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• W2134216098 abstract "The rate of meiotic crossing over (CO) varies considerably along chromosomes, leading to marked distortions between physical and genetic distances. The causes underlying this variation are being unraveled, and DNA sequence and chromatin states have emerged as key factors. However, the extent to which the suppression of COs within the repeat-rich pericentromeric regions of plant and mammalian chromosomes results from their high level of DNA polymorphisms and from their heterochromatic state, notably their dense DNA methylation, remains unknown. Here, we test the combined effect of removing sequence polymorphisms and repeat-associated DNA methylation on the meiotic recombination landscape of an Arabidopsis mapping population. To do so, we use genome-wide DNA methylation data from a large panel of isogenic epigenetic recombinant inbred lines (epiRILs) to derive a recombination map based on 126 meiotically stable, differentially methylated regions covering 81.9% of the genome. We demonstrate that the suppression of COs within pericentromeric regions of chromosomes persists in this experimental setting. Moreover, suppression is reinforced within 3-Mb regions flanking pericentromeric boundaries, and this effect appears to be compensated by increased recombination activity in chromosome arms. A direct comparison with 17 classical Arabidopsis crosses shows that these recombination changes place the epiRILs at the boundary of the range of natural variation but are not severe enough to transgress that boundary significantly. This level of robustness is remarkable, considering that this population represents an extreme with key recombination barriers having been forced to a minimum." @default.
• W2134216098 created "2016-06-24" @default.
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• W2134216098 date "2012-09-17" @default.
• W2134216098 modified "2023-10-12" @default.
• W2134216098 title "Features of the <i>Arabidopsis</i> recombination landscape resulting from the combined loss of sequence variation and DNA methylation" @default.
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• W2134216098 doi "https://doi.org/10.1073/pnas.1212955109" @default.
• W2134216098 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3479620" @default.
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• W2134216098 hasPublicationYear "2012" @default.
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