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- W2134326420 abstract "Elevated plasma homocysteine (Hcy) has been reported in patients with Parkinson disease (PD) treated with levodopa (LD) and is a risk factor for vascular disease and dementia.1 Plasma Hcy levels in patients with PD treated with LD are thought to be elevated by increased synthesis from the metabolism of LD by catechol-O-methyltransferase (COMT). An animal study has demonstrated that pretreatment with a COMT inhibitor can block the elevation of plasma Hcy levels when LD is given.2 These findings suggest that a COMT inhibitor, such as entacapone, may be able to block the elevation of plasma Hcy levels in patients with PD treated with LD. In the current study, we assessed the influence of entacapone on plasma Hcy levels in patients previously treated with LD alone.Subjects were selected from a group of patients participating in the Stalevo (carbidopa/levodopa/entacapone) Study (CELC200US02) designed to assess the tolerability of switching from LD to carbidopa/levodopa/entacapone. The study was …" @default.
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- W2134326420 date "2005-04-25" @default.
- W2134326420 modified "2023-09-24" @default.
- W2134326420 title "The effect of entacapone on homocysteine levels in Parkinson disease" @default.
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- W2134326420 doi "https://doi.org/10.1212/01.wnl.0000158674.91134.6e" @default.
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