FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134231719> ?p ?o ?g. }

• W2134231719 endingPage "1963" @default.
• W2134231719 startingPage "1956" @default.
• W2134231719 abstract "The degree of applicability of chemogenomic approaches to protein families depends on the accuracy and completeness of pharmacological data and the corresponding level of pharmacological similarity observed among their protein members. The recent public domain availability of pharmacological data for thousands of small molecules on 204 G protein- coupled receptors (GPCRs) provides a firm basis for an in-depth cross-pharmacology analysis of this superfamily. The number of protein targets included in the cross-pharmacology profile of the different GPCRs changes significantly upon varying the ligand similarity and binding affinity criteria. However, with the exception of muscarinic receptors, aminergic GPCRs distinguish themselves from the rest of the members in the family by their remarkably high levels of pharmacological similarity among them. Clusters of non-GPCR targets related by cross-pharmacology with particular GPCRs are identified and the implications for unwanted side-effects, as well as for repurposing opportunities, discussed. Keywords: GPCR network, ligand similarity, target profile, adverse effects, drug repositioning, pharmacological similarity, cross-pharmacology analysis, muscarinic receptors,, Clusters of non-GPCR targets, GPCR-directed chemical libraries, crosspharmacology signals, Chemogenomic Databases" @default.
• W2134231719 created "2016-06-24" @default.
• W2134231719 creator A5052116809 @default.
• W2134231719 creator A5061685157 @default.
• W2134231719 creator A5067062016 @default.
• W2134231719 creator A5090915185 @default.
• W2134231719 date "2011-08-01" @default.
• W2134231719 modified "2023-10-16" @default.
• W2134231719 title "Cross-Pharmacology Analysis of G Protein-Coupled Receptors" @default.
• W2134231719 cites W1546400389 @default.
• W2134231719 cites W1970599746 @default.
• W2134231719 cites W1972678028 @default.
• W2134231719 cites W1972821149 @default.
• W2134231719 cites W1974477738 @default.
• W2134231719 cites W1980607140 @default.
• W2134231719 cites W1990065809 @default.
• W2134231719 cites W1992578437 @default.
• W2134231719 cites W1996528078 @default.
• W2134231719 cites W1998554645 @default.
• W2134231719 cites W1999591184 @default.
• W2134231719 cites W2005329278 @default.
• W2134231719 cites W2009313526 @default.
• W2134231719 cites W2014203427 @default.
• W2134231719 cites W2019547529 @default.
• W2134231719 cites W2028733293 @default.
• W2134231719 cites W2031372687 @default.
• W2134231719 cites W2047314546 @default.
• W2134231719 cites W2057280422 @default.
• W2134231719 cites W2068271330 @default.
• W2134231719 cites W2080886752 @default.
• W2134231719 cites W2082982490 @default.
• W2134231719 cites W2096864392 @default.
• W2134231719 cites W2114068014 @default.
• W2134231719 cites W2116249365 @default.
• W2134231719 cites W2122995608 @default.
• W2134231719 cites W2124821916 @default.
• W2134231719 cites W2129637200 @default.
• W2134231719 cites W2138512826 @default.
• W2134231719 cites W2148972970 @default.
• W2134231719 cites W2153341679 @default.
• W2134231719 cites W2155894387 @default.
• W2134231719 cites W2171844672 @default.
• W2134231719 cites W2177544602 @default.
• W2134231719 cites W2200017991 @default.
• W2134231719 cites W2950510360 @default.
• W2134231719 cites W2993383518 @default.
• W2134231719 doi "https://doi.org/10.2174/156802611796391285" @default.
• W2134231719 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3717414" @default.
• W2134231719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21851335" @default.
• W2134231719 hasPublicationYear "2011" @default.
• W2134231719 type Work @default.
• W2134231719 sameAs 2134231719 @default.
• W2134231719 citedByCount "35" @default.
• W2134231719 countsByYear W21342317192012 @default.
• W2134231719 countsByYear W21342317192013 @default.
• W2134231719 countsByYear W21342317192014 @default.
• W2134231719 countsByYear W21342317192015 @default.
• W2134231719 countsByYear W21342317192017 @default.
• W2134231719 countsByYear W21342317192018 @default.
• W2134231719 countsByYear W21342317192019 @default.
• W2134231719 countsByYear W21342317192022 @default.
• W2134231719 countsByYear W21342317192023 @default.
• W2134231719 crossrefType "journal-article" @default.
• W2134231719 hasAuthorship W2134231719A5052116809 @default.
• W2134231719 hasAuthorship W2134231719A5061685157 @default.
• W2134231719 hasAuthorship W2134231719A5067062016 @default.
• W2134231719 hasAuthorship W2134231719A5090915185 @default.
• W2134231719 hasBestOaLocation W21342317192 @default.
• W2134231719 hasConcept C103278499 @default.
• W2134231719 hasConcept C103637391 @default.
• W2134231719 hasConcept C115961682 @default.
• W2134231719 hasConcept C135285700 @default.
• W2134231719 hasConcept C139489369 @default.
• W2134231719 hasConcept C154945302 @default.
• W2134231719 hasConcept C170493617 @default.
• W2134231719 hasConcept C18903297 @default.
• W2134231719 hasConcept C2780035454 @default.
• W2134231719 hasConcept C33789571 @default.
• W2134231719 hasConcept C41008148 @default.
• W2134231719 hasConcept C519536355 @default.
• W2134231719 hasConcept C55493867 @default.
• W2134231719 hasConcept C60644358 @default.
• W2134231719 hasConcept C70721500 @default.
• W2134231719 hasConcept C74187038 @default.
• W2134231719 hasConcept C86803240 @default.
• W2134231719 hasConcept C98274493 @default.
• W2134231719 hasConceptScore W2134231719C103278499 @default.
• W2134231719 hasConceptScore W2134231719C103637391 @default.
• W2134231719 hasConceptScore W2134231719C115961682 @default.
• W2134231719 hasConceptScore W2134231719C135285700 @default.
• W2134231719 hasConceptScore W2134231719C139489369 @default.
• W2134231719 hasConceptScore W2134231719C154945302 @default.
• W2134231719 hasConceptScore W2134231719C170493617 @default.
• W2134231719 hasConceptScore W2134231719C18903297 @default.
• W2134231719 hasConceptScore W2134231719C2780035454 @default.
• W2134231719 hasConceptScore W2134231719C33789571 @default.
• W2134231719 hasConceptScore W2134231719C41008148 @default.
• W2134231719 hasConceptScore W2134231719C519536355 @default.

• next