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- W2134332505 abstract "Patients with AIDS who become infected with Cryptococcus neoformans have a poor prognosis. We speculated that the presence of cryptococcal capsular polysaccharide may enhance HIV-1 infection. In an in-vitro study, the presence of cryptococcal polysaccharide significantly increased (p less than 0.05) production of p24 antigen after infection of H9 cells with HIV-1-infected H9 cells. We also found similar results when lymphocytes from an HIV-1-infected patient were co-cultured with mononuclear cells from an uninfected individual. Our findings suggest a new pathogenic role for the capsular polysaccharide--namely, the capacity to enhance HIV-1 infectivity." @default.
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- W2134332505 date "1992-01-01" @default.
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- W2134332505 title "Enhancement of HIV-1 infection by the capsular polysaccharide of Cryptococcus neoformans" @default.
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- W2134332505 doi "https://doi.org/10.1016/0140-6736(92)90142-p" @default.
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