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- W2134266760 endingPage "2933" @default.
- W2134266760 startingPage "2919" @default.
- W2134266760 abstract "ABSTRACT Transcription factors can function as DNA-binding-specific activators or as coactivators. c-Jun drives gene expression via binding to AP-1 sequences or as a cofactor for PU.1 in macrophages. c-Jun heterodimers bind AP-1 sequences with higher affinity than homodimers, but how c-Jun works as a coactivator is unknown. Here, we provide in vitro and in vivo evidence that c-Jun homodimers are recruited to the interleukin-1β (IL-1β) promoter in the absence of direct DNA binding via protein-protein interactions with DNA-anchored PU.1 and CCAAT/enhancer-binding protein β (C/EBPβ). Unexpectedly, the interaction interface with PU.1 and C/EBPβ involves four of the residues within the basic domain of c-Jun that contact DNA, indicating that the capacities of c-Jun to function as a coactivator or as a DNA-bound transcription factor are mutually exclusive. Our observations indicate that the IL-1β locus is occupied by PU.1 and C/EBPβ and poised for expression and that c-Jun enhances transcription by facilitating a rate-limiting step, the assembly of the RNA polymerase II preinitiation complex, with minimal effect on the local chromatin status. We propose that the basic domain of other transcription factors may also be redirected from a DNA interaction mode to a protein-protein interaction mode and that this switch represents a novel mechanism regulating gene expression profiles." @default.
- W2134266760 created "2016-06-24" @default.
- W2134266760 creator A5013670640 @default.
- W2134266760 creator A5026935414 @default.
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- W2134266760 creator A5069621309 @default.
- W2134266760 creator A5071737028 @default.
- W2134266760 creator A5076143416 @default.
- W2134266760 date "2007-04-15" @default.
- W2134266760 modified "2023-10-18" @default.
- W2134266760 title "c-Jun Homodimers Can Function as a Context-Specific Coactivator" @default.
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