FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134332397> ?p ?o ?g. }

• W2134332397 endingPage "699" @default.
• W2134332397 startingPage "690" @default.
• W2134332397 abstract "Xiaoyaosan (XYS), a famous Chinese prescription, composed of Radix Bupleuri (Bupleurum chinense DC.), Radix Angelicae Sinensis (Angelica sinensis (Oliv.) Diels), Radix Paeoniae Alba (Paeonia lactiflora Pall.), Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala Koidz.), Poria (Poria cocos (Schw.) Wolf), Radix Glycyrrhizae (Glycyrrhiza uralensis Fisch.), Herba Menthae (Mentha haplocalyx Briq.), and Rhizoma Zingiberis Recens (Zingiber officinale Rosc.), has been widely used in the clinic for treating mental disorders. Behavior and biochemical analyses indicate XYS has obvious anti-depression activity. However, there is no report on the effects of XYS using a metabolomics approach. Depression is a prevalent complex psychiatric disorder and its pathophysiological mechanism is not yet well understood. This paper was designed to study metabonomic characters of the depression induced by chronic unpredictable mild stress (CUMS) and the therapeutic effects of XYS, classic traditional Chinese medicine (TCM) in treating the depression. A plasma metabonomics method based on gas chromatography/mass spectrometry (GC/MS) was developed. Principal component analysis (PCA) was utilized to classify and reveal the differences between the model group and control group. In turns, the concentration of these differences was analyzed with t-test to determine whether XYS was possible to influence the metabolic pattern induced by CUMS. The significant difference in metabolic profiling was observed from model group compared with drug-dose group by using the PCA, indicating the recovery effect of XYS on CUMS rats. Some significantly changed metabolites like glycine, glucose and hexadecanoic acid have been identified. These biochemical changes are related to the disturbance in amino acid metabolism, energy metabolism and glycometabolism, which are helpful to further understand the CUMS and the therapeutic mechanism of XYS. Metabonomic approach is helpful to further understanding the pathophysiology of depression and assisting in clinical diagnosis of depression and is also a valuable tool for studying the essence of Chinese medicine's syndrome theory and therapeutic effect mechanism of TCM." @default.
• W2134332397 created "2016-06-24" @default.
• W2134332397 creator A5002080787 @default.
• W2134332397 creator A5008795836 @default.
• W2134332397 creator A5033681865 @default.
• W2134332397 creator A5034365970 @default.
• W2134332397 creator A5044330053 @default.
• W2134332397 creator A5048516597 @default.
• W2134332397 creator A5051795250 @default.
• W2134332397 creator A5086796391 @default.
• W2134332397 creator A5087749907 @default.
• W2134332397 date "2011-09-01" @default.
• W2134332397 modified "2023-10-14" @default.
• W2134332397 title "Metabonomic study on chronic unpredictable mild stress and intervention effects of Xiaoyaosan in rats using gas chromatography coupled with mass spectrometry" @default.
• W2134332397 cites W1597273370 @default.
• W2134332397 cites W1797956629 @default.
• W2134332397 cites W1967225297 @default.
• W2134332397 cites W1969889522 @default.
• W2134332397 cites W1970421748 @default.
• W2134332397 cites W1972292960 @default.
• W2134332397 cites W1992631164 @default.
• W2134332397 cites W2004933560 @default.
• W2134332397 cites W2016345306 @default.
• W2134332397 cites W2021388555 @default.
• W2134332397 cites W2030826032 @default.
• W2134332397 cites W2033926759 @default.
• W2134332397 cites W2035335774 @default.
• W2134332397 cites W2037048890 @default.
• W2134332397 cites W2038875755 @default.
• W2134332397 cites W2043652950 @default.
• W2134332397 cites W2047260853 @default.
• W2134332397 cites W2050632824 @default.
• W2134332397 cites W2053052416 @default.
• W2134332397 cites W2053702145 @default.
• W2134332397 cites W2055466383 @default.
• W2134332397 cites W2064898130 @default.
• W2134332397 cites W2066775313 @default.
• W2134332397 cites W2068076567 @default.
• W2134332397 cites W2069370185 @default.
• W2134332397 cites W2069470844 @default.
• W2134332397 cites W2070612991 @default.
• W2134332397 cites W2071765053 @default.
• W2134332397 cites W2073636547 @default.
• W2134332397 cites W2085339275 @default.
• W2134332397 cites W2086110995 @default.
• W2134332397 cites W2087658529 @default.
• W2134332397 cites W2092581653 @default.
• W2134332397 cites W2098539376 @default.
• W2134332397 cites W2100640047 @default.
• W2134332397 cites W2130382164 @default.
• W2134332397 cites W2137350331 @default.
• W2134332397 cites W4238350088 @default.
• W2134332397 doi "https://doi.org/10.1016/j.jep.2011.06.024" @default.
• W2134332397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21718771" @default.
• W2134332397 hasPublicationYear "2011" @default.
• W2134332397 type Work @default.
• W2134332397 sameAs 2134332397 @default.
• W2134332397 citedByCount "72" @default.
• W2134332397 countsByYear W21343323972012 @default.
• W2134332397 countsByYear W21343323972013 @default.
• W2134332397 countsByYear W21343323972014 @default.
• W2134332397 countsByYear W21343323972015 @default.
• W2134332397 countsByYear W21343323972016 @default.
• W2134332397 countsByYear W21343323972017 @default.
• W2134332397 countsByYear W21343323972018 @default.
• W2134332397 countsByYear W21343323972019 @default.
• W2134332397 countsByYear W21343323972020 @default.
• W2134332397 countsByYear W21343323972021 @default.
• W2134332397 countsByYear W21343323972022 @default.
• W2134332397 countsByYear W21343323972023 @default.
• W2134332397 crossrefType "journal-article" @default.
• W2134332397 hasAuthorship W2134332397A5002080787 @default.
• W2134332397 hasAuthorship W2134332397A5008795836 @default.
• W2134332397 hasAuthorship W2134332397A5033681865 @default.
• W2134332397 hasAuthorship W2134332397A5034365970 @default.
• W2134332397 hasAuthorship W2134332397A5044330053 @default.
• W2134332397 hasAuthorship W2134332397A5048516597 @default.
• W2134332397 hasAuthorship W2134332397A5051795250 @default.
• W2134332397 hasAuthorship W2134332397A5086796391 @default.
• W2134332397 hasAuthorship W2134332397A5087749907 @default.
• W2134332397 hasConcept C142724271 @default.
• W2134332397 hasConcept C162356407 @default.
• W2134332397 hasConcept C185592680 @default.
• W2134332397 hasConcept C188947578 @default.
• W2134332397 hasConcept C204787440 @default.
• W2134332397 hasConcept C205345274 @default.
• W2134332397 hasConcept C21565614 @default.
• W2134332397 hasConcept C2778058069 @default.
• W2134332397 hasConcept C2778956427 @default.
• W2134332397 hasConcept C2779091547 @default.
• W2134332397 hasConcept C2779454681 @default.
• W2134332397 hasConcept C2779655422 @default.
• W2134332397 hasConcept C43617362 @default.
• W2134332397 hasConcept C556039675 @default.
• W2134332397 hasConcept C59822182 @default.
• W2134332397 hasConcept C71924100 @default.
• W2134332397 hasConcept C86803240 @default.
• W2134332397 hasConcept C98274493 @default.

• next