Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134262073> ?p ?o ?g. }
- W2134262073 endingPage "852" @default.
- W2134262073 startingPage "844" @default.
- W2134262073 abstract "Summary Primary familial and congenital polycythemia (PFCP) is an autosomal‐dominant proliferative disorder characterized by erythrocytosis and hypersensitivity of erythroid progenitors to erythropoietin (Epo). Several lines of evidence suggest a causal role of truncated erythropoietin receptor (EpoR) in this disease. In this review, we discuss PFCP in the context of erythrocytosis and EpoR signalling. We focus on recent studies describing mechanisms underlying Epo‐dependent EpoR down‐regulation. One mechanism depends on internalization mediated through the p85 regulatory subunit of the Phosphoinositide 3‐Kinase, and the other utilizes ubiquitin‐based proteasomal degradation. Truncated PFCP EpoRs are not properly down‐regulated upon stimulation, underscoring the importance of these mechanisms in the pathogenesis of PFCP." @default.
- W2134262073 created "2016-06-24" @default.
- W2134262073 creator A5013584924 @default.
- W2134262073 creator A5045731853 @default.
- W2134262073 creator A5081209681 @default.
- W2134262073 date "2010-03-01" @default.
- W2134262073 modified "2023-10-18" @default.
- W2134262073 title "Advances in understanding the pathogenesis of primary familial and congenital polycythaemia" @default.
- W2134262073 cites W1484213444 @default.
- W2134262073 cites W1488478985 @default.
- W2134262073 cites W1519792826 @default.
- W2134262073 cites W1544350757 @default.
- W2134262073 cites W1547877665 @default.
- W2134262073 cites W1549388485 @default.
- W2134262073 cites W1586781757 @default.
- W2134262073 cites W1593893099 @default.
- W2134262073 cites W1595654463 @default.
- W2134262073 cites W1668039320 @default.
- W2134262073 cites W177448191 @default.
- W2134262073 cites W1900781903 @default.
- W2134262073 cites W1977592524 @default.
- W2134262073 cites W1980082005 @default.
- W2134262073 cites W1980504189 @default.
- W2134262073 cites W1983925960 @default.
- W2134262073 cites W1988031203 @default.
- W2134262073 cites W1992895531 @default.
- W2134262073 cites W1993664053 @default.
- W2134262073 cites W2000367646 @default.
- W2134262073 cites W2002174333 @default.
- W2134262073 cites W2002782759 @default.
- W2134262073 cites W2004646106 @default.
- W2134262073 cites W2008295144 @default.
- W2134262073 cites W2009278301 @default.
- W2134262073 cites W2009621679 @default.
- W2134262073 cites W2009857536 @default.
- W2134262073 cites W2010419832 @default.
- W2134262073 cites W2013381961 @default.
- W2134262073 cites W2014420892 @default.
- W2134262073 cites W2017828532 @default.
- W2134262073 cites W2019931350 @default.
- W2134262073 cites W2020337983 @default.
- W2134262073 cites W2020562174 @default.
- W2134262073 cites W2024591653 @default.
- W2134262073 cites W2025104203 @default.
- W2134262073 cites W2029837857 @default.
- W2134262073 cites W2029939410 @default.
- W2134262073 cites W2031719814 @default.
- W2134262073 cites W2033971068 @default.
- W2134262073 cites W2038106939 @default.
- W2134262073 cites W2038254125 @default.
- W2134262073 cites W2043042462 @default.
- W2134262073 cites W2044608996 @default.
- W2134262073 cites W2046312189 @default.
- W2134262073 cites W2048850912 @default.
- W2134262073 cites W2051066066 @default.
- W2134262073 cites W2051316797 @default.
- W2134262073 cites W2052172841 @default.
- W2134262073 cites W2056714071 @default.
- W2134262073 cites W2057759890 @default.
- W2134262073 cites W2059175990 @default.
- W2134262073 cites W2059951197 @default.
- W2134262073 cites W2061866900 @default.
- W2134262073 cites W2061912403 @default.
- W2134262073 cites W2064023459 @default.
- W2134262073 cites W2071427720 @default.
- W2134262073 cites W2071817494 @default.
- W2134262073 cites W2072914420 @default.
- W2134262073 cites W2074503465 @default.
- W2134262073 cites W2075607637 @default.
- W2134262073 cites W2076770247 @default.
- W2134262073 cites W2082315732 @default.
- W2134262073 cites W2084897544 @default.
- W2134262073 cites W2086913408 @default.
- W2134262073 cites W2087474170 @default.
- W2134262073 cites W2088363096 @default.
- W2134262073 cites W2096310049 @default.
- W2134262073 cites W2100869656 @default.
- W2134262073 cites W2107425729 @default.
- W2134262073 cites W2108486371 @default.
- W2134262073 cites W2108582916 @default.
- W2134262073 cites W2117456484 @default.
- W2134262073 cites W2122924153 @default.
- W2134262073 cites W2131216996 @default.
- W2134262073 cites W2137333423 @default.
- W2134262073 cites W2150631269 @default.
- W2134262073 cites W2153697948 @default.
- W2134262073 cites W2157993432 @default.
- W2134262073 cites W2164106853 @default.
- W2134262073 cites W2169448152 @default.
- W2134262073 cites W2331156246 @default.
- W2134262073 cites W2398229687 @default.
- W2134262073 cites W2398939307 @default.
- W2134262073 cites W2403975263 @default.
- W2134262073 cites W2405022943 @default.
- W2134262073 cites W2408339784 @default.
- W2134262073 cites W261007879 @default.
- W2134262073 cites W2685401224 @default.
- W2134262073 cites W32931231 @default.