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- W2134268412 abstract "Inspired by biologically active natural products, a hybrid analogue that combines the N-Me urocanic side chain of the sarcodictyin family of compounds with the chalcone motif has been proposed, synthesised and examined for antiproliferative activity in three cancer cell lines and one normal primary cell line. The analogues are all synthesised in one or two steps from commercially available materials and, of the compounds examined, the proposed hybrid analogue displays the most active and selective inhibition of cell proliferation in human colon cancer cell line HT29 (IC50 2.9 μM) and highly metastatic human breast carcinoma MDA-MB-231 (IC50 4.8 μM)." @default.
- W2134268412 created "2016-06-24" @default.
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- W2134268412 date "2011-01-01" @default.
- W2134268412 modified "2023-09-25" @default.
- W2134268412 title "Design, synthesis and antiproliferative activity of urocanic-chalcone hybrid derivatives" @default.
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- W2134268412 doi "https://doi.org/10.1039/c1md00155h" @default.
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