FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134261638> ?p ?o ?g. }

• W2134261638 endingPage "758" @default.
• W2134261638 startingPage "745" @default.
• W2134261638 abstract "An operon encoding a member of the family of ATP-binding cassette (ABC) divalent metal ion transporters, homologous to Salmonella enterica SitABCD, has been identified in the avian pathogenic Escherichia coli (APEC) strain chi7122. The sitABCD genes were located on the virulence plasmid pAPEC-1, and were highly similar at the nucleotide level to the chromosomally encoded sitABCD genes present in Shigella spp. A cloned copy of sitABCD conferred increased growth upon a siderophore-deficient E. coli strain grown in nutrient broth supplemented with the chelator 2,2'-dipyridyl. Ion rescue demonstrated that Sit-mediated growth promotion of this strain was due to the transport of iron. SitABCD mediated increased transport of both iron and manganese as demonstrated by uptake of 55Fe, 59Fe or 54Mn in E. coli K-12 strains deficient for the transport of iron (aroB feoB) and manganese (mntH) respectively. Isotope uptake and transport inhibition studies showed that in the iron transport deficient strain, SitABCD demonstrated a greater affinity for iron than for manganese, and SitABCD-mediated transport was higher for ferrous iron, whereas in the manganese transport deficient strain, SitABCD demonstrated greater affinity for manganese than for iron. Introduction of the APEC sitABCD genes into an E. coli K-12 mntH mutant also conferred increased resistance to the bactericidal effects of hydrogen peroxide. APEC strain chi7122 derivatives lacking either a functional SitABCD or a functional MntH transport system were as resistant to hydrogen peroxide as the wild-type strain, whereas a Deltasit DeltamntH double mutant was more sensitive to hydrogen peroxide. Overall, the results demonstrate that in E. coli SitABCD represents a manganese and iron transporter that, in combination with other ion transport systems, may contribute to acquisition of iron and manganese, and resistance to oxidative stress." @default.
• W2134261638 created "2016-06-24" @default.
• W2134261638 creator A5014732418 @default.
• W2134261638 creator A5041308273 @default.
• W2134261638 creator A5065155909 @default.
• W2134261638 date "2006-03-01" @default.
• W2134261638 modified "2023-10-16" @default.
• W2134261638 title "A SitABCD homologue from an avian pathogenic Escherichia coli strain mediates transport of iron and manganese and resistance to hydrogen peroxide" @default.
• W2134261638 cites W1550924159 @default.
• W2134261638 cites W1599185587 @default.
• W2134261638 cites W1690413094 @default.
• W2134261638 cites W1797056465 @default.
• W2134261638 cites W1840984592 @default.
• W2134261638 cites W1899866601 @default.
• W2134261638 cites W1982245868 @default.
• W2134261638 cites W1996423252 @default.
• W2134261638 cites W2013740990 @default.
• W2134261638 cites W2014723793 @default.
• W2134261638 cites W2026849306 @default.
• W2134261638 cites W2035853723 @default.
• W2134261638 cites W2036002192 @default.
• W2134261638 cites W2054941036 @default.
• W2134261638 cites W2056764669 @default.
• W2134261638 cites W2058543906 @default.
• W2134261638 cites W2059041636 @default.
• W2134261638 cites W2062340271 @default.
• W2134261638 cites W2064006139 @default.
• W2134261638 cites W2068595308 @default.
• W2134261638 cites W2069531855 @default.
• W2134261638 cites W2072058887 @default.
• W2134261638 cites W2080681701 @default.
• W2134261638 cites W2092371691 @default.
• W2134261638 cites W2096974471 @default.
• W2134261638 cites W2098863862 @default.
• W2134261638 cites W2099910134 @default.
• W2134261638 cites W2104920426 @default.
• W2134261638 cites W2106471610 @default.
• W2134261638 cites W2112111992 @default.
• W2134261638 cites W2112271889 @default.
• W2134261638 cites W2115422910 @default.
• W2134261638 cites W2116137883 @default.
• W2134261638 cites W2117944021 @default.
• W2134261638 cites W2120681623 @default.
• W2134261638 cites W2125736213 @default.
• W2134261638 cites W2127242142 @default.
• W2134261638 cites W2131257296 @default.
• W2134261638 cites W2131282911 @default.
• W2134261638 cites W2133130415 @default.
• W2134261638 cites W2133859270 @default.
• W2134261638 cites W2136107297 @default.
• W2134261638 cites W2137147102 @default.
• W2134261638 cites W2141653906 @default.
• W2134261638 cites W2142120140 @default.
• W2134261638 cites W2153139855 @default.
• W2134261638 cites W2153438211 @default.
• W2134261638 cites W2154075906 @default.
• W2134261638 cites W2156691801 @default.
• W2134261638 cites W2161848999 @default.
• W2134261638 cites W2164938799 @default.
• W2134261638 cites W4240641938 @default.
• W2134261638 cites W88493969 @default.
• W2134261638 doi "https://doi.org/10.1099/mic.0.28682-0" @default.
• W2134261638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16514154" @default.
• W2134261638 hasPublicationYear "2006" @default.
• W2134261638 type Work @default.
• W2134261638 sameAs 2134261638 @default.
• W2134261638 citedByCount "134" @default.
• W2134261638 countsByYear W21342616382012 @default.
• W2134261638 countsByYear W21342616382013 @default.
• W2134261638 countsByYear W21342616382014 @default.
• W2134261638 countsByYear W21342616382015 @default.
• W2134261638 countsByYear W21342616382016 @default.
• W2134261638 countsByYear W21342616382017 @default.
• W2134261638 countsByYear W21342616382018 @default.
• W2134261638 countsByYear W21342616382019 @default.
• W2134261638 countsByYear W21342616382020 @default.
• W2134261638 countsByYear W21342616382021 @default.
• W2134261638 countsByYear W21342616382022 @default.
• W2134261638 countsByYear W21342616382023 @default.
• W2134261638 crossrefType "journal-article" @default.
• W2134261638 hasAuthorship W2134261638A5014732418 @default.
• W2134261638 hasAuthorship W2134261638A5041308273 @default.
• W2134261638 hasAuthorship W2134261638A5065155909 @default.
• W2134261638 hasConcept C104317684 @default.
• W2134261638 hasConcept C105702510 @default.
• W2134261638 hasConcept C108319773 @default.
• W2134261638 hasConcept C143065580 @default.
• W2134261638 hasConcept C178790620 @default.
• W2134261638 hasConcept C185592680 @default.
• W2134261638 hasConcept C203075996 @default.
• W2134261638 hasConcept C2775832776 @default.
• W2134261638 hasConcept C2778022156 @default.
• W2134261638 hasConcept C2779607309 @default.
• W2134261638 hasConcept C528890316 @default.
• W2134261638 hasConcept C533411734 @default.
• W2134261638 hasConcept C547475151 @default.
• W2134261638 hasConcept C55493867 @default.
• W2134261638 hasConcept C86803240 @default.

• next