FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2134364025> ?p ?o ?g. }

• W2134364025 endingPage "291" @default.
• W2134364025 startingPage "259" @default.
• W2134364025 abstract "MHC class II molecules assemble in the endoplasmic reticulum in a chaperone-mediated fashion to form a nine-chain structure consisting of three alpha beta dimers associated with an invariant chain trimer. This complex is transported through the Golgi apparatus and into the endosomal system. The signal for endosomal targeting resides in the cytoplasmic tail of the invariant chain. Current evidence argues that the segregation of the class II-invariant chain complex from the constitutive pathway of membrane protein transport occurs in the trans-Golgi network. However, class II-invariant chain complexes that reach the cell surface are also rapidly internalized into endosomes. Within the endosomal system, probably in a late endosome/pre-lysosome, the invariant chain is degraded, releasing alpha beta dimers that bind peptides predominantly derived from endocytosed proteins. Evidence suggests that many of these peptides are actually generated in lysosomes. The precise mechanisms involved in forming class II-peptide complexes are unclear, although the existence of antigen-processing mutants argues that additional gene products, at least one of which is encoded in the MHC, are involved. After binding peptides, class II molecules are transported by an unknown route to the cell surface, where their primary function of presenting antigenic peptides to CD4+ T cells is carried out." @default.
• W2134364025 created "2016-06-24" @default.
• W2134364025 creator A5065397632 @default.
• W2134364025 date "1994-04-01" @default.
• W2134364025 modified "2023-10-16" @default.
• W2134364025 title "Assembly, Transport, and Function of MHC Class II Molecules" @default.
• W2134364025 cites W1485928230 @default.
• W2134364025 cites W1494319977 @default.
• W2134364025 cites W1511047189 @default.
• W2134364025 cites W1555196812 @default.
• W2134364025 cites W1574203672 @default.
• W2134364025 cites W1585391064 @default.
• W2134364025 cites W1594381485 @default.
• W2134364025 cites W1598543622 @default.
• W2134364025 cites W1643239212 @default.
• W2134364025 cites W1897038524 @default.
• W2134364025 cites W1955514812 @default.
• W2134364025 cites W1963622435 @default.
• W2134364025 cites W1964243757 @default.
• W2134364025 cites W1965774536 @default.
• W2134364025 cites W1967582433 @default.
• W2134364025 cites W1967891379 @default.
• W2134364025 cites W1978790143 @default.
• W2134364025 cites W1981143248 @default.
• W2134364025 cites W1985661337 @default.
• W2134364025 cites W198596500 @default.
• W2134364025 cites W1988885420 @default.
• W2134364025 cites W1990137584 @default.
• W2134364025 cites W1992438598 @default.
• W2134364025 cites W1995482121 @default.
• W2134364025 cites W1996161348 @default.
• W2134364025 cites W1998434423 @default.
• W2134364025 cites W2000734326 @default.
• W2134364025 cites W2004797406 @default.
• W2134364025 cites W2006392794 @default.
• W2134364025 cites W2012952808 @default.
• W2134364025 cites W2013944211 @default.
• W2134364025 cites W2031316091 @default.
• W2134364025 cites W2044063726 @default.
• W2134364025 cites W2044812120 @default.
• W2134364025 cites W2048172864 @default.
• W2134364025 cites W2050613857 @default.
• W2134364025 cites W2051055933 @default.
• W2134364025 cites W2052736790 @default.
• W2134364025 cites W2063841466 @default.
• W2134364025 cites W2066844508 @default.
• W2134364025 cites W2066873997 @default.
• W2134364025 cites W2067267037 @default.
• W2134364025 cites W2069634988 @default.
• W2134364025 cites W2082307299 @default.
• W2134364025 cites W2084389750 @default.
• W2134364025 cites W2085831528 @default.
• W2134364025 cites W2086210763 @default.
• W2134364025 cites W2090342749 @default.
• W2134364025 cites W2093288045 @default.
• W2134364025 cites W2101561136 @default.
• W2134364025 cites W2107857115 @default.
• W2134364025 cites W2108599583 @default.
• W2134364025 cites W2109044345 @default.
• W2134364025 cites W2111441225 @default.
• W2134364025 cites W2122291762 @default.
• W2134364025 cites W2125841464 @default.
• W2134364025 cites W2145835705 @default.
• W2134364025 cites W2147363432 @default.
• W2134364025 cites W2151646462 @default.
• W2134364025 cites W2156687630 @default.
• W2134364025 cites W2158614848 @default.
• W2134364025 cites W2170385301 @default.
• W2134364025 cites W309166525 @default.
• W2134364025 cites W625556339 @default.
• W2134364025 doi "https://doi.org/10.1146/annurev.iy.12.040194.001355" @default.
• W2134364025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8011283" @default.
• W2134364025 hasPublicationYear "1994" @default.
• W2134364025 type Work @default.
• W2134364025 sameAs 2134364025 @default.
• W2134364025 citedByCount "754" @default.
• W2134364025 countsByYear W21343640252012 @default.
• W2134364025 countsByYear W21343640252013 @default.
• W2134364025 countsByYear W21343640252014 @default.
• W2134364025 countsByYear W21343640252015 @default.
• W2134364025 countsByYear W21343640252016 @default.
• W2134364025 countsByYear W21343640252017 @default.
• W2134364025 countsByYear W21343640252018 @default.
• W2134364025 countsByYear W21343640252019 @default.
• W2134364025 countsByYear W21343640252020 @default.
• W2134364025 countsByYear W21343640252021 @default.
• W2134364025 countsByYear W21343640252022 @default.
• W2134364025 countsByYear W21343640252023 @default.
• W2134364025 crossrefType "journal-article" @default.
• W2134364025 hasAuthorship W2134364025A5065397632 @default.
• W2134364025 hasConcept C102747710 @default.
• W2134364025 hasConcept C108249834 @default.
• W2134364025 hasConcept C119062480 @default.
• W2134364025 hasConcept C119997001 @default.
• W2134364025 hasConcept C147483822 @default.
• W2134364025 hasConcept C158617107 @default.
• W2134364025 hasConcept C170627219 @default.
• W2134364025 hasConcept C181199279 @default.

• next