Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134299128> ?p ?o ?g. }
- W2134299128 endingPage "1723" @default.
- W2134299128 startingPage "1713" @default.
- W2134299128 abstract "The expression of beta-catenin, a potent oncogene, is causally linked to tumorigenesis. Therefore, it was surprising that the transgenic expression of oncogenic beta-catenin in thymocytes resulted in thymic involution instead of lymphomagenesis. In this report, we demonstrate that this is because the expression of oncogenic beta-catenin induces DNA damage, growth arrest, oncogene-induced senescence (OIS), and apoptosis of immature thymocytes. In p53-deficient mice, the expression of oncogenic beta-catenin still results in DNA damage and OIS, but the thymocytes survive and eventually progress to thymic lymphoma. beta-Catenin-induced thymic lymphomas are distinct from lymphomas that arise in p53(-/-) mice. They are CD4(-) CD8(-), while p53-dependent lymphomas are largely CD4(+) CD8(+), and they develop at an earlier age and in the absence of c-Myc expression or Notch1 signaling. Thus, we report that oncogenic beta-catenin-induced, p53-independent growth arrest and OIS and p53-dependent apoptosis protect developing thymocytes from transformation by oncogenic beta-catenin." @default.
- W2134299128 created "2016-06-24" @default.
- W2134299128 creator A5000208362 @default.
- W2134299128 creator A5018097630 @default.
- W2134299128 creator A5031392514 @default.
- W2134299128 creator A5051546133 @default.
- W2134299128 creator A5073724356 @default.
- W2134299128 creator A5086282793 @default.
- W2134299128 date "2008-03-01" @default.
- W2134299128 modified "2023-10-10" @default.
- W2134299128 title "β-Catenin Expression Results in p53-Independent DNA Damage and Oncogene-Induced Senescence in Prelymphomagenic Thymocytes In Vivo" @default.
- W2134299128 cites W1507615319 @default.
- W2134299128 cites W1554815317 @default.
- W2134299128 cites W1668774261 @default.
- W2134299128 cites W1887190473 @default.
- W2134299128 cites W196512513 @default.
- W2134299128 cites W1969222622 @default.
- W2134299128 cites W1978686705 @default.
- W2134299128 cites W1980344438 @default.
- W2134299128 cites W1982395176 @default.
- W2134299128 cites W1985234929 @default.
- W2134299128 cites W1989456936 @default.
- W2134299128 cites W1990427876 @default.
- W2134299128 cites W1990768206 @default.
- W2134299128 cites W1993748871 @default.
- W2134299128 cites W1994617139 @default.
- W2134299128 cites W2000506742 @default.
- W2134299128 cites W2001748204 @default.
- W2134299128 cites W2002404925 @default.
- W2134299128 cites W2003930763 @default.
- W2134299128 cites W2004393209 @default.
- W2134299128 cites W2005150833 @default.
- W2134299128 cites W2008887283 @default.
- W2134299128 cites W2019215636 @default.
- W2134299128 cites W2020440343 @default.
- W2134299128 cites W2039534663 @default.
- W2134299128 cites W2039704215 @default.
- W2134299128 cites W2041156660 @default.
- W2134299128 cites W2041888069 @default.
- W2134299128 cites W2043880243 @default.
- W2134299128 cites W2044174672 @default.
- W2134299128 cites W2045264627 @default.
- W2134299128 cites W2050222325 @default.
- W2134299128 cites W2060400485 @default.
- W2134299128 cites W2062019225 @default.
- W2134299128 cites W2063992695 @default.
- W2134299128 cites W2067117191 @default.
- W2134299128 cites W2070537681 @default.
- W2134299128 cites W2075318195 @default.
- W2134299128 cites W2077342759 @default.
- W2134299128 cites W2078172132 @default.
- W2134299128 cites W2080152855 @default.
- W2134299128 cites W2080769506 @default.
- W2134299128 cites W2084969545 @default.
- W2134299128 cites W2086267296 @default.
- W2134299128 cites W2087404852 @default.
- W2134299128 cites W2090863421 @default.
- W2134299128 cites W2093531978 @default.
- W2134299128 cites W2094111999 @default.
- W2134299128 cites W2094633951 @default.
- W2134299128 cites W2099240520 @default.
- W2134299128 cites W2100557384 @default.
- W2134299128 cites W2102618729 @default.
- W2134299128 cites W2103235451 @default.
- W2134299128 cites W2104908670 @default.
- W2134299128 cites W2110508317 @default.
- W2134299128 cites W2114592618 @default.
- W2134299128 cites W2117912210 @default.
- W2134299128 cites W2118453722 @default.
- W2134299128 cites W2121371748 @default.
- W2134299128 cites W2129713447 @default.
- W2134299128 cites W2133291090 @default.
- W2134299128 cites W2149063792 @default.
- W2134299128 cites W2150740687 @default.
- W2134299128 cites W2154054797 @default.
- W2134299128 cites W2155787137 @default.
- W2134299128 cites W2166958955 @default.
- W2134299128 cites W2172228770 @default.
- W2134299128 cites W2239090104 @default.
- W2134299128 doi "https://doi.org/10.1128/mcb.01360-07" @default.
- W2134299128 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2258783" @default.
- W2134299128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18160717" @default.
- W2134299128 hasPublicationYear "2008" @default.
- W2134299128 type Work @default.
- W2134299128 sameAs 2134299128 @default.
- W2134299128 citedByCount "68" @default.
- W2134299128 countsByYear W21342991282012 @default.
- W2134299128 countsByYear W21342991282013 @default.
- W2134299128 countsByYear W21342991282014 @default.
- W2134299128 countsByYear W21342991282015 @default.
- W2134299128 countsByYear W21342991282016 @default.
- W2134299128 countsByYear W21342991282017 @default.
- W2134299128 countsByYear W21342991282018 @default.
- W2134299128 countsByYear W21342991282019 @default.
- W2134299128 countsByYear W21342991282021 @default.
- W2134299128 countsByYear W21342991282022 @default.
- W2134299128 countsByYear W21342991282023 @default.
- W2134299128 crossrefType "journal-article" @default.