FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134266932> ?p ?o ?g. }

• W2134266932 endingPage "1449" @default.
• W2134266932 startingPage "1436" @default.
• W2134266932 abstract "The spread of cancer cells from a primary tumor to form metastasis at distant sites is a complex multistep process. The cancer cell proteins and plasma membrane proteins in particular involved in this process are poorly defined, and a study of the very early events of the metastatic process using clinical samples or in vitro assays is not feasible. We have used a unique model system consisting of two isogenic human breast cancer cell lines that are equally tumorigenic in mice; but although one gives rise to metastasis, the other disseminates single cells that remain dormant at distant organs. Membrane purification and comparative quantitative LC-MS/MS proteomics identified 13 membrane proteins that were expressed at higher levels and three that were underexpressed in the metastatic compared with the non-metastatic cell line from a total of 1919 identified protein entries. Among the proteins were ecto-5'-nucleotidase (CD73), NDRG1, integrin beta1, CD44, CD74, and major histocompatibility complex class II proteins. The altered expression levels of proteins identified by LC-MS/MS were validated using flow cytometry, Western blotting, and immunocyto- and immunohistochemistry. Analysis of clinical breast cancer biopsies demonstrated a significant correlation between high ecto-5'-nucleotidase and integrin beta1 expression and poor outcome, measured as tumor spread or distant recurrence within a 10-year follow-up. Further the tissue analysis suggested that NDRG1, HLA-DRalpha, HLA-DRbeta, and CD74 were associated with the ER(-)/PR(-) phenotype represented by the two cell lines. The study demonstrates a quantitative and comparative proteomics strategy to identify clinically relevant key molecules in the early events of metastasis, some of which may prove to be potential targets for cancer therapy." @default.
• W2134266932 created "2016-06-24" @default.
• W2134266932 creator A5011278913 @default.
• W2134266932 creator A5011720560 @default.
• W2134266932 creator A5030600960 @default.
• W2134266932 creator A5040297156 @default.
• W2134266932 creator A5054557695 @default.
• W2134266932 creator A5065061153 @default.
• W2134266932 creator A5090124815 @default.
• W2134266932 date "2009-06-01" @default.
• W2134266932 modified "2023-10-11" @default.
• W2134266932 title "Metastasis-related Plasma Membrane Proteins of Human Breast Cancer Cells Identified by Comparative Quantitative Mass Spectrometry" @default.
• W2134266932 cites W1480706413 @default.
• W2134266932 cites W1734622341 @default.
• W2134266932 cites W1971272821 @default.
• W2134266932 cites W1977648783 @default.
• W2134266932 cites W1980757374 @default.
• W2134266932 cites W1986175756 @default.
• W2134266932 cites W2004280628 @default.
• W2134266932 cites W2004626510 @default.
• W2134266932 cites W2005310013 @default.
• W2134266932 cites W2005616665 @default.
• W2134266932 cites W2014322220 @default.
• W2134266932 cites W2017407272 @default.
• W2134266932 cites W2017470267 @default.
• W2134266932 cites W2019520753 @default.
• W2134266932 cites W2020830322 @default.
• W2134266932 cites W2021951737 @default.
• W2134266932 cites W2029548767 @default.
• W2134266932 cites W2031164152 @default.
• W2134266932 cites W2037100155 @default.
• W2134266932 cites W2040598177 @default.
• W2134266932 cites W2043576499 @default.
• W2134266932 cites W2044748653 @default.
• W2134266932 cites W2049570902 @default.
• W2134266932 cites W2051795211 @default.
• W2134266932 cites W2051881409 @default.
• W2134266932 cites W2060691656 @default.
• W2134266932 cites W2060955755 @default.
• W2134266932 cites W2073155340 @default.
• W2134266932 cites W2073222527 @default.
• W2134266932 cites W2074378720 @default.
• W2134266932 cites W2076063336 @default.
• W2134266932 cites W2076364581 @default.
• W2134266932 cites W2087441379 @default.
• W2134266932 cites W2090399120 @default.
• W2134266932 cites W2091681446 @default.
• W2134266932 cites W2093477167 @default.
• W2134266932 cites W2096881051 @default.
• W2134266932 cites W2099102308 @default.
• W2134266932 cites W2100197230 @default.
• W2134266932 cites W2103004412 @default.
• W2134266932 cites W2104047381 @default.
• W2134266932 cites W2109276980 @default.
• W2134266932 cites W2115371966 @default.
• W2134266932 cites W2117100825 @default.
• W2134266932 cites W2120805495 @default.
• W2134266932 cites W2128674875 @default.
• W2134266932 cites W2138022504 @default.
• W2134266932 cites W2140395194 @default.
• W2134266932 cites W2140946052 @default.
• W2134266932 cites W2143092252 @default.
• W2134266932 cites W2155366350 @default.
• W2134266932 cites W2169402489 @default.
• W2134266932 cites W2324512064 @default.
• W2134266932 cites W4213141530 @default.
• W2134266932 cites W44920436 @default.
• W2134266932 cites W94505367 @default.
• W2134266932 doi "https://doi.org/10.1074/mcp.m800061-mcp200" @default.
• W2134266932 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2690497" @default.
• W2134266932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19321434" @default.
• W2134266932 hasPublicationYear "2009" @default.
• W2134266932 type Work @default.
• W2134266932 sameAs 2134266932 @default.
• W2134266932 citedByCount "111" @default.
• W2134266932 countsByYear W21342669322012 @default.
• W2134266932 countsByYear W21342669322013 @default.
• W2134266932 countsByYear W21342669322014 @default.
• W2134266932 countsByYear W21342669322015 @default.
• W2134266932 countsByYear W21342669322016 @default.
• W2134266932 countsByYear W21342669322017 @default.
• W2134266932 countsByYear W21342669322018 @default.
• W2134266932 countsByYear W21342669322019 @default.
• W2134266932 countsByYear W21342669322020 @default.
• W2134266932 countsByYear W21342669322021 @default.
• W2134266932 countsByYear W21342669322022 @default.
• W2134266932 countsByYear W21342669322023 @default.
• W2134266932 crossrefType "journal-article" @default.
• W2134266932 hasAuthorship W2134266932A5011278913 @default.
• W2134266932 hasAuthorship W2134266932A5011720560 @default.
• W2134266932 hasAuthorship W2134266932A5030600960 @default.
• W2134266932 hasAuthorship W2134266932A5040297156 @default.
• W2134266932 hasAuthorship W2134266932A5054557695 @default.
• W2134266932 hasAuthorship W2134266932A5065061153 @default.
• W2134266932 hasAuthorship W2134266932A5090124815 @default.
• W2134266932 hasBestOaLocation W21342669321 @default.
• W2134266932 hasConcept C104317684 @default.
• W2134266932 hasConcept C121608353 @default.

• next