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- W2134311596 abstract "BACKGROUND: All-trans-retinol was the first vitamin to be synthesized in the laboratory. Dermatologic research with this agent, first begun in the 1960s, was discontinued because of its instability. Investigations since then have focused primarily on a metabolite of vitamin A, all trans-retinoic acid, for the treatment of various dermatological disorders. TREATMENT: While topically applied retinoic acid is effective in reducing the signs of intrinsic aging and repairing photodamaged skin, depending on the concentration it causes a number of irritant effects, including erythema, peeling, dryness, and pruritus in some patients. This drawback stimulated renewed efforts to find a less irritating retinoid. ADVANCES: As a result of advances in the cosmetic industry, retinol is now being produced in a stable formulation, and is again commanding the attention of investigators. CONCLUSION: Clinical trials conducted so far indicate that, like retinoic acid, retinol can induce changes that have a beneficial effect on the epidermis but with decreased irritation. (J Dermatol Treat (2000) 11:47–52)" @default.
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- W2134311596 date "2000-01-01" @default.
- W2134311596 modified "2023-09-28" @default.
- W2134311596 title "Re-emergence of topical retinol in dermatology" @default.
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- W2134311596 doi "https://doi.org/10.1080/09546630050517685" @default.
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