Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134268006> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2134268006 endingPage "361" @default.
- W2134268006 startingPage "358" @default.
- W2134268006 abstract "ABSTRACT While CD4 cell counts are widely used to predict disease progression in human immunodeficiency virus (HIV)-infected patients, they are poorly explanatory of the progression to AIDS or death after the introduction of chemotherapy. Changes in HIV load (as measured by RNA PCR) have been shown to be a much better predictor of the risk of disease progression. Since the interrelationship of these markers is of great clinical interest, we modeled the time-averaged return of CD4 cell count and change in viral load subsequent to therapy with the HIV protease inhibitor indinavir. We found that CD4 cell return was significantly related to both the baseline CD4 count ( r 2 = 0.86, P < 0.001) and the decline in HIV RNA PCR-determined viral load (also referred to in this work as the HIV RNA PCR decline) ( r 2 = 0.60, P < 0.01). Simultaneously modeling both influences in a linked nonlinear model ( r 2 = 0.93, P < 0.001) demonstrated that (i) the starting number of CD4 cells accounted for the majority of the change in CD4 cell return and (ii) the return of CD4 cells attributable to viral load decrease was 50% of maximal with only a decrease of approximately 0.2 log of HIV RNA as modeled from the first 12 weeks of therapy. Much greater viral inhibition beyond that necessary for maximal CD4 cell return is possible. Given that HIV RNA PCR decline is more strongly linked to ultimate clinical course in HIV disease, our findings indicate that CD4 return is potentially misleading as an indicator of antiviral effect, since it is determined more by the starting CD4 value than by viral load decline and since near-maximal changes occur with minimal antiviral effect." @default.
- W2134268006 created "2016-06-24" @default.
- W2134268006 creator A5036512885 @default.
- W2134268006 creator A5082899242 @default.
- W2134268006 date "1998-02-01" @default.
- W2134268006 modified "2023-09-23" @default.
- W2134268006 title "Mathematical Modeling of the Interrelationship of CD4 Lymphocyte Count and Viral Load Changes Induced by the Protease Inhibitor Indinavir" @default.
- W2134268006 cites W1561141774 @default.
- W2134268006 cites W1973398091 @default.
- W2134268006 cites W1980167636 @default.
- W2134268006 cites W1988763067 @default.
- W2134268006 cites W2009226722 @default.
- W2134268006 cites W2011630381 @default.
- W2134268006 cites W2012139740 @default.
- W2134268006 cites W2043467964 @default.
- W2134268006 cites W2054620412 @default.
- W2134268006 cites W2065608903 @default.
- W2134268006 cites W2078326422 @default.
- W2134268006 cites W2080314044 @default.
- W2134268006 cites W2099352670 @default.
- W2134268006 cites W2150202027 @default.
- W2134268006 cites W2150985908 @default.
- W2134268006 cites W2330207218 @default.
- W2134268006 cites W2340851790 @default.
- W2134268006 cites W4235858801 @default.
- W2134268006 doi "https://doi.org/10.1128/aac.42.2.358" @default.
- W2134268006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/105414" @default.
- W2134268006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9527786" @default.
- W2134268006 hasPublicationYear "1998" @default.
- W2134268006 type Work @default.
- W2134268006 sameAs 2134268006 @default.
- W2134268006 citedByCount "16" @default.
- W2134268006 countsByYear W21342680062014 @default.
- W2134268006 crossrefType "journal-article" @default.
- W2134268006 hasAuthorship W2134268006A5036512885 @default.
- W2134268006 hasAuthorship W2134268006A5082899242 @default.
- W2134268006 hasBestOaLocation W21342680061 @default.
- W2134268006 hasConcept C104317684 @default.
- W2134268006 hasConcept C126322002 @default.
- W2134268006 hasConcept C142462285 @default.
- W2134268006 hasConcept C159047783 @default.
- W2134268006 hasConcept C203014093 @default.
- W2134268006 hasConcept C2522874641 @default.
- W2134268006 hasConcept C2777210460 @default.
- W2134268006 hasConcept C2777761686 @default.
- W2134268006 hasConcept C2779690655 @default.
- W2134268006 hasConcept C2780727368 @default.
- W2134268006 hasConcept C2781143361 @default.
- W2134268006 hasConcept C2993143319 @default.
- W2134268006 hasConcept C54355233 @default.
- W2134268006 hasConcept C67705224 @default.
- W2134268006 hasConcept C71924100 @default.
- W2134268006 hasConcept C86803240 @default.
- W2134268006 hasConceptScore W2134268006C104317684 @default.
- W2134268006 hasConceptScore W2134268006C126322002 @default.
- W2134268006 hasConceptScore W2134268006C142462285 @default.
- W2134268006 hasConceptScore W2134268006C159047783 @default.
- W2134268006 hasConceptScore W2134268006C203014093 @default.
- W2134268006 hasConceptScore W2134268006C2522874641 @default.
- W2134268006 hasConceptScore W2134268006C2777210460 @default.
- W2134268006 hasConceptScore W2134268006C2777761686 @default.
- W2134268006 hasConceptScore W2134268006C2779690655 @default.
- W2134268006 hasConceptScore W2134268006C2780727368 @default.
- W2134268006 hasConceptScore W2134268006C2781143361 @default.
- W2134268006 hasConceptScore W2134268006C2993143319 @default.
- W2134268006 hasConceptScore W2134268006C54355233 @default.
- W2134268006 hasConceptScore W2134268006C67705224 @default.
- W2134268006 hasConceptScore W2134268006C71924100 @default.
- W2134268006 hasConceptScore W2134268006C86803240 @default.
- W2134268006 hasIssue "2" @default.
- W2134268006 hasLocation W21342680061 @default.
- W2134268006 hasLocation W21342680062 @default.
- W2134268006 hasOpenAccess W2134268006 @default.
- W2134268006 hasPrimaryLocation W21342680061 @default.
- W2134268006 hasRelatedWork W2046593269 @default.
- W2134268006 hasRelatedWork W2057744966 @default.
- W2134268006 hasRelatedWork W2070504323 @default.
- W2134268006 hasRelatedWork W2077563405 @default.
- W2134268006 hasRelatedWork W2090838386 @default.
- W2134268006 hasRelatedWork W2134268006 @default.
- W2134268006 hasRelatedWork W2321170269 @default.
- W2134268006 hasRelatedWork W2440945077 @default.
- W2134268006 hasRelatedWork W64494153 @default.
- W2134268006 hasRelatedWork W1993314454 @default.
- W2134268006 hasVolume "42" @default.
- W2134268006 isParatext "false" @default.
- W2134268006 isRetracted "false" @default.
- W2134268006 magId "2134268006" @default.
- W2134268006 workType "article" @default.