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• W2134261661 startingPage "211" @default.
• W2134261661 abstract "Increased serotonergic activity has been shown to reduce motivation to ingest, which may involve, in part, gustatory processes. Here, we examined the effect of paroxetine, a selective serotonin reuptake inhibitor, on appetitive responding for a preferred and an avoided taste solution using a progressive ratio (PR) task in which licking was employed as the operant. Male Sprague-Dawley rats (n = 8/taste stimulus) were trained to respond for a concentration series of sucrose or quinine on fixed and PR schedules of reinforcement. Performance for sucrose was assessed while the rats were partially food- and water-restricted and nondeprived, and performance for water and quinine was assessed while the rats were water-deprived. Then, the rats were injected with vehicle (10% dimethyl sulfoxide, 1mL/kg intraperitoneal [ip], -1h) or paroxetine (5mg/kg), and their responding on a PR schedule for sucrose measured when the rats were nondeprived or for water and quinine when the rats were water-deprived. Paroxetine decreased breakpoint, which was defined as the number of operant (e.g., dry) licks in the final reinforced ratio, for water, quinine, and sucrose. This demonstrates that a general systemic increase in serotonergic activity decreases the appetitive-based responses to both preferred and nonpreferred fluids under different deprivation states." @default.
• W2134261661 created "2016-06-24" @default.
• W2134261661 creator A5036082038 @default.
• W2134261661 creator A5060213227 @default.
• W2134261661 creator A5091542363 @default.
• W2134261661 date "2012-12-19" @default.
• W2134261661 modified "2023-09-26" @default.
• W2134261661 title "The Selective Serotonin Reuptake Inhibitor Paroxetine Decreases Breakpoint of Rats Engaging in a Progressive Ratio Licking Task for Sucrose and Quinine Solutions" @default.
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• W2134261661 doi "https://doi.org/10.1093/chemse/bjs096" @default.
• W2134261661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3569624" @default.
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• W2134261661 hasPublicationYear "2012" @default.
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