Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134263933> ?p ?o ?g. }
- W2134263933 endingPage "124" @default.
- W2134263933 startingPage "116" @default.
- W2134263933 abstract "Bile duct ligation (BDL) induces primary biliary cirrhosis characterized by cholestasis, impaired liver function and cognition including impairment of memory formation and anxiety-like behaviors. Endogenous opioid and acetylcholine levels are elevated in animal model of cholestasis. In addition, there is no data about the effects of interaction opioidergic and cholinergic systems of dorsal hippocampus (CA1) on amnesia-induced by cholestasis. Male mice weighing 25-35 g were used in this study. Cholestasis was induced by the ligation of the common bile duct. One-trial step-down and hole-board paradigms were used for the assessment of memory retrieval and anxiety-like behaviors respectively. All drugs injected intra-CA1. The data showed that cholestasis (24 days after BDL) decreased memory retrieval. Sole intra-CA1 injection of higher dose of mecamylamine (0.125, 0.25, 0.5 and 1 μg/mice) and scopolamine (0.125, 0.25, 0.5 1 and 2 μg/mice) but not all doses of naloxone (0.0125, 0.025 and 0.05 μg/mice) decreased memory retrieval in the sham operated BDL. The ineffective doses of naloxone (0.025 and 0.05 μg/mice), mecamylamine (0.5 μg/mice) and scopolamine (0.5 μg/mice) restored cholestasis-induced amnesia 24 days after BDL. Further, all cross co-administration ineffective doses of naloxone (0.0125 μg/mice), mecamylamine (0.125 μg/mice) and scopolamine (0.125 μg/mice) reversed cholestasis-induced amnesia. All doses of the drugs have no effect on exploratory behaviors. The data strongly revealed that synergistic effect between opioidergic and cholinergic systems of CA1 on the modulation of cholestasis-induced amnesia." @default.
- W2134263933 created "2016-06-24" @default.
- W2134263933 creator A5004772033 @default.
- W2134263933 creator A5034350764 @default.
- W2134263933 creator A5057884787 @default.
- W2134263933 date "2012-03-01" @default.
- W2134263933 modified "2023-10-01" @default.
- W2134263933 title "Possible interaction between opioidergic and cholinergic systems of CA1 in cholestasis-induced amnesia in mice" @default.
- W2134263933 cites W1527035699 @default.
- W2134263933 cites W1543053652 @default.
- W2134263933 cites W1562709508 @default.
- W2134263933 cites W1896370059 @default.
- W2134263933 cites W1964992763 @default.
- W2134263933 cites W1972883579 @default.
- W2134263933 cites W1973091936 @default.
- W2134263933 cites W1982049192 @default.
- W2134263933 cites W1982503319 @default.
- W2134263933 cites W1986137959 @default.
- W2134263933 cites W1986199494 @default.
- W2134263933 cites W1988878380 @default.
- W2134263933 cites W1989063862 @default.
- W2134263933 cites W1990407144 @default.
- W2134263933 cites W1991127252 @default.
- W2134263933 cites W1991817028 @default.
- W2134263933 cites W1994067502 @default.
- W2134263933 cites W2001059142 @default.
- W2134263933 cites W2002322884 @default.
- W2134263933 cites W2002533951 @default.
- W2134263933 cites W2005215073 @default.
- W2134263933 cites W2006489620 @default.
- W2134263933 cites W2008355571 @default.
- W2134263933 cites W2012130528 @default.
- W2134263933 cites W2017071258 @default.
- W2134263933 cites W2018085133 @default.
- W2134263933 cites W2018434736 @default.
- W2134263933 cites W2020825180 @default.
- W2134263933 cites W2022723969 @default.
- W2134263933 cites W2026676915 @default.
- W2134263933 cites W2027948788 @default.
- W2134263933 cites W2030274035 @default.
- W2134263933 cites W2030369635 @default.
- W2134263933 cites W2030474004 @default.
- W2134263933 cites W2030607172 @default.
- W2134263933 cites W2033236189 @default.
- W2134263933 cites W2035667680 @default.
- W2134263933 cites W2036947369 @default.
- W2134263933 cites W2037297309 @default.
- W2134263933 cites W2037689415 @default.
- W2134263933 cites W2038588996 @default.
- W2134263933 cites W2039398668 @default.
- W2134263933 cites W2039807965 @default.
- W2134263933 cites W2045683730 @default.
- W2134263933 cites W2046118004 @default.
- W2134263933 cites W2046159428 @default.
- W2134263933 cites W2052809998 @default.
- W2134263933 cites W2053703740 @default.
- W2134263933 cites W2054911815 @default.
- W2134263933 cites W2055613228 @default.
- W2134263933 cites W2056262515 @default.
- W2134263933 cites W2060038083 @default.
- W2134263933 cites W2062832205 @default.
- W2134263933 cites W2064889561 @default.
- W2134263933 cites W2065400400 @default.
- W2134263933 cites W2065788111 @default.
- W2134263933 cites W2066027939 @default.
- W2134263933 cites W2070380898 @default.
- W2134263933 cites W2074311381 @default.
- W2134263933 cites W2074896885 @default.
- W2134263933 cites W2076161202 @default.
- W2134263933 cites W2077928619 @default.
- W2134263933 cites W2080457192 @default.
- W2134263933 cites W2080784536 @default.
- W2134263933 cites W2083648263 @default.
- W2134263933 cites W2083996865 @default.
- W2134263933 cites W2084001480 @default.
- W2134263933 cites W2089153423 @default.
- W2134263933 cites W2089468617 @default.
- W2134263933 cites W2090699918 @default.
- W2134263933 cites W2107557961 @default.
- W2134263933 cites W2116406527 @default.
- W2134263933 cites W2118112683 @default.
- W2134263933 cites W2131898932 @default.
- W2134263933 cites W2135623413 @default.
- W2134263933 cites W2138885654 @default.
- W2134263933 cites W2142874269 @default.
- W2134263933 cites W2154360214 @default.
- W2134263933 cites W2162653297 @default.
- W2134263933 cites W2162870648 @default.
- W2134263933 cites W2168660234 @default.
- W2134263933 cites W2228573 @default.
- W2134263933 cites W4239133134 @default.
- W2134263933 doi "https://doi.org/10.1016/j.bbr.2011.11.039" @default.
- W2134263933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22155612" @default.
- W2134263933 hasPublicationYear "2012" @default.
- W2134263933 type Work @default.
- W2134263933 sameAs 2134263933 @default.
- W2134263933 citedByCount "30" @default.
- W2134263933 countsByYear W21342639332013 @default.