 cites W2078225503 @default.
- W2134187603 cites W2092599452 @default.
- W2134187603 cites W2095614489 @default.
- W2134187603 cites W2100092765 @default.
- W2134187603 cites W2100916300 @default.
- W2134187603 cites W2119460480 @default.
- W2134187603 cites W2120048893 @default.
- W2134187603 cites W2130694207 @default.
- W2134187603 cites W2342416246 @default.
- W2134187603 cites W2403121196 @default.
- W2134187603 cites W252613826 @default.
- W2134187603 cites W341470327 @default.
- W2134187603 doi "https://doi.org/10.1128/jvi.70.1.570-575.1996" @default.
- W2134187603 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/189846" @default.
- W2134187603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8523572" @default.
- W2134187603 hasPublicationYear "1996" @default.
- W2134187603 type Work @default.
- W2134187603 sameAs 2134187603 @default.
- W2134187603 citedByCount "58" @default.
- W2134187603 countsByYear W21341876032013 @default.
- W2134187603 countsByYear W21341876032014 @default.
- W2134187603 countsByYear W21341876032015 @default.
- W2134187603 countsByYear W21341876032019 @default.
- W2134187603 countsByYear W21341876032020 @default.
- W2134187603 countsByYear W21341876032022 @default.
- W2134187603 countsByYear W21341876032023 @default.
- W2134187603 crossrefType "journal-article" @default.
- W2134187603 hasAuthorship W2134187603A5017186738 @default.
- W2134187603 hasAuthorship W2134187603A5059704436 @default.
- W2134187603 hasAuthorship W2134187603A5065954062 @default.
- W2134187603 hasAuthorship W2134187603A5074508362 @default.
- W2134187603 hasBestOaLocation W21341876031 @default.
- W2134187603 hasConcept C153911025 @default.
- W2134187603 hasConcept C195794163 @default.
- W2134187603 hasConcept C2776989580 @default.
- W2134187603 hasConcept C42362537 @default.
- W2134187603 hasConcept C62478195 @default.
- W2134187603 hasConcept C79879829 @default.
- W2134187603 hasConcept C86803240 @default.
- W2134187603 hasConcept C95444343 @default.
- W2134187603 hasConceptScore W2134187603C153911025 @default.
- W2134187603 hasConceptScore W2134187603C195794163 @default.
- W2134187603 hasConceptScore W2134187603C2776989580 @default.
- W2134187603 hasConceptScore W2134187603C42362537 @default.
- W2134187603 hasConceptScore W2134187603C62478195 @default.
- W2134187603 hasConceptScore W2134187603C79879829 @default.
- W2134187603 hasConceptScore W2134187603C86803240 @default.
- W2134187603 hasConceptScore W2134187603C95444343 @default.
- W2134187603 hasIssue "1" @default.
- W2134187603 hasLocation W21341876031 @default.
- W2134187603 hasLocation W21341876032 @default.
- W2134187603 hasLocation W21341876033 @default.
- W2134187603 hasLocation W21341876034 @default.
- W2134187603 hasOpenAccess W2134187603 @default.
- W2134187603 hasPrimaryLocation W21341876031 @default.
- W2134187603 hasRelatedWork W1898841977 @default.
- W2134187603 hasRelatedWork W2027536502 @default.
- W2134187603 hasRelatedWork W2055548118 @default.
- W2134187603 hasRelatedWork W2075204103 @default.
- W2134187603 hasRelatedWork W2090230710 @default.
- W2134187603 hasRelatedWork W2118751492 @default.
- W2134187603 hasRelatedWork W2157596541 @default.