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• W2134367629 startingPage "6160" @default.
• W2134367629 abstract "ABSTRACT Posttranslational modifications of transcription factors provide alternate protein interaction platforms that lead to varied downstream effects. We have investigated how the acetylation of EKLF plays a role in its ability to alter the β-like globin locus chromatin structure and activate transcription of the adult β-globin gene. By establishing an EKLF-null erythroid line whose closed β-locus chromatin structure and silent β-globin gene status can be rescued by retroviral infection of EKLF, we demonstrate the importance of EKLF acetylation at lysine 288 in the recruitment of CBP to the locus, modification of histone H3, occupancy by EKLF, opening of the chromatin structure, and transcription of adult β-globin. We also find that EKLF helps to coordinate this process by the specific association of its zinc finger domain with the histone H3 amino terminus. Although EKLF interacts equally well with H3.1 and H3.3, we find that only H3.3 is enriched at the adult β-globin promoter. These data emphasize the critical nature of lysine acetylation in transcription factor activity and enable us to propose a model of how modified EKLF integrates coactivators, chromatin remodelers, and nucleosomal components to alter epigenetic chromatin structure and stimulate transcription." @default.
• W2134367629 created "2016-06-24" @default.
• W2134367629 creator A5002966230 @default.
• W2134367629 creator A5033435468 @default.
• W2134367629 creator A5064488370 @default.
• W2134367629 creator A5069754990 @default.
• W2134367629 date "2008-10-15" @default.
• W2134367629 modified "2023-10-01" @default.
• W2134367629 title "Acetylation of EKLF Is Essential for Epigenetic Modification and Transcriptional Activation of the β-Globin Locus" @default.
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• W2134367629 doi "https://doi.org/10.1128/mcb.00919-08" @default.
• W2134367629 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2577412" @default.
• W2134367629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18710946" @default.
• W2134367629 hasPublicationYear "2008" @default.
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