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- W2134220633 abstract "Nrf2 is a key transcription factor for antioxidant response element (ARE)-bearing genes involved in diverse host defense functions including redox balance, cell cycle, immunity, mitochondrial biogenesis, energy metabolism, and carcinogenesis. Nrf2 in the airways is particularly essential as the respiratory system continuously interfaces with environmental stress. Since Nrf2 was determined to be a susceptibility gene for a model of acute lung injury, its protective capacity in the airways has been demonstrated in experimental models of human disorders using Nrf2 mutant mice which were susceptible to supplemental respiratory therapy (e.g., hyperoxia, mechanical ventilation), cigarette smoke, allergens, virus, environmental pollutants, and fibrotic agents compared to wild-type littermates. Recent studies also determined that Nrf2 is indispensable in developmental lung injury. While association studies with genetic NRF2 polymorphisms supported a protective role for murine Nrf2 in oxidative airway diseases, somatic NRF2 mutations enhanced NRF2–ARE responses, and were favorable for lung carcinogenesis and chemoresistance. Bioinformatic tools have elucidated direct Nrf2 targets as well as Nrf2-interacting networks. Moreover, potent Nrf2–ARE agonists protected oxidant-induced lung phenotypes in model systems, suggesting a therapeutic or preventive intervention. Further investigations on Nrf2 should yield greater understanding of its contribution to normal and pathophysiological function in the airways." @default.
- W2134220633 created "2016-06-24" @default.
- W2134220633 creator A5033845712 @default.
- W2134220633 creator A5042008454 @default.
- W2134220633 date "2015-07-21" @default.
- W2134220633 modified "2023-09-27" @default.
- W2134220633 title "Association of Nrf2 with airway pathogenesis: lessons learned from genetic mouse models" @default.
- W2134220633 cites W1492029572 @default.
- W2134220633 cites W1499978168 @default.
- W2134220633 cites W1528331455 @default.
- W2134220633 cites W1561096292 @default.
- W2134220633 cites W1587614700 @default.
- W2134220633 cites W1631169176 @default.
- W2134220633 cites W1655204455 @default.
- W2134220633 cites W1683287975 @default.
- W2134220633 cites W1785455093 @default.
- W2134220633 cites W1816432249 @default.
- W2134220633 cites W1850426716 @default.
- W2134220633 cites W1893923004 @default.
- W2134220633 cites W1948225098 @default.
- W2134220633 cites W1965710010 @default.
- W2134220633 cites W1965740485 @default.
- W2134220633 cites W1967108243 @default.
- W2134220633 cites W1971688317 @default.
- W2134220633 cites W1972611112 @default.
- W2134220633 cites W1973717550 @default.
- W2134220633 cites W1973882427 @default.
- W2134220633 cites W1974546855 @default.
- W2134220633 cites W1975633275 @default.
- W2134220633 cites W1977736016 @default.
- W2134220633 cites W1977804319 @default.
- W2134220633 cites W1977905350 @default.
- W2134220633 cites W1980938313 @default.
- W2134220633 cites W1984695893 @default.
- W2134220633 cites W1986740442 @default.
- W2134220633 cites W1989491973 @default.
- W2134220633 cites W1991631628 @default.
- W2134220633 cites W1992724001 @default.
- W2134220633 cites W1997991819 @default.
- W2134220633 cites W1998560601 @default.
- W2134220633 cites W1998641419 @default.
- W2134220633 cites W1998952704 @default.
- W2134220633 cites W1999113566 @default.
- W2134220633 cites W2000017694 @default.
- W2134220633 cites W2001568293 @default.
- W2134220633 cites W2001699925 @default.
- W2134220633 cites W2001990797 @default.
- W2134220633 cites W2003012793 @default.
- W2134220633 cites W2003016739 @default.
- W2134220633 cites W2003917660 @default.
- W2134220633 cites W2004288386 @default.
- W2134220633 cites W2005276545 @default.
- W2134220633 cites W2005334314 @default.
- W2134220633 cites W2007714594 @default.
- W2134220633 cites W2009631807 @default.
- W2134220633 cites W2009842499 @default.
- W2134220633 cites W2012039125 @default.
- W2134220633 cites W2013092934 @default.
- W2134220633 cites W2014957651 @default.
- W2134220633 cites W2016145760 @default.
- W2134220633 cites W2016603108 @default.
- W2134220633 cites W2018781131 @default.
- W2134220633 cites W2018839292 @default.
- W2134220633 cites W2019040339 @default.
- W2134220633 cites W2019122701 @default.
- W2134220633 cites W2020592110 @default.
- W2134220633 cites W2021575226 @default.
- W2134220633 cites W2021935368 @default.
- W2134220633 cites W2022697357 @default.
- W2134220633 cites W2023410485 @default.
- W2134220633 cites W2024406112 @default.
- W2134220633 cites W2024483876 @default.
- W2134220633 cites W2025054234 @default.
- W2134220633 cites W2025713572 @default.
- W2134220633 cites W2025801301 @default.
- W2134220633 cites W2026488076 @default.
- W2134220633 cites W2026982091 @default.
- W2134220633 cites W2027079842 @default.
- W2134220633 cites W2027085316 @default.
- W2134220633 cites W2027388164 @default.
- W2134220633 cites W2027976516 @default.
- W2134220633 cites W2028608472 @default.
- W2134220633 cites W2029031136 @default.
- W2134220633 cites W2030867249 @default.
- W2134220633 cites W2034388777 @default.
- W2134220633 cites W2034411287 @default.
- W2134220633 cites W2035295644 @default.
- W2134220633 cites W2037701894 @default.
- W2134220633 cites W2038346583 @default.
- W2134220633 cites W2038459149 @default.
- W2134220633 cites W2038584506 @default.
- W2134220633 cites W2040834776 @default.
- W2134220633 cites W2041112507 @default.
- W2134220633 cites W2042148267 @default.
- W2134220633 cites W2043180376 @default.
- W2134220633 cites W2043281296 @default.
- W2134220633 cites W2044944825 @default.
- W2134220633 cites W2048935707 @default.