FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134335220> ?p ?o ?g. }

• W2134335220 endingPage "1373" @default.
• W2134335220 startingPage "1365" @default.
• W2134335220 abstract "We investigated the chronic effects of doxorubicin (DXR) on morphological and functional changes in the rabbit mesenteric artery using an organ culture system. In arteries cultured with 0.3 μM DXR for 7 days, the contractions induced by noradrenaline, but not those induced by endothelin-1 or high K+, were strongly inhibited. This reaction was followed by a decrease in the induction of the α1A-adrenoceptor without any change in the mRNA level. Inhibition of noradrenaline-induced contractions by DXR was attenuated by superoxide dismutase, and α1A-adrenoceptor protein expression recovered. In the arteries cultured with 1 μM DXR for 7 days, contractions induced by endothelin-1 or high K+ and absolute force in the permeabilized muscles were also inhibited. Morphological examinations revealed the existence of concentrated nuclei and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling (TUNEL)-positive smooth muscle cells, and internucleosomal DNA fragmentation was also detected, indicating the induction of apoptosis. In the arteries cultured with 10 μM DXR for 7 days, nuclear swelling, karyolysis and random DNA fragmentation indicative of necrosis were observed, and muscle contractility was abolished. These results suggest that 0.3 μM DXR selectively down-regulates the α1A-adrenoceptor protein expression, resulting in a decrease in the noradrenaline-induced contraction. This down-regulation may be at least partly due to the production of a superoxide radical. DXR also caused a decrease in muscle contractility followed by apoptotic changes at 1 μM and necrotic changes at 10 μM. These changes might be responsible for the disturbance of the circulatory system that is often observed during the course of repetitive chemotherapy. British Journal of Pharmacology (2001) 132, 1365–1373; doi:10.1038/sj.bjp.0703959" @default.
• W2134335220 created "2016-06-24" @default.
• W2134335220 creator A5004620947 @default.
• W2134335220 creator A5006676797 @default.
• W2134335220 creator A5016429745 @default.
• W2134335220 creator A5023789798 @default.
• W2134335220 creator A5050233578 @default.
• W2134335220 creator A5088628108 @default.
• W2134335220 date "2001-04-01" @default.
• W2134335220 modified "2023-10-03" @default.
• W2134335220 title "Chronic vascular toxicity of doxorubicin in an organ-cultured artery" @default.
• W2134335220 cites W1529267387 @default.
• W2134335220 cites W1531780611 @default.
• W2134335220 cites W1605124616 @default.
• W2134335220 cites W1828224642 @default.
• W2134335220 cites W1964823618 @default.
• W2134335220 cites W1970676556 @default.
• W2134335220 cites W1978458525 @default.
• W2134335220 cites W1984390541 @default.
• W2134335220 cites W1993208793 @default.
• W2134335220 cites W1998402254 @default.
• W2134335220 cites W1999929858 @default.
• W2134335220 cites W2002788454 @default.
• W2134335220 cites W2005408885 @default.
• W2134335220 cites W2027455996 @default.
• W2134335220 cites W2031379138 @default.
• W2134335220 cites W2039149747 @default.
• W2134335220 cites W2053547821 @default.
• W2134335220 cites W2069321621 @default.
• W2134335220 cites W2072238317 @default.
• W2134335220 cites W2074683376 @default.
• W2134335220 cites W2106104578 @default.
• W2134335220 cites W2134785329 @default.
• W2134335220 cites W2162646039 @default.
• W2134335220 cites W2400214377 @default.
• W2134335220 cites W2400544374 @default.
• W2134335220 cites W2412944916 @default.
• W2134335220 cites W2414529923 @default.
• W2134335220 cites W2417282402 @default.
• W2134335220 cites W332202582 @default.
• W2134335220 doi "https://doi.org/10.1038/sj.bjp.0703959" @default.
• W2134335220 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1572694" @default.
• W2134335220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11264228" @default.
• W2134335220 hasPublicationYear "2001" @default.
• W2134335220 type Work @default.
• W2134335220 sameAs 2134335220 @default.
• W2134335220 citedByCount "55" @default.
• W2134335220 countsByYear W21343352202012 @default.
• W2134335220 countsByYear W21343352202013 @default.
• W2134335220 countsByYear W21343352202014 @default.
• W2134335220 countsByYear W21343352202016 @default.
• W2134335220 countsByYear W21343352202017 @default.
• W2134335220 countsByYear W21343352202018 @default.
• W2134335220 countsByYear W21343352202019 @default.
• W2134335220 countsByYear W21343352202020 @default.
• W2134335220 countsByYear W21343352202021 @default.
• W2134335220 countsByYear W21343352202022 @default.
• W2134335220 countsByYear W21343352202023 @default.
• W2134335220 crossrefType "journal-article" @default.
• W2134335220 hasAuthorship W2134335220A5004620947 @default.
• W2134335220 hasAuthorship W2134335220A5006676797 @default.
• W2134335220 hasAuthorship W2134335220A5016429745 @default.
• W2134335220 hasAuthorship W2134335220A5023789798 @default.
• W2134335220 hasAuthorship W2134335220A5050233578 @default.
• W2134335220 hasAuthorship W2134335220A5088628108 @default.
• W2134335220 hasBestOaLocation W21343352201 @default.
• W2134335220 hasConcept C126322002 @default.
• W2134335220 hasConcept C134018914 @default.
• W2134335220 hasConcept C154113507 @default.
• W2134335220 hasConcept C18903297 @default.
• W2134335220 hasConcept C190283241 @default.
• W2134335220 hasConcept C191015642 @default.
• W2134335220 hasConcept C196795494 @default.
• W2134335220 hasConcept C2775838275 @default.
• W2134335220 hasConcept C2776151105 @default.
• W2134335220 hasConcept C2776694085 @default.
• W2134335220 hasConcept C2776820930 @default.
• W2134335220 hasConcept C2779395532 @default.
• W2134335220 hasConcept C2780771799 @default.
• W2134335220 hasConcept C2781303535 @default.
• W2134335220 hasConcept C2992686903 @default.
• W2134335220 hasConcept C31573885 @default.
• W2134335220 hasConcept C39133596 @default.
• W2134335220 hasConcept C43759708 @default.
• W2134335220 hasConcept C55493867 @default.
• W2134335220 hasConcept C71924100 @default.
• W2134335220 hasConcept C86803240 @default.
• W2134335220 hasConceptScore W2134335220C126322002 @default.
• W2134335220 hasConceptScore W2134335220C134018914 @default.
• W2134335220 hasConceptScore W2134335220C154113507 @default.
• W2134335220 hasConceptScore W2134335220C18903297 @default.
• W2134335220 hasConceptScore W2134335220C190283241 @default.
• W2134335220 hasConceptScore W2134335220C191015642 @default.
• W2134335220 hasConceptScore W2134335220C196795494 @default.
• W2134335220 hasConceptScore W2134335220C2775838275 @default.
• W2134335220 hasConceptScore W2134335220C2776151105 @default.
• W2134335220 hasConceptScore W2134335220C2776694085 @default.
• W2134335220 hasConceptScore W2134335220C2776820930 @default.

• next