Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134295752> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2134295752 abstract "Formaldehyde is commonly used in the chemical industry and is present in the environment, such as vehicle emissions, some building materials, food and tobacco smoke. It also occurs as a natural product in most organisms, the sources of which include a number of metabolic processes. It causes various acute and chronic adverse effects in humans if they inhale its fumes. Among the chronic effects on human health, we summarize data on genotoxicity and carcinogenicity in this review, and we particularly focus on the molecular mechanisms involved in the formaldehyde mutagenesis. Formaldehyde mainly induces N-hydroxymethyl mono-adducts on guanine, adenine and cytosine, and N-methylene crosslinks between adjacent purines in DNA. These crosslinks are types of DNA damage potentially fatal for cell survival if they are not removed by the nucleotide excision repair pathway. In the previous studies, we showed evidence that formaldehyde causes intra-strand crosslinks between purines in DNA using a unique method (Matsuda et al. Nucleic Acids Res. 26, 1769-1774,1998). Using shuttle vector plasmids, we also showed that formaldehyde as well as acetaldehyde induces tandem base substitutions, mainly at 5’-GG and 5’-GA sequences, which would arise from the intra-strand crosslinks. These mutation features are different from those of other aldehydes such as crotonaldehyde, acrolein, glyoxal and methylglyoxal. These findings provide molecular clues to improve our understanding of the genotoxicity and carcinogenicity of formaldehyde." @default.
- W2134295752 created "2016-06-24" @default.
- W2134295752 creator A5047468314 @default.
- W2134295752 creator A5052984027 @default.
- W2134295752 creator A5053280611 @default.
- W2134295752 date "2014-09-16" @default.
- W2134295752 modified "2023-10-16" @default.
- W2134295752 title "Genotoxicity of formaldehyde: molecular basis of DNA damage and mutation" @default.
- W2134295752 cites W1970583034 @default.
- W2134295752 cites W1983608968 @default.
- W2134295752 cites W1996952563 @default.
- W2134295752 cites W2000026888 @default.
- W2134295752 cites W2016019039 @default.
- W2134295752 cites W2024912078 @default.
- W2134295752 cites W2041135922 @default.
- W2134295752 cites W2064668348 @default.
- W2134295752 cites W2065251416 @default.
- W2134295752 cites W2093488683 @default.
- W2134295752 cites W2097731514 @default.
- W2134295752 cites W2116678462 @default.
- W2134295752 cites W2136393874 @default.
- W2134295752 cites W2142382772 @default.
- W2134295752 cites W2145063914 @default.
- W2134295752 cites W2148390052 @default.
- W2134295752 cites W2153670806 @default.
- W2134295752 cites W2159720596 @default.
- W2134295752 cites W2169882112 @default.
- W2134295752 cites W4237570497 @default.
- W2134295752 doi "https://doi.org/10.3389/fenvs.2014.00036" @default.
- W2134295752 hasPublicationYear "2014" @default.
- W2134295752 type Work @default.
- W2134295752 sameAs 2134295752 @default.
- W2134295752 citedByCount "53" @default.
- W2134295752 countsByYear W21342957522016 @default.
- W2134295752 countsByYear W21342957522017 @default.
- W2134295752 countsByYear W21342957522018 @default.
- W2134295752 countsByYear W21342957522019 @default.
- W2134295752 countsByYear W21342957522020 @default.
- W2134295752 countsByYear W21342957522021 @default.
- W2134295752 countsByYear W21342957522022 @default.
- W2134295752 countsByYear W21342957522023 @default.
- W2134295752 crossrefType "journal-article" @default.
- W2134295752 hasAuthorship W2134295752A5047468314 @default.
- W2134295752 hasAuthorship W2134295752A5052984027 @default.
- W2134295752 hasAuthorship W2134295752A5053280611 @default.
- W2134295752 hasBestOaLocation W21342957521 @default.
- W2134295752 hasConcept C104317684 @default.
- W2134295752 hasConcept C143425029 @default.
- W2134295752 hasConcept C178790620 @default.
- W2134295752 hasConcept C185592680 @default.
- W2134295752 hasConcept C2775930285 @default.
- W2134295752 hasConcept C2778959862 @default.
- W2134295752 hasConcept C2780358455 @default.
- W2134295752 hasConcept C29730261 @default.
- W2134295752 hasConcept C501734568 @default.
- W2134295752 hasConcept C54355233 @default.
- W2134295752 hasConcept C552990157 @default.
- W2134295752 hasConcept C55493867 @default.
- W2134295752 hasConcept C86803240 @default.
- W2134295752 hasConceptScore W2134295752C104317684 @default.
- W2134295752 hasConceptScore W2134295752C143425029 @default.
- W2134295752 hasConceptScore W2134295752C178790620 @default.
- W2134295752 hasConceptScore W2134295752C185592680 @default.
- W2134295752 hasConceptScore W2134295752C2775930285 @default.
- W2134295752 hasConceptScore W2134295752C2778959862 @default.
- W2134295752 hasConceptScore W2134295752C2780358455 @default.
- W2134295752 hasConceptScore W2134295752C29730261 @default.
- W2134295752 hasConceptScore W2134295752C501734568 @default.
- W2134295752 hasConceptScore W2134295752C54355233 @default.
- W2134295752 hasConceptScore W2134295752C552990157 @default.
- W2134295752 hasConceptScore W2134295752C55493867 @default.
- W2134295752 hasConceptScore W2134295752C86803240 @default.
- W2134295752 hasLocation W21342957521 @default.
- W2134295752 hasLocation W21342957522 @default.
- W2134295752 hasOpenAccess W2134295752 @default.
- W2134295752 hasPrimaryLocation W21342957521 @default.
- W2134295752 hasRelatedWork W1985401126 @default.
- W2134295752 hasRelatedWork W2008732778 @default.
- W2134295752 hasRelatedWork W2082617406 @default.
- W2134295752 hasRelatedWork W2108783659 @default.
- W2134295752 hasRelatedWork W2111916114 @default.
- W2134295752 hasRelatedWork W2125435889 @default.
- W2134295752 hasRelatedWork W2209591937 @default.
- W2134295752 hasRelatedWork W2327748090 @default.
- W2134295752 hasRelatedWork W2574549984 @default.
- W2134295752 hasRelatedWork W2582733893 @default.
- W2134295752 hasVolume "2" @default.
- W2134295752 isParatext "false" @default.
- W2134295752 isRetracted "false" @default.
- W2134295752 magId "2134295752" @default.
- W2134295752 workType "article" @default.