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• W2134233049 abstract "IL-17R signaling is required for control of extracellular pathogens and is also implicated in development of chronic inflammatory processes. The response to the human pathogen <i>Helicobacter pylori</i> results in Th1 and Th17 cell activation and a chronic inflammatory process that can lead to adverse outcomes, such as gastric cancer. Previously, we identified IL-17RA as a requirement for the recruitment of neutrophils and control of <i>H. pylori</i> colonization in the gastric mucosa. Unexpectedly, <i>H. pylori</i>–infected <i>Il17ra</i>^−/− mice had significantly more chronic inflammation than <i>H. pylori</i>–infected wild-type mice. In this study, human epithelial cell lines and murine models were used to investigate differential roles for IL-17A, IL-17F, and IL-17A/F during <i>H. pylori</i> infection. Moreover, the hypothesis that IL-17RA signaling, specifically in lymphocytes, provides an autocrine feedback loop that downregulates Th17 cytokine production was investigated. The data indicate that epithelial cells exhibit a stronger response to IL-17A and IL-17A/F than IL-17F, and that IL-17A and IL-17A/F can synergize with TNF and IL-22 to induce antimicrobial genes of gastric epithelial cells. In vivo deficiencies of IL-17A or IL-17F alone did not significantly change the immunopathological response to <i>H. pylori</i>, but if both cytokines were absent, a hyperinflammatory lymphocytic response developed. Using a cre/flox targeting approach for IL-17RA combined with infection, our findings demonstrate that increased chronic inflammation in <i>Il17ra</i>^−/− mice was not attributed to a T cell–intrinsic defect. These data imply that IL-17A and IL-17F may have overlapping roles in maintenance of the gastric mucosal response to infection." @default.
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• W2134233049 date "2005-05-01" @default.
• W2134233049 modified "2023-10-16" @default.
• W2134233049 title "A comparative study of continuous positive airway pressure (CPAP) and intermittent positive pressure ventilation (IPPV) in patients with flail chest" @default.
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• W2134233049 doi "https://doi.org/10.1136/emj.2004.019786" @default.
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