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- W2134233658 abstract "Platelet factor-4 (CXCL4/PF-4) is the first chemokine identified to have several biological functions. Notably, CXCL4/PF-4 inhibits endothelial cell proliferation and migration, leading to suppression of angiogenesis. Since angiogenesis is essential for the growth of most primary tumors and their subsequent metastases, it is a target for cancer therapy; due to its multiple functions, CXCL4/PF-4 is a potential clinical anti-tumor agent. This report reviews the mechanisms of CXCL4/PF-4 angiostatic activity, including interference with angiogenic growth factors bFGF-2 and VEGF165, activation of CXCR3B, interactions with integrins, interference with cell cycle, interactions with factors such as VEGF121 and CXCL8/IL-8, and derived molecules of CXCL4/PF-4 with angiostatic and anti-tumoral activities in different models in vivo or in vitro." @default.
- W2134233658 created "2016-06-24" @default.
- W2134233658 creator A5056053058 @default.
- W2134233658 creator A5088996718 @default.
- W2134233658 date "2013-05-01" @default.
- W2134233658 modified "2023-09-27" @default.
- W2134233658 title "Platelet factor-4 (CXCL4/PF-4): An angiostatic chemokine for cancer therapy" @default.
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- W2134233658 doi "https://doi.org/10.1016/j.canlet.2013.01.006" @default.
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