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- W2134261870 abstract "Autoimmune hemolytic anemia (AIHA) in children usually responds well to short-term steroid therapy. However, in some cases, AIHA requires prolonged immunosuppressive therapy, with the subsequent development of severe side effects. Compared with previous conventional immunosuppressive therapy, rituximab, an anti-CD20 chimeric monoclonal antibody, shows good therapeutic efficacy and safety in the treatment of autoimmune disorders. Herein, the case of a 13-year-old male patient, who showed a remarkable and durable response to rituximab, at a dose of 375mg/m2 , is reported. Before this trial, he had been a hepatitis B carrier and steroid dependent AIHA for 4 years, with a cushingoid facial appearance and growth retardation. After 10 months, he experienced a recurrence of hemolysis, which was successfully retreated, and was then taken off the steroid ther apy. The therapy was well tolerated, without serious complications. It is suggested that rituximab could be a new option in the treatment of steroid-dependent AIHA. Therefore, long-term follow-up and studies of the risk factors of a relapse are" @default.
- W2134261870 created "2016-06-24" @default.
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- W2134261870 date "2006-01-01" @default.
- W2134261870 modified "2023-10-18" @default.
- W2134261870 title "A Case of Autoimmune Hemolytic Anemia Treated with Rituximab in a Child" @default.
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- W2134261870 doi "https://doi.org/10.5045/kjh.2006.41.4.321" @default.
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