Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134264179> ?p ?o ?g. }
- W2134264179 endingPage "e99603" @default.
- W2134264179 startingPage "e99603" @default.
- W2134264179 abstract "MBD2 is a subunit of the NuRD complex that is postulated to mediate gene repression via recruitment of the complex to methylated DNA. In this study we adopted an MBD2 tagging-approach to study its genome wide binding characteristics. We show that in vivo MBD2 is mainly recruited to CpG island promoters that are highly methylated. Interestingly, MBD2 binds around 1 kb downstream of the transcription start site of a subset of ∼400 CpG island promoters that are characterized by the presence of active histone marks, RNA polymerase II (Pol2) and low to medium gene expression levels and H3K36me3 deposition. These tagged-MBD2 binding sites in MCF-7 show increased methylation in a cohort of primary breast cancers but not in normal breast samples, suggesting a putative role for MBD2 in breast cancer." @default.
- W2134264179 created "2016-06-24" @default.
- W2134264179 creator A5003643990 @default.
- W2134264179 creator A5007026827 @default.
- W2134264179 creator A5013073310 @default.
- W2134264179 creator A5016029531 @default.
- W2134264179 creator A5017169522 @default.
- W2134264179 creator A5020365483 @default.
- W2134264179 creator A5036095832 @default.
- W2134264179 creator A5036890213 @default.
- W2134264179 creator A5076632696 @default.
- W2134264179 creator A5079581490 @default.
- W2134264179 date "2014-06-13" @default.
- W2134264179 modified "2023-09-29" @default.
- W2134264179 title "Genome-Wide Binding of MBD2 Reveals Strong Preference for Highly Methylated Loci" @default.
- W2134264179 cites W131564386 @default.
- W2134264179 cites W1504303645 @default.
- W2134264179 cites W1519629411 @default.
- W2134264179 cites W1609534144 @default.
- W2134264179 cites W1974747095 @default.
- W2134264179 cites W1984077980 @default.
- W2134264179 cites W1994302320 @default.
- W2134264179 cites W1998697112 @default.
- W2134264179 cites W2000519327 @default.
- W2134264179 cites W2014817033 @default.
- W2134264179 cites W2014852291 @default.
- W2134264179 cites W2018758172 @default.
- W2134264179 cites W2019769511 @default.
- W2134264179 cites W2020138426 @default.
- W2134264179 cites W2020702702 @default.
- W2134264179 cites W2020813502 @default.
- W2134264179 cites W2026501344 @default.
- W2134264179 cites W2030513330 @default.
- W2134264179 cites W2037848370 @default.
- W2134264179 cites W2038894647 @default.
- W2134264179 cites W2051793286 @default.
- W2134264179 cites W2051966279 @default.
- W2134264179 cites W2059041864 @default.
- W2134264179 cites W2071154937 @default.
- W2134264179 cites W2075748627 @default.
- W2134264179 cites W2080752012 @default.
- W2134264179 cites W2084118479 @default.
- W2134264179 cites W2084634691 @default.
- W2134264179 cites W2093146349 @default.
- W2134264179 cites W2099343472 @default.
- W2134264179 cites W2100649212 @default.
- W2134264179 cites W2101177010 @default.
- W2134264179 cites W2108549889 @default.
- W2134264179 cites W2111893274 @default.
- W2134264179 cites W2114912562 @default.
- W2134264179 cites W2133619594 @default.
- W2134264179 cites W2141395565 @default.
- W2134264179 cites W2152497434 @default.
- W2134264179 cites W2153900602 @default.
- W2134264179 cites W2155563035 @default.
- W2134264179 cites W2158997389 @default.
- W2134264179 doi "https://doi.org/10.1371/journal.pone.0099603" @default.
- W2134264179 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4057170" @default.
- W2134264179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24927503" @default.
- W2134264179 hasPublicationYear "2014" @default.
- W2134264179 type Work @default.
- W2134264179 sameAs 2134264179 @default.
- W2134264179 citedByCount "45" @default.
- W2134264179 countsByYear W21342641792014 @default.
- W2134264179 countsByYear W21342641792015 @default.
- W2134264179 countsByYear W21342641792016 @default.
- W2134264179 countsByYear W21342641792017 @default.
- W2134264179 countsByYear W21342641792018 @default.
- W2134264179 countsByYear W21342641792019 @default.
- W2134264179 countsByYear W21342641792020 @default.
- W2134264179 countsByYear W21342641792021 @default.
- W2134264179 countsByYear W21342641792022 @default.
- W2134264179 countsByYear W21342641792023 @default.
- W2134264179 crossrefType "journal-article" @default.
- W2134264179 hasAuthorship W2134264179A5003643990 @default.
- W2134264179 hasAuthorship W2134264179A5007026827 @default.
- W2134264179 hasAuthorship W2134264179A5013073310 @default.
- W2134264179 hasAuthorship W2134264179A5016029531 @default.
- W2134264179 hasAuthorship W2134264179A5017169522 @default.
- W2134264179 hasAuthorship W2134264179A5020365483 @default.
- W2134264179 hasAuthorship W2134264179A5036095832 @default.
- W2134264179 hasAuthorship W2134264179A5036890213 @default.
- W2134264179 hasAuthorship W2134264179A5076632696 @default.
- W2134264179 hasAuthorship W2134264179A5079581490 @default.
- W2134264179 hasBestOaLocation W21342641791 @default.
- W2134264179 hasConcept C101762097 @default.
- W2134264179 hasConcept C104317684 @default.
- W2134264179 hasConcept C140173407 @default.
- W2134264179 hasConcept C150194340 @default.
- W2134264179 hasConcept C153911025 @default.
- W2134264179 hasConcept C154253233 @default.
- W2134264179 hasConcept C165864922 @default.
- W2134264179 hasConcept C190727270 @default.
- W2134264179 hasConcept C33288867 @default.
- W2134264179 hasConcept C37080517 @default.
- W2134264179 hasConcept C41091548 @default.
- W2134264179 hasConcept C54355233 @default.
- W2134264179 hasConcept C64927066 @default.